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toxicity with vancomycin therapeutic drug monitoring vancomycin-induced renal tubular cell apoptosis via sup‐
guided by area under the concentration-time curve against pression of apoptosis，mitochondrial dysfunction，and oxi‐
a trough 15-20 μg/mL concentration[J]. Int J Antimicrob dative stress[J]. Phytother Res，2019，33（8）：2056-2063.
Agents，2020，56（4）：106109. [12] HOLFORD N，O’HANLON C J，ALLEGAERT K，et al.
[ 2 ] 何娜，苏珊，翟所迪，等. 《中国万古霉素治疗药物监测指 A physiological approach to renal clearance：from prema‐
南（2020 更新版）》解读[J]. 临床药物治疗杂志，2021，19 ture neonates to adults[J]. Br J Clin Pharmacol，2024，90
（1）：12-16. （4）：1066-1080.
[ 3 ] TSUTSUURA M，MORIYAMA H，KOJIMA N，et al. The [13] MURPHY M，GIRDWOOD S T，SCHEETZ M H. Cli-
monitoring of vancomycin：a systematic review and meta- nical guideline highlights for the hospitalist：therapeutic
analyses of area under the concentration-time curve- monitoring of vancomycin[J]. J Hosp Med，2020，15（12）：
guided dosing and trough-guided dosing[J]. BMC Infect 740-742.
Dis，2021，21（1）：153. [14] 白一兵，赵玉，马悦，等. 中性粒细胞缺乏患者万古霉素
[ 4 ] RYBAK M J，LE J，LODISE T P，et al. Therapeutic moni‐ 血药浓度影响因素分析[J]. 医药导报，2022，41（10）：
toring of vancomycin for serious methicillin-resistant 1523-1527.
Staphylococcus aureus infections：a revised consensus [15] WANG H，TANG C，DANG Z H，et al. Clinicopatholo-
guideline and review by the American Society of Health- gical characteristics of high-altitude polycythemia-related
System Pharmacists，the Infectious Diseases Society of kidney disease in Tibetan inhabitants[J]. Kidney Int，2022，
America，the Pediatric Infectious Diseases Society，and 102（1）：196-206.
the Society of Infectious Diseases Pharmacists[J]. Am J [16] PU L L，XU H B，WANG Z R，et al. Intermittent high alti‐
Health Syst Pharm，2020，77（11）：835-864. tude hypoxia induced liver and kidney injury leading to
[ 5 ] BAIGENT C，EMBERSON J，HAYNES R，et al. Impact hyperuricemia[J]. Arch Biochem Biophys，2024，758：
of diabetes on the effects of sodium glucose co- 110078.
transporter-2 inhibitors on kidney outcomes：collaborative [17] VAN BOMMEL E J M，RUITER D，MUSKIET M H A，
meta-analysis of large placebo-controlled trials[J]. Lancet， et al. Insulin sensitivity and renal hemodynamic function
2022，400（10365）：1788-1801. in metformin-treated adults with type 2 diabetes and pre‐
[ 6 ] WANG Q，LIU G Q，DUAN Y B，et al. Exploring cyto‐ served renal function[J]. Diabetes Care，2020，43（1）：
chrome P450 under hypoxia：potential pharmacological 228-234.
significance in drug metabolism and protection against [18] CHU Y G，ZHOU Y，LU S H，et al. Pathogenesis of
high-altitude diseases[J]. Drug Metab Dispos，2025，53 higher blood pressure and worse renal function in salt-
（2）：100026. sensitive hypertension[J]. Kidney Blood Press Res，2021，
[ 7 ] LIU J H，XIN Z B，HUANG Y Z，et al. Climate suitability 46（2）：236-244.
assessment on the Qinghai-Tibet Plateau[J]. Sci Total En‐ [19] DUAN Y B，BAI X，YANG J X，et al. Exposure to high-
viron，2022，816：151653. altitude environment is associated with drug transporters
[ 8 ] WANG S Y，GAO J，ZHAO J H. Effects of high altitude change：microRNA-873-5p-mediated alteration of func‐
on renal physiology and kidney diseases[J]. Front Physiol， tion and expression levels of drug transporters under hy‐
2022，13：969456. poxia[J]. Drug Metab Dispos，2022，50（2）：174-186.
[ 9 ] SU X Y，MATTHEWS T，HILDRETH M，et al. Activa‐ [20] BAI X，YANG J X，LIU G Q，et al. Regulation of
tion of sympathetic nervous system contributes to erthro‐ CYP450 and drug transporter mediated by gut microbiota
protein gene upregulation by hypobaric hypoxia[J]. under high-altitude hypoxia[J]. Front Pharmacol，2022，
FASEB J，2022，36（S1）：fasebj.2022.36.S1.R2781. 13：977370.
[10] QIU F F，SUN Y M，LI W B，et al. A review on drug- [21] LIU D，YU Q，LI Z B，et al. UGT1A1 dysfunction in‐
metabolizing enzymes，transporters，and gut microbiota on creases liver burden and aggravates hepatocyte damage
pharmacokinetics in high-altitude environment[J/OL]. caused by long-term bilirubin metabolism disorder[J]. Bio‐
Curr Drug Metab，2025[2025-11-15]. http：pubmed. nci. chem Pharmacol，2021，190：114592.
nlm.nih.gov/39931992/. （收稿日期：2025-08-18 修回日期：2025-12-11）
[11] QU S Q，DAI C C，GUO H，et al. Rutin attenuates （编辑：张元媛）

中国药房 2026年第37卷第2期 China Pharmacy 2026 Vol. 37 No. 2 · 203 ·