Page 78 - 《中国药房》2026年8期

于该信号轴下游，受 Notch1/Hes1 调控而非反馈调节上 [ 8 ] DING H Z，CHEN H J，DOU L R，et al. CircRELL1 pro‐
游。这一回复实验充分证实了Prdx1在TFRD调控通路 motes osteoarthritis progression by regulating miR-200c-
中的关键作用，也证实了 TFRD 对 Notch1/Hes1 信号轴 3p[J]. Heliyon，2024，10（14）：e34251.
的直接调控作用。 [ 9 ] MA F，WANG L X，CHI H，et al. Exploring the therapeu‐
综上所述，TFRD可能通过激活Notch1/Hes1信号轴 tic potential of MIR-140-3p in osteoarthritis：targeting
CILP and ferroptosis for novel treatment strategies[J].
上调Prdx1表达，进而抑制LPS诱导的软骨细胞凋亡、促
Cell Prolif，2025，58（11）：e70018.
进其保护性自噬，从而改善软骨代谢稳态。然而，C28/I2
[10] CHEN G Y，LIU X Y，YAN X E，et al. Total flavonoids of
细胞系在基质合成能力等方面与原代软骨细胞存在差
Rhizoma Drynariae treat osteoarthritis by inhibiting ara‐
异，且目前结论仅基于细胞实验，尚未在动物体内验证
chidonic acid metabolites through AMPK/NF-κB pathway
其效果。后续研究将在原代软骨细胞及OA动物模型中 [J]. J Inflamm Res，2023，16：4123-4140.
进行深入验证，以全面阐明 TFRD 的作用机制，为其临 [11] JIANG N N，JIN H，YANG K，et al. The mechanism of
床转化提供更可靠的实验参考。 metformin combined with total flavonoids of Rhizoma
参考文献 Drynariae on ovariectomy-induced osteoporotic rats[J].
[ 1 ] CHEN H W，ZHANG L，SHI X R，et al. Evaluation of Biomed Pharmacother，2023，165：115181.
osteoarthritis disease burden in China during 1990-2019 [12] ZHUANG H M，REN X S，ZHANG Y L，et al. β -Hy‐
and forecasting its trend over the future 25 years[J]. Arthritis droxybutyrate enhances chondrocyte mitophagy and reduces
Care Res，2024，76（7）：1006-1017. cartilage degeneration in osteoarthritis via the HCAR2/
[ 2 ] LI J，SUN F R，ZHANG Y J，et al. MiR-103-3p regulates AMPK/PINK1/Parkin pathway[J]. Aging Cell，2024，23
chondrocyte autophagy，apoptosis，and ECM degradation （11）：e14294.
through the PI3K/Akt/mTOR pathway by targeting CPEB3 [13] WANG H，ZHOU J，LU Y，et al. The interplay between
[J]. J Orthop Surg Res，2025，20（1）：324. autophagy and programmed cell death in osteoarthritis：
[ 3 ] LU Y F，ZHOU J，WANG H，et al. Endoplasmic reticulum insights into mechanisms and therapeutic targets[J]. Mol
stress-mediated apoptosis and autophagy in osteoarthritis： Cell Biochem，2025，480（8）：4627-4646.
from molecular mechanisms to therapeutic applications[J]. [14] WANG L W，ZHANG W，WANG Z F，et al. Astragalus
Cell Stress Chaperones，2024，29（6）：805-830. polysaccharide alleviated septic associated acute kidney
[ 4 ] LI W，ZHANG Z C，LI Y Y，et al. Effects of total flavo‐ injury through dual mechanisms of RIPK1-dependent
noids of Rhizoma Drynariae on biochemical indicators of necroptosis and autophagy in macrophage[J]. Phytother
bone metabolism：a systematic review and meta-analysis Res，2026. DOI：10.1002/ptr.70309.
[J]. Front Pharmacol，2024，15：1443235. [15] GE X，YANG G M，ZHANG X L，et al. Isoliensinine
[ 5 ] SU H，LIU L Y，YAN Z C，et al. Therapeutic potential of inhibits mitophagy and sensitizes T cell malignancies for
total flavonoids of Rhizoma Drynariae：inhibiting adipo‐ STING-mediated NK clearance[J]. Acta Pharmacol Sin，
genesis and promoting osteogenesis via MAPK/HIF-1α 2026，47（1）：242-254.
pathway in primary osteoporosis[J]. J Orthop Surg Res， [16] SUN H H，LI Y L，JIANG H，et al. PRDX1 influences the
2025，20（1）：260. occurrence and progression of liver cancer by inhibiting
[ 6 ] MENG P L，LIU H，LIU L，et al. Activation of notch sig‐ mitochondrial apoptosis pathway[J]. Cell J，2022，24（11）：
naling pathway is involved in extracellular matrix degrada‐ 657-664.
tion in human induced pluripotent stem cells chondrocytes [17] KUMAR Y，BISWAS T，THACKER G，et al. BMP
induced by HT-2 toxin[J]. Food Chem Toxicol，2024，189： signaling-driven osteogenesis is critically dependent on
114724. Prdx-1 expression-mediated maintenance of chondrocyte
[ 7 ] LI J W，WANG R L，XU J，et al. Methylene blue prevents prehypetrophy[J]. Free Radic Biol Med，2018，118：1-12.
osteoarthritis progression and relieves pain in rats via up‐ （收稿日期：2025-09-15 修回日期：2026-03-26）
regulation of Nrf2/PRDX1[J]. Acta Pharmacol Sin，2022， （编辑：邹丽娟）
43（2）：417-428.

· 1032 · China Pharmacy 2026 Vol. 37 No. 8 中国药房 2026年第37卷第8期