Page 126 - 《中国药房》2025年9期
P. 126

A. Current therapy of the patients with MDS:walking to‐  world  experience  with  luspatercept  and  predictors  of  re‐
               wards personalized therapy[J]. J Clin Med,2021,10(10):  sponse  in  myelodysplastic  syndromes  with  ring  sidero‐
               2107.                                               blasts[J]. Am J Hematol,2022,97(6):E210-E214.
          [ 8 ]  HATZIMICHAEL E,TIMOTHEATOU D,KOUMPIS E,      [18]  LANINO  L,RESTUCCIA  F,PEREGO  A,et  al.  Real-
               et al. Luspatercept:a new tool for the treatment of anemia   world  efficacy  and  safety  of  luspatercept  and  predictive
               related to β-thalassemia,myelodysplastic syndromes and   factors of response in patients with lower risk myelodys‐
               primary myelofibrosis[J]. Diseases,2022,10(4):85.   plastic syndromes with ring sideroblasts[J]. Am J Hema‐
          [ 9 ]  SCHMIERER B,HILL C S. TGF-β-SMAD signal trans‐    tol,2023,98(8):E204-E208.
               duction:molecular specificity and functional flexibility[J].   [19]  KOONS  M,SIGNORELLI  J  R,BELL  C,et  al.  Real-
               Nat Rev Mol Cell Biol,2007,8(12):970-982.           world  practices  of  luspatercept  at  an  academic  medical
          [10]  FENAUX  P,HAASE  D,SANTINI  V,et  al.  Myelodys‐   center[J]. J Oncol Pharm Pract,2024,30(7):1173-1180.
               plastic syndromes:ESMO clinical practice guidelines for   [20]  GONG  Y,HE  G.  Topic:As08-treatment/AS08i-
               diagnosis,treatment and follow-up [J]. Ann Oncol,2021,  observational studies:real world data confirms activity of
               32(2):142-156.                                      luspatercept  in  higher  risk  and  hypomethylating  agents-
          [11]  LOCATELLI F,THOMPSON A A,KWIATKOWSKI J L,          failed  patients  with  myelodysplastic  syndromes[J].  Leuk
               et al. Betibeglogene autotemcel gene therapy for non-β /β    Res,2023,128:107275.
                                                         0
                                                       0
               genotype β-thalassemia[J]. N Engl J Med,2022,386(5):  [21]  MUKHERJEE S,BROWN-BICKERSTAFF C,MCBRIDE
               415-427.                                            A,et al. Real-world outcomes of patients with lower-risk
          [12]  HIGGINS  J  P  T,THOMPSON  S  G,DEEKS  J  J,et  al.   myelodysplastic  syndromes (LR-MDS)  treated  with
               Measuring inconsistency in meta-analyses[J]. BMJ,2003,  luspatercept:an evaluation of US clinical practice utiliza‐
               327(7414):557-560.                                  tion  and  treatment  patterns[J].  Blood,2022,140(Suppl.
          [13]  PLATZBECKER  U,GERMING  U,GÖTZE  K  S,et  al.      1):944-946.
               Luspatercept for the treatment of anaemia in patients with   [22]  KOMROKJI R S,AL ALI N,BALL S,et al. Luspatercept
               lower-risk  myelodysplastic  syndromes (PACE-MDS):a   for  treatment  of  lower  risk  myelodysplastic  syndromes:
               multicentre,open-label  phase  2  dose-finding  study  with   real world data replicates medalist study results and con‐
               long-term  extension  study[J].  Lancet  Oncol,2017,18  firms  activity  among  hypomethylating  agents  and
              (10):1338-1347.                                      lenalidomide-treated patients[J]. Blood,2022,140(Suppl.
          [14]  FENAUX  P,PLATZBECKER  U,MUFTI  G  J,et  al.       1):4039-4041.
               Luspatercept  in  patients  with  lower-risk  myelodysplastic   [23]  KOMROKJI R S,AGUIRRE L E,AL ALI N H,et al. Ac‐
               syndromes[J]. N Engl J Med,2020,382(2):140-151.     tivity of luspatercept and ESAs combination for treatment
          [15]  PLATZBECKER U,DELLA PORTA M G,SANTINI V,           of  anemia  in  lower-risk  myelodysplastic  syndromes[J].
               et  al.  Efficacy  and  safety  of  luspatercept  versus  epoetin   Blood Adv,2023,7(14):3677-3679.
               alfa in erythropoiesis-stimulating agent-naive,transfusion-  [24]  MALCOVATI L,STEVENSON K,PAPAEMMANUIL E,
               dependent,lower-risk  myelodysplastic  syndromes    et al. SF3B1-mutant MDS as a distinct disease subtype:a
              (COMMANDS):interim  analysis  of  a  phase  3,open-  proposal  from  the  International  Working  Group  for  the
               label,randomised  controlled  trial[J].  Lancet,2023,402  Prognosis of MDS[J]. Blood,2020,136(2):157-170.
              (10399):373-385.                                [25]  GARZA A D L,CAMERON R C,GUPTA V,et al. The
          [16]  ZHANG Z X,HU Q L,TANG X D,et al. Treatment of      splicing  factor  Sf3b1  regulates  erythroid  maturation  and
               refractory  or  relapsed  myelodysplastic  neoplasms  with     proliferation  via  TGF- β  signaling  in  zebrafish[J].  Blood
               luspatercept:a multicenter Chinese study[J]. Ann Hematol,  Adv,2019,3(14):2093-2104.
               2023,102(11):3039-3047.                                      (收稿日期:2024-10-29  修回日期:2025-02-20)
          [17]  FARRUKH  F,CHETRAM  D,AL-KALI A,et  al.  Real-                                    (编辑:刘明伟)










          · 1140 ·    China Pharmacy  2025 Vol. 36  No. 9                              中国药房  2025年第36卷第9期
   121   122   123   124   125   126   127   128   129   130   131