Page 117 - 《中国药房》2026年2期
P. 117

The  Cochrane  Collaboration’s  tool  for  assessing  risk  of   triple-negative  breast  cancer(TNBC)[J].  J  Clin  Oncol,
              bias in randomised trials[J]. BMJ,2011,343:d5928.   2021,39(Suppl. 15):506.
          [ 9 ]  SCHMID  P,CORTES  J,PUSZTAI  L,et  al.  Pembroli‐  [17]  GIANNI L,PIENKOWSKI T,IM Y H,et al. Efficacy and
              zumab for early triple-negative breast cancer[J]. N Engl J   safety  of  neoadjuvant  pertuzumab  and  trastuzumab  in
              Med,2020,382(9):810-821.                            women  with  locally  advanced,inflammatory,or  early
          [10]  CHEN L,LI H,ZHANG H,et al. Camrelizumab vs pla‐   HER2-positive breast cancer(NeoSphere):a randomised
              cebo  in  combination  with  chemotherapy  as  neoadjuvant   multicentre,open-label,phase  2  trial[J].  Lancet  Oncol,
              treatment in patients with early or locally advanced triple-  2012,13(1):25-32.
              negative breast cancer:the CamRelief randomized clinical   [18]  CORTAZAR  P,ZHANG  L  J,UNTCH  M,et  al.  Patho-
              trial[J]. JAMA,2025,333(8):673-681.                 logical  complete  response  and  long-term  clinical  benefit
          [11]  MITTENDORF  E A,ASSAF  Z  J,HARBECK  N,et  al.    in breast cancer:the CTNeoBC pooled analysis[J]. Lancet,
              Peri-operative  atezolizumab  in  early-stage  triple-negative   2014,384(9938):164-172.
              breast cancer:final results and ctDNA analyses from the   [19]  RIZZO  A,CUSMAI  A,MASSAFRA  R,et  al.  Patho-
              randomized  phase  3  IMpassion031  trial[J].  Nat  Med,  logical complete response to neoadjuvant chemoimmuno‐
                                                                  therapy for early triple-negative breast cancer:an updated
              2025,31(7):2397-2404.
          [12]  MITTENDORF E A,ZHANG H,BARRIOS C H,et al.         meta-analysis[J]. Cells,2022,11(12):1857.
                                                             [20]  VANHERSECKE  L,BRUNET  M,GUÉGAN  J  P,et  al.
              Neoadjuvant atezolizumab in combination with sequential
                                                                  Mature  tertiary  lymphoid  structures  predict  immune
              nab-paclitaxel and anthracycline-based chemotherapy ver‐
                                                                  checkpoint  inhibitor  efficacy  in  solid  tumors  indepen‐
              sus placebo and chemotherapy in patients with early-stage
                                                                  dently of PD-L1 expression[J]. Nat Cancer,2021,2(8):
              triple-negative  breast  cancer(IMpassion031):a  ran‐
                                                                  794-802.
              domised,double-blind,phase 3 trial[J]. Lancet,2020,396
                                                             [21]  LI  L Y,ZHANG  F,LIU  Z Y,et  al.  Immunotherapy  for
              (10257):1090-1100.
                                                                  triple-negative  breast  cancer:combination  strategies  to
          [13]  NANDA R,LIU M C,YAU C,et al. Effect of pembroli‐
                                                                  improve outcome[J]. Cancers,2023,15(1):321.
              zumab plus neoadjuvant chemotherapy on pathologic com‐
                                                             [22]  HE Q,PENG Y C,SUN J,et al. Platinum-based chemo‐
              plete  response  in  women  with  early-stage  breast  cancer:
                                                                  therapy and immunotherapy in early triple-negative breast
              an analysis of the ongoing phase 2 adaptively randomized
                                                                  cancer:a meta-analysis and indirect treatment comparison
              I-SPY2 trial[J]. JAMA Oncol,2020,6(5):676-684.
                                                                  [J]. Front Oncol,2021,11:693542.
          [14]  GEYER  C,TANG  G,NEKLJUDOVA V,et  al. Abstract
                                                             [23]  YANG Y L,LI H F,YANG W,et al. Improving efficacy
              GS3-05:NSABP  B-59/GBG-96-GeparDouze:a  rando-
                                                                  of  TNBC  immunotherapy:based  on  analysis  and  sub-
              mized double-blind phase Ⅲ clinical trial of neoadjuvant
                                                                  typing  of  immune  microenvironment[J].  Front  Immunol,
              chemotherapy  with  atezolizumab  or  placebo  followed  by
                                                                  2024,15:1441667.
              adjuvant atezolizumab or placebo in patients with stage Ⅱ   [24]  HOLDER A M,DEDEILIA A,SIERRA-DAVIDSON K,
              and Ⅲ triple-negative breast cancer[J]. Clin Cancer Res,
                                                                  et  al.  Defining  clinically  useful  biomarkers  of  immune
              2025,31(Suppl. 12):GS3-5-GS3-05.
                                                                  checkpoint inhibitors in solid tumours[J]. Nat Rev Cancer,
          [15]  LOIBL  S,UNTCH  M,BURCHARDI  N,et  al.  A  ran‐   2024,24(7):498-512.
              domised phase Ⅱ study investigating durvalumab in addi‐  [25]  HUOBER J,VAN MACKELENBERGH M,SCHNEEWEISS
              tion to an anthracycline taxane-based neoadjuvant therapy   A,et al. Identifying breast cancer patients at risk of relapse
              in  early  triple-negative  breast  cancer:clinical  results  and   despite  pathological  complete  response  after  neoadjuvant
              biomarker analysis of GeparNuevo study[J]. Ann Oncol,  therapy[J]. NPJ Breast Cancer,2023,9(1):23.
              2019,30(8):1279-1288.                          [26]  MIAO K,ZHANG L. Pathogenesis,pathological charac‐
          [16]  LOIBL S,SCHNEEWEISS A,HUOBER J B,et al. Dur‐      teristics  and  individualized  therapy  for  immune-related
              valumab  improves  long-term  outcome  in  TNBC:results   adverse effects[J]. Chin Med J Pulm Crit Care Med,2023,
              from  the  phase  Ⅱ  randomized  GeparNuevo  study  inves-  1(4):215-222.
              tigating neoadjuvant durvalumab in addition to an anthra‐     (收稿日期:2025-09-08  修回日期:2026-01-05)
              cycline/taxane  based  neoadjuvant  chemotherapy  in  early                         (编辑:陈   宏)







          中国药房  2026年第37卷第2期                                                 China Pharmacy  2026 Vol. 37  No. 2    · 243 ·
   112   113   114   115   116   117   118   119   120   121   122