Page 76 - 《中国药房》2026年10期
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[ 2 ]  BABAR R K,BRESNAHAN R,GILLESPIE C S,et al.        lepsy Behav,2024,151:109601.
               Lacosamide  add-on  therapy  for  focal  epilepsy[J].  Co‐  [14]  LUKKA P B,WOODS M,CHHIM R,et al. Use of real-
               chrane Database Syst Rev,2021,5(5):CD008841.        world  data  and  pharmacometric  modeling  in  support  of
          [ 3 ]  MAO F Q,CHEN S N,HU Y N,et al. Therapeutic drug   lacosamide  dosing  in  pediatric  patients  under  4  years  of
               monitoring  for  lacosamide  in  Chinese  pediatric  patients   age[J]. J Clin Pharmacol,2021,61(7):881-888.
               with epilepsy:focus on clinical effectiveness,tolerability   [15]  KIM  S  E,GU  N,KIM  B  H,et  al.  Pharmacokinetics  of
               and drug interactions[J]. Int J Med Sci,2025,22(5):1150-  lacosamide in healthy Korean male volunteers[J]. Pharma‐
               1157.                                               cology,2012,89(3/4):172-178.
          [ 4 ]  HIEMKE  C,BERGEMANN  N,CLEMENT  H W,et  al.   [16]  SCHAEFER  C,CAWELLO  W,WAITZINGER  J,et  al.
               Consensus  guidelines  for  therapeutic  drug  monitoring  in   Effect of age and sex on lacosamide pharmacokinetics in
               neuropsychopharmacology:update 2017[J]. Pharmacopsy‐  healthy  adult  subjects  and  adults  with  focal  epilepsy[J].
               chiatry,2018,51(1/2):e1.                            Clin Drug Investig,2015,35(4):255-265.
          [ 5 ]  WOODS  M,PHELPS  S  J,CHRISTENSEN  M  L,et  al.   [17]  WU R Y,LIU S S,ZHAO Z G,et al. Population pharma‐
               Impact  of  age  and  concurrent  antiseizure  medication  use   cokinetic  model  of  lacosamide  in  Chinese  children  and
               on  lacosamide  dose  to  concentration  ratio  and  dosing  in   adults with epilepsy[J/OL]. Ther Drug Monit,2025[2026-
               pediatric  patients[J].  J  Pediatr  Pharmacol Ther,2024,29  01-01]. https://pubmed.ncbi.nlm.nih.gov/40960184/.DOI:
              (5):514-524.                                         10.1097/FTD. 0000000000001385.
          [ 6 ]  European Medicines Agency. Vimpat(lacosamide):sum‐  [18]  YU L Y,MAO F Q,CHEN S N,et al. Development and
               mary  of  product  characteristics[EB/OL].(2025-05-08)  validation  of  a  population  pharmacokinetic  model  for
               [2026-05-11].  https://www. ema. europa. eu/en/medicines/  lacosamide in adult patients with epilepsy to inform preci‐
                                                                   sion dosing[J]. BMC Pharmacol Toxicol,2026,27(1):61.
               human/EPAR/vimpat.
          [ 7 ]  ETTE E I,WILLIAMS P J. Population pharmacokinetics   [19]  CHHUN S,JULLIEN V,REY E,et al. Population phar‐
               Ⅰ:background,concepts,and models[J]. Ann Pharmaco‐  macokinetics  of  levetiracetam  and  dosing  recommenda‐
                                                                   tion in children with epilepsy[J]. Epilepsia,2009,50(5):
               ther,2004,38(10):1702-1706.
                                                                   1150-1157.
          [ 8 ]  李莹,王鸣璐,王成彬,等. 左乙拉西坦群体药动学系统
                                                              [20]  李红健,孙岩,赵婷,等. 新疆癫痫患儿拉考沙胺血药浓
               分析[J]. 中国药学杂志,2023,58(7):632-637.
                                                                   度的影响因素探讨[J]. 中国医院药学杂志,2021,41
          [ 9 ]  MOONS  K  G  M,WOLFF  R  F,RILEY  R  D,et  al.
                                                                  (13):1323-1326,1346.
               PROBAST:a tool to assess risk of bias and applicability
                                                              [21]  赵婷,孙岩,张惠兰,等. 拉考沙胺在癫痫患儿中的临床
               of  prediction  model  studies:explanation  and  elaboration
                                                                   疗效和血药浓度研究[J]. 中国药学杂志,2022,57(5):
               [J]. Ann Intern Med,2019,170(1):W1-W33.
                                                                   403-407.
          [10]  李芷凡,刘明,赵文硕,等 . PROBAST+AI:基于人工智
                                                              [22]  ROBERTI R,PALLERIA C,NESCI V,et al. Pharmacoki‐
               能或回归方法的预测模型研究质量、偏倚风险及适用性
                                                                   netic  considerations  about  antiseizure  medications  in  the
               评估工具解读[J]. 中国循证医学杂志,2025,25(9):
                                                                   elderly[J].  Expert  Opin  Drug  Metab  Toxicol,2020,16
               1107-1116.
                                                                  (10):983-995.
          [11]  WINKLER  J,SCHOEMAKER  R,STOCKIS A.  Popula‐
                                                              [23]  FUKUSHIMA Y,YAMAMOTO Y,YAMAZAKI E,et al.
               tion pharmacokinetics of adjunctive lacosamide in pedia-
                                                                   Change  in  the  pharmacokinetics  of  lacosamide  before,
               tric patients with epilepsy[J]. J Clin Pharmacol,2019,59
                                                                   during,and after pregnancy[J]. Seizure,2021,88:12-14.
              (4):541-547.
                                                              [24]  习志洁,孙红斌. 女性癫痫患者围妊娠期癫痫管理的研
          [12]  WINKLER  J,SCHOEMAKER  R,STOCKIS A.  Model-
                                                                   究进展[J]. 四川医学,2017,38(1):109-113.
               ing  and  simulation  for  the  evaluation  of  dose  adaptation
                                                              [25]  李玥,郭宏丽,赵越桃,等. 拉考沙胺在儿童癫痫中的治
               rules  of  intravenous  lacosamide  in  children[J].  Epilepsy
                                                                   疗药物监测研究进展[J]. 中国药学杂志,2023,58(19):
               Res,2019,149:13-16.
                                                                   1731-1735.
          [13]  WANG  J,MEI  Y,LIANG  S,et  al.  How  to  handle  a
                                                                            (收稿日期:2026-01-20  修回日期:2026-05-12)
               missed or delayed dose of lacosamide in pediatric patients
                                                                                                  (编辑:孙    冰)
               with epilepsy? A mode-informed individual dosing[J]. Epi‐


          · 1306 ·    China Pharmacy  2026 Vol. 37  No. 10                            中国药房  2026年第37卷第10期
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