Page 63 - 《中国药房》2024年2期

activated PPARδ inhibits angiotensin Ⅱ-stimulated hyper‐ [14] 孙鹤宁，鲁美丽，田小雪，等. Calpain-1通过诱导内质网
trophy of vascular smooth muscle cells by targeting ROS 应激加速肺动脉高压的内皮细胞凋亡[J]. 中国药理学通
[J]. PLoS One，2019，14（1）：e0210482. 报，2023，39（4）：723-730.
[ 6 ] 陈昌贵，易春峰，王栋，等. PPARδ的激活通过抑制糖酵 SUN H N，LU M L，TIAN X X，et al. Calpain-1 accele-
解减轻 PDGF-BB 诱导的肺动脉平滑肌细胞表型转化 rates endothelial cell apoptosis in pulmonary hypertension
[J]. 中国病理生理杂志，2023，39（6）：988-995. by inducing endoplasmic reticulum stress[J]. Chin Phar‐
CHEN C G，YI C F，WANG D，et al. Activation of PPARδ macol Bull，2023，39（4）：723-730.
suppresses phenotypic switching of PDGF-BB-induced [15] LIU F，FANG S H，LIU X X，et al. Omentin-1 protects
pulmonary artery smooth muscle cells via inhibition of against high glucose-induced endothelial dysfunction via
glycolysis[J]. Chin J Pathophysiol，2023，39（6）：988-995. the AMPK/PPARδ signaling pathway[J]. Biochem Phar‐
[ 7 ] YAMADA T，EGASHIRA N，BANDO A，et al. Activation macol，2020，174：113830.
of p38 MAPK by oxidative stress underlying epirubicin- [16] TIAN Q Q，LEUNG F P，CHEN F M，et al. Butyrate pro‐
induced vascular endothelial cell injury[J]. Free Radic tects endothelial function through PPARδ/miR-181b
Biol Med，2012，52（8）：1285-1293. signaling[J]. Pharmacol Res，2021，169：105681.
[ 8 ] PASCALE C L，MARTINEZ A N，CARR C，et al. Treat‐ [17] CHEN Y C，YUAN T Y，ZHANG H F，et al. Activation of
ment with dimethyl fumarate reduces the formation and Nrf2 attenuates pulmonary vascular remodeling via inhibiting
rupture of intracranial aneurysms：role of Nrf2 activation endothelial-to-mesenchymal transition：an insight from a
[J]. J Cereb Blood Flow Metab，2020，40（5）：1077-1089. plant polyphenol[J]. Int J Biol Sci，2017，13（8）：1067-
[ 9 ] JIN D H，LIN L H，XIE Y X，et al. NRF2-suppressed 1081.
vascular calcification by regulating the antioxidant pathway [18] ARCHER S L，MARSBOOM G，KIM G H，et al. Epige-
in chronic kidney disease[J]. FASEB J，2022，36（1）： netic attenuation of mitochondrial superoxide dismutase 2
e22098. in pulmonary arterial hypertension：a basis for excessive
[10] JIANG Y，LIU H Y，YU H，et al. Circular RNA Calm4 cell proliferation and a new therapeutic target[J]. Circula‐
regulates hypoxia-induced pulmonary arterial smooth tion，2010，121（24）：2661-2671.
muscle cells pyroptosis via the circ-Calm4/miR-124-3p/ [19] 葛亮，向悦华，谭旎. Nrf2激活剂缓解低氧性肺动脉高压
PDCD6 axis[J]. Arterioscler Thromb Vasc Biol，2021，41 大鼠肺血管重构[J]. 基础医学与临床，2021，41（10）：
（5）：1675-1693. 1446-1450.
[11] WANG R，PAN J J，HAN J Z，et al. Melatonin attenuates GE L，XIANG Y H，TAN N. Nrf2 activator relieves pul‐
dasatinib-aggravated hypoxic pulmonary hypertension via monary vascular remodeling in rats with hypoxic pulmo‐
inhibiting pulmonary vascular remodeling[J]. Front Car‐ nary arterial hypertension[J]. Basic Clin Med，2021，41
diovasc Med，2022，9：790921. （10）：1446-1450.
[12] HAN J K，LEE H S，YANG H M，et al. Peroxisome [20] JIMENEZ R，TORAL M，GÓMEZ-GUZMÁN M，et al.
proliferator-activated receptor-delta agonist enhances The role of Nrf2 signaling in PPARβ/δ-mediated vascular
vasculogenesis by regulating endothelial progenitor cells protection against hyperglycemia-induced oxidative stress
through genomic and nongenomic activations of the pho- [J]. Oxid Med Cell Longev，2018，2018：5852706.
sphatidylinositol 3-kinase/Akt pathway[J]. Circulation， [21] D'USCIO L V，HE T R，SANTHANAM A V，et al.
2008，118（10）：1021-1033. Mechanisms of vascular dysfunction in mice with endo-
[13] AIMAIER S，YANG T，FANG L，et al. Protective effects thelium-specific deletion of the PPAR- δ gene[J]. Am J
of the Terminalia bellirica tannin-induced Nrf2/HO-1 Physiol Heart Circ Physiol，2014，306（7）：H1001-H1010.
signaling pathway in rats with high-altitude pulmonary （收稿日期：2023-06-06 修回日期：2023-11-20）
hypertension[J]. BMC Complement Med Ther，2023，23 （编辑：曾海蓉）
（1）：150.

中国药房 2024年第35卷第2期 China Pharmacy 2024 Vol. 35 No. 2 · 185 ·