Page 103 - 《中国药房》2022年19期
P. 103
diovascular events[J]. N Engl J Med,2015,372(16): submitted to FAERS[J]. Clin Drug Investig,2019,39(3):
1489-1499. 319-330.
[ 9 ] LIPINSKI M J,BENEDETTO U,ESCARCEGA R O, [18] SIAFIS S,PAPAZISIS G. Detecting a potential safety
et al. The impact of proprotein convertase subtilisin-kexin signal of antidepressants and type 2 diabetes:a
type 9 serine protease inhibitors on lipid levels and out‐ pharmacovigilance-pharmacodynamic study[J]. Br J Clin
comes in patients with primary hypercholesterolaemia:a Pharmacol,2018,84(10):2405-2414.
network meta-analysis[J]. Eur Heart J,2016,37(6): [19] BJÖRKHEM I,MEANEY S. Brain cholesterol:long
536-545. secret life behind a barrier[J]. Arterioscler Thromb Vasc
[10] KHAN A R,BAVISHI C,RIAZ H,et al. Increased risk of Biol,2004,24(5):806-815.
adverse neurocognitive outcomes with proprotein conver‐ [20] JOSEPH J A,DENISOVA N,VILLALOBOS-MOLINA R,
tase subtilisin-kexin type 9 inhibitors[J]. Circ Cardiovasc et al. Oxidative stress and age-related neuronal deficits[J].
Qual Outcomes,2017,10(1):e003153. Mol Chem Neuropathol,1996,28(1-3):35-40.
[11] BAJAJ N S,PATEL N,KALRA R,et al. Neurological [21] O’CONNELL E M,LOHOFF F W. Proprotein convertase
effects of proprotein convertase subtilisin/kexin type 9 subtilisin/kexin type 9(PCSK9)in the brain and rele-
inhibitors:direct comparisons[J]. Eur Heart J Qual Care vance for neuropsychiatric disorders[J]. Front Neurosci,
Clin Outcomes,2018,4(2):132-141. 2020,14:609.
[12] HARVEY P D,SABBAGH M N,HARRISON J E,et al. [22] MANNARINO M R,SAHEBKAR A,BIANCONI V,et al.
No evidence of neurocognitive adverse events associated PCSK9 and neurocognitive function:should it be still an
with alirocumab treatment in 3 340 patients from 14 rando- issue after FOURIER and EBBINGHAUS results? [J]. J
mized Phase 2 and 3 controlled trials:a meta-analysis of Clin Lipidol,2018,12(5):1123-1132.
individual patient data[J]. Eur Heart J,2018,39(5): [23] ADORNI M P,RUSCICA M,FERRI N,et al. Proprotein
374-381. convertase subtilisin/kexin type 9,brain cholesterol
[13] HIRSH RACCAH B,YANOVSKY A,TREVES N,et al. homeostasis and potential implication for Alzheimer’s
Proprotein Convertase Subtilisin/Kexin Type 9(PCSK9) disease[J]. Front Aging Neurosci,2019,11:120.
inhibitors and the risk for neurocognitive adverse events:a [24] REITZ C. Dyslipidemia and dementia:current epidemiology,
systematic review,meta-analysis and meta-regression[J]. genetic evidence,and mechanisms behind the associations
Int J Cardiol,2021,335:7-14. [J].J Alzheimers Dis,2012,30,Suppl 2(2):S127-S145.
[14] KIM H S,LEE S,KIM J H. Real-world evidence versus [25] GÜRGÖZE M T,MULLER-HANSMA A H G,SCHREUDER
randomized controlled trial:clinical research based on M M,et al. Adverse events associated with PCSK9 inhibi‐
electronic medical records[J]. J Korean Med Sci,2018,33 tors:a real-world experience[J]. Clin Pharmacol Ther,
(34):e213. 2019,105(2):496-504.
[15] ROBIN X,TURCK N,HAINARD A,et al. pROC:an [26] MEFFORD M T,ROSENSON R S,CUSHMAN M,et al.
open-source package for R and S+ to analyze and PCSK9 variants,low-density lipoprotein cholesterol,and
compare ROC curves[J]. BMC Bioinformatics,2011, neurocognitive impairment:reasons for geographic and
12:77. racial differences in stroke study(REGARDS)[J]. Circu‐
[16] BÖHM R,VONHEHN L,HERDEGEN T,et al. Open‐ lation,2018,137(12):1260-1269.
Vigil FDA-inspection of US American adverse drug [27] GIUGLIANO R P,MACH F,ZAVITZ K,et al. Cogni‐
events pharmacovigilance data and novel clinical applica‐ tive function in a randomized trial of evolocumab[J]. N
tions[J]. PLoS One,2016,11(6):e0157753. Engl J Med,2017,377(7):633-643.
[17] JI H H,TANG X W,DONG Z,et al. Adverse event pro‐ (收稿日期:2022-03-10 修回日期:2022-07-26)
files of anti-CTLA-4 and anti-PD-1 monoclonal antibodies (编辑:舒安琴)
alone or in combination:analysis of spontaneous reports
中国药房 2022年第33卷第19期 China Pharmacy 2022 Vol. 33 No. 19 ·2397·