Page 100 - 202007
P. 100

variants in adult non-Hodgkin’s lymphoma patients:asso-  Gene polymorphisms in folate metabolizing enzymes in
             ciation with toxicity and survival[J]. Haematologica,  adult acute lymphoblastic leukemia:effects on methotrex-
             2007,92(4):478-485.                                 ate-related toxicity and survival[J]. Haematologica,2009,
        [20]  HAASE R,ELSNER K,MERKEL N,et al. High dose         94(10):1391-1398.
             methotrexate treatment in childhood ALL:pilot study on  [31]  PAKAKASAMA S,KANCHANAKAMHAENG K,KA-
             the impact of the MTHFR 677C>T and 1298A>C poly-    JANACHUMPOL S,et al. Genetic polymorphisms of fo-
             morphisms on MTX-related toxicity[J]. Klinische Padiat-  late metabolic enzymes and toxicities of high dose metho-
             rie,2012,224(3):156-159.                            trexate in children with acute lymphoblastic leukemia[J].
        [21]  KARATHANASIS NV,STIAKAKI E,GOULIELMOS              Ann Hematol,2007,86(8):609-611.
             GN,et al. The role of the methylenetetrahydrofolate reduc-  [32]  SHIMASAKI N,MORI T,SAMEJIMA H,et al. Effects
             tase 677 and 1298 polymorphisms in Cretan children with  of methylenetetrahydrofolate reductase and reduced folate
             acute lymphoblastic leukemia[J]. Genetic Testing and Mo-  carrier 1 polymorphisms on high-dose methotrexate-in-
             lecular Biomarkers,2011,15(1/2):5-10.               duced toxicities in children with acute lymphoblastic leu-
        [22]  KOTNIK BF,GRABNAR I,GRABAR PB,et al. Associa-      kemia or lymphoma[J]. Int J Pediatr Hematol Oncol,
             tion of genetic polymorphism in the folate metabolic path-  2006,28(2):64-68.
             way with methotrexate pharmacokinetics and toxicity in  [33]  SUTHANDIRAM S,GAN GG,ZAIN SM,et al. Effect of
             childhood acute lymphoblastic leukaemia and malignant  polymorphisms within methotrexate pathway genes on
             lymphoma[J]. Eur J Clin Pharmacol,2011,67(10):993-  methotrexate toxicity and plasma levels in adults with he-
             1006.                                               matological malignancies[J]. Pharmacogenomics,2014,
        [23]  李天媛,王斌,徐康康,等.急性淋巴细胞白血病患儿亚甲                         15(11):1479-1494.
             基四氢叶酸还原酶基因 C677T 多态性与甲氨蝶呤毒副                    [34]  TANTAWY AA,EL-BOSTANY EA,ADLY AA,et al.
             反应的研究[J].南京医科大学学报(自然科学版),2010,                      Methylene tetrahydrofolate reductase gene polymorphism
             30(3):386-389.                                      in Egyptian children with acute lymphoblastic leukemia
        [24]  李静,王捷,赵军,等.亚甲基四氢叶酸还原酶基因多态性                         [J]. Blood Coagul Fibrinol,2010,21(1):28-34.
             与甲氨蝶呤不良反应的相关性[J].中国临床药理学杂                      [35]  伍艳鹏,贺湘玲,邹润英,等.急性淋巴细胞白血病患儿
             志,2014,30(12):1086-1088.                            MTHFR基因多态性与大剂量甲氨蝶呤化疗后不良反应
        [25]  李静,王捷,郁长治,等.亚甲基四氢叶酸还原酶基因多态                         的关系[J].广东医学,2015,36(3):413-416.
             性与急性淋巴细胞白血病患者甲氨蝶呤化疗药物不良                        [36]  郑苗苗,岳丽杰,陈小文,等.急性淋巴细胞白血病患儿
             反应的相关性研究[J].中国临床药理学杂志,2017,33                       MTHFR基因多态性与大剂量甲氨蝶呤毒副反应的关系
             (17):1634-1636.                                     [J].中国当代儿科杂志,2013,15(3):201-206.
        [26]  廖清船,李晓蕾,刘思婷,等. MTHFR基因多态性及单体                  [37]  焦力,周道斌,王书杰,等.血药浓度监测在大剂量甲氨蝶
             型与大剂量甲氨蝶呤化疗毒性反应的相关性研究[J].中                          呤治疗中的应用价值[J].中国医学科学院学报,2009,31
             华流行病学杂志,2012,33(7):735-739.                        (5):564-566.
        [27]  刘晶霞,陈洁平,谭文,等.亚甲基四氢叶酸还原酶基因多                    [38]  KODIDELA S,SURESH CP,DUBASHI B. Pharmacoge-
             态性与急性淋巴细胞白血病患者甲氨蝶呤化疗毒副反                             netics of methotrexate in acute lymphoblastic leukaemia:
             应的研究[J].中国实验血液学杂志,2008,16(3):488-                   why still at the bench level?[J]. Eur J Clin Pharmacol,
             492.                                                2014,70(3):253-260.
        [28]  LIU SG,LI ZG,CUI L,et al. Effects of methylenetetrahy-  [39]  YAO P,HE X,ZHANG R,et al. The influence of MTH-
             drofolate reductase gene polymorphisms on toxicities dur-  FR genetic polymorphisms on adverse reactions after
             ing consolidation therapy in pediatric acute lymphoblastic  methotrexate in patients with hematological malignancies:
             leukemia in a Chinese population[J]. Leuk Lymphoma,  a meta-analysis[J]. Hematology,2018,24(1):10-19.
             2011,52(6):1030-1040.                          [40]  黄琳,于芝颖,顾群,等.亚甲基四氢叶酸还原酶基因多态
        [29]  聂朝霞,刘岚,崔巍. MTHRF 基因 C677T 多态性与 ALL                 性与甲氨蝶呤不良反应关系的Meta分析[J].中国临床药
             患儿 MTX 血药浓度和毒副反应的相关性[J].医学临床                        理学杂志,2016,32(2):183-185.
             研究,2012,29(2):295-298.                                      (收稿日期:2019-10-21  修回日期:2019-12-21)
        [30]  ONGARO A,DE MATTEI M,DELLA PORTA MG,et al.                                         (编辑:刘明伟)






        ·858  ·  China Pharmacy 2020 Vol. 31 No. 7                                   中国药房    2020年第31卷第7期
   95   96   97   98   99   100   101   102   103   104   105