Page 84 - 《中国药房》2025年7期
P. 84

PI3K激活剂740 Y-P,结果显示,Met对PI3K/AKT/PDGF                    作用机制[J]. 中西医结合心脑血管病杂志,2024,22(9):
          信号通路的抑制作用可被740 Y-P逆转。                                    1604-1609.
              综上所述,Met可改善NASH大鼠肝损伤,减轻炎症                       [13]  彭晓娟,钟绿,吴楚添,等. 青钱柳多糖和青钱柳黄酮对
          反应和肝纤维化,其作用机制可能与抑制 PI3K/AKT/                             非酒精性脂肪性肝病合并 2 型糖尿病模型大鼠血液代
          PDGF信号通路活性有关。                                            谢指标及肝脏病变的影响[J]. 中国病理生理杂志,2021,
                                                                   37(10):1838-1847.
          参考文献
                                                              [14]  BHARATH  L  P,NIKOLAJCZYK  B  S.  The  intersection
          [ 1 ]  LIN Z B,YANG P J,HU Y F,et al. Ring finger protein 13
                                                                   of  metformin  and  inflammation[J].  Am  J  Physiol  Cell
               protects  against  nonalcoholic  steatohepatitis  by  targeting
                                                                   Physiol,2021,320(5):C873-C879.
               STING-relayed  signaling  pathways[J].  Nat  Commun,
                                                              [15]  RUAN G Y,WU F Q,SHI D B,et al. Metformin:update
               2023,14(1):6635.
                                                                   on mechanisms of action on liver diseases[J]. Front Nutr,
          [ 2 ]  XU X H,POULSEN K L,WU L J,et al. Targeted thera‐
                                                                   2023,10:1327814.
               peutics  and  novel  signaling  pathways  in  non-alcohol-
                                                              [16]  GUO  M  D,ZHU  C  H,FU  R  Z,et  al.  Ginsenoside  Rk3
               associated  fatty  liver/steatohepatitis (NAFL/NASH)[J].
                                                                   regulates nonalcoholic steatohepatitis by modulation of in‐
               Signal Transduct Target Ther,2022,7(1):287.
                                                                   testinal  flora  and  the  PI3K/AKT  signaling  pathway  in
          [ 3 ]  FORETZ  M,GUIGAS  B,VIOLLET  B.  Metformin:up‐
                                                                   C57BL/6  mice[J].  J  Agric  Food  Chem,2023,71(24):
               date  on  mechanisms  of  action  and  repurposing  potential
                                                                   9370-9380.
               [J]. Nat Rev Endocrinol,2023,19(8):460-476.
                                                              [17]  SONG  J,QIU  H  R,DU  P,et  al.  Polyphenols  extracted
          [ 4 ]  李瑞芳,卜淑蕊. 二甲双胍对高脂饮食诱导的非酒精性
                                                                   from Shanxi-aged vinegar exert hypolipidemic effects on
               脂肪性肝病大鼠肠道菌群的影响[J]. 中华消化杂志,
                                                                   OA-induced HepG2 cells via the PPARα-LXRα-ABCA1
               2020,40(12):861-867.
                                                                   pathway[J]. J Food Biochem,2022,46(2):e14029.
          [ 5 ]  SONG H,ZHANG X J,ZHAI R Q,et al. Metformin at‐
                                                              [18]  郭威,李三强,宋晓改,等 . L-谷氨酰胺对急性酒精肝损
               tenuated  sepsis-associated  liver  injury  and  inflammatory
                                                                   伤小鼠的保护作用机制研究[J]. 中国临床药理学杂志,
               response  in  aged  mice[J].  Bioengineered,2022,13(2):  2020,36(13):1812-1814.
               4598-4609.
                                                              [19]  DUAN Y  M,PAN  X  F,LUO  J Y,et  al. Association  of
          [ 6 ]  吕春卉,李大炜,王小洁,等. 二甲双胍联合辛伐他汀治
                                                                   inflammatory  cytokines  with  non-alcoholic  fatty  liver
               疗非酒精性脂肪性肝病合并 2 型糖尿病患者疗效研究                           disease[J]. Front Immunol,2022,13:880298.
               [J]. 实用肝脏病杂志,2022,25(1):50-53.                 [20]  FENG Y Y,WANG Z J,PANG H. Role of metformin in
          [ 7 ]  YU Y J,ZHOU S Z,WANG Y,et al. Leonurine alleviates   inflammation[J]. Mol Biol Rep,2023,50(1):789-798.
               acetaminophen-induced  acute  liver  injury  by  regulating   [21]  LI J D,WANG T Q,LIU P P,et al. Hesperetin ameliorates
               the PI3K/AKT signaling pathway in mice[J]. Int Immuno‐  hepatic  oxidative  stress  and  inflammation  via  the  PI3K/
               pharmacol,2023,120:110375.                          AKT-Nrf2-ARE  pathway  in  oleic  acid-induced  HepG2
          [ 8 ]  XU X Y,GENG Y,XU H X,et al. Antrodia camphorata-  cells and a rat model of high-fat diet-induced NAFLD[J].
               derived antrodin C inhibits liver fibrosis by blocking TGF-  Food Funct,2021,12(9):3898-3918.
               beta and PDGF signaling pathways[J]. Front Mol Biosci,  [22]  WALLACE S J,TACKE F,SCHWABE R F,et al. Under‐
               2022,9:835508.                                      standing  the  cellular  interactome  of  non-alcoholic  fatty
          [ 9 ]  YE Q,LIU Y,ZHANG G J,et al. Deficiency of gluconeo‐  liver disease[J]. JHEP Rep,2022,4(8):100524.
               genic  enzyme  PCK1  promotes  metabolic-associated  fatty   [23]  WANG Y F,WANG P Y,YU Y B,et al. Hepatocyte Nin‐
               liver disease through PI3K/AKT/PDGF axis activation in   jurin2 promotes hepatic stellate cell activation and liver fi‐
               male mice[J]. Nat Commun,2023,14(1):1402.           brosis  through  the  IGF1R/EGR1/PDGF-BB  signaling
          [10]  EMAN E,HEMAT E,HANAA H,et al. Effects of berberine   pathway[J]. Metabolism,2023,140:155380.
               on high-fat/high-sucrose-induced nonalcoholic steatohepa‐  [24]  WANG S,CHEN B H,DU R L,et al. An herbal formula‐
               titis in experimental rats[J]. Tanta Med J,2019,47(2):80.  tion “Shugan xiaozhi decoction” ameliorates methionine/
          [11]  岳亚光,檀薇薇,王文川,等 . 二甲双胍经 Nrf2-Gpx4 通                  choline  deficiency-induced  nonalcoholic  steatohepatitis
               路抑制铁死亡并减轻非酒精性脂肪性肝病大鼠的肝损                             through  regulating  inflammation  and  apoptosis-related
               伤[J]. 中国病理生理杂志,2021,37(10):1848-1857.               pathways[J]. J Ethnopharmacol,2024,329:118127.
          [12]  李彩艳,王东枝,张冰,等 . 基于瘦素介导的 PI3K/AKT                             (收稿日期:2024-10-12  修回日期:2025-02-08)
               通路探讨二甲双胍对脑卒中相关性肺炎大鼠肺损伤的                                                            (编辑:唐晓莲)





          · 842 ·    China Pharmacy  2025 Vol. 36  No. 7                               中国药房  2025年第36卷第7期
   79   80   81   82   83   84   85   86   87   88   89