Page 38 - 《中国药房》2026年3期
P. 38

AMPK/SREBP-1/GPAT 信号通路的活性单体成分,从而                         Pursh extract ameliorates alcohol-related fatty liver disease
          为NAFLD的治疗提供靶向策略和理论基础。                                    in mice via the SIRT1/AMPK signaling axis[J]. Heliyon,
          参考文献                                                     2024,10(11):e31195.
                                                              [13]  隆逸瑶,刘渝港,夏会平,等. 三萜皂苷抗肥胖及其作用
          [ 1 ]  杨金彪,陈星彤,周云越,等. 基于Nrf2信号通路中药对
                                                                   机 制 的 研 究 进 展 [J].  食 品 工 业 科 技 ,2022,43(7):
               代谢相关脂肪性肝病预防及治疗作用研究进展[J]. 药物
                                                                   445-456.
               评价研究,2024,47(11):2681-2687.
                                                              [14]  XIANG Q W,WEN J Y,ZHOU Z H,et al. Effect of hy‐
          [ 2 ]  LE M H,YEO Y H,LI X H,et al. 2019 global NAFLD
                                                                   droxy-α-sanshool on lipid metabolism in liver and hepato‐
               prevalence:a systematic review and meta-analysis[J]. Clin
                                                                   cytes  based  on AMPK  signaling  pathway[J].  Phytomedi‐
               Gastroenterol Hepatol,2022,20(12):2809-2817.e28.
                                                                   cine,2024,132:155849.
          [ 3 ]  CHRYSAVGIS    L,   GIANNAKODIMOS       I,
                                                              [15]  LI Y,XU S Q,MIHAYLOVA M M,et al. AMPK phos‐
               DIAMANTOPOULOU P,et al. Non-alcoholic fatty liver
                                                                   phorylates  and  inhibits  SREBP  activity  to  attenuate  he‐
               disease  and  hepatocellular  carcinoma:clinical  challenges
                                                                   patic steatosis and atherosclerosis in diet-induced insulin-
               of  an  intriguing  link[J]. World  J  Gastroenterol,2022,28
                                                                   resistant mice[J]. Cell Metab,2011,13(4):376-388.
              (3):310-331.
                                                              [16]  FANG S J,MA Y X,YANG S H,et al. The components of
          [ 4 ]  高改娅,李莎,薛敬东,等. 非酒精性脂肪性肝病中医证
                                                                   Buyang  huanwu  decoction  with  UPLC-MS[J].  Nat  Prod
               型及证素研究[J]. 临床肝胆病杂志,2021,37(1):89-93.
                                                                   Commun,2024,19(9):1934578X241275820.
          [ 5 ]  陈欢,徐陆周,黄芳 . 中药基于“肠-肝轴”防治非酒精性
                                                              [17]  ZHANG S C,CUI Z W,ZHANG H,et al. Pea albumin ex‐
               脂肪性肝病的研究进展[J]. 药学进展,2024,48(11):
                                                                   tracted  from  pea (Pisum  sativum  L.)  seeds  ameliorates
               849-859.
                                                                   high-fat-diet-induced  non-alcoholic  fatty  liver  disease  by
          [ 6 ]  潘雨晴,毛傲洁,于楚楚,等. 中药有效成分及其复方防
                                                                   regulating lipogenesis and lipolysis pathways[J]. Nutrients,
               治非酒精性脂肪性肝病的现状与展望[J]. 临床肝胆病杂
                                                                   2024,16(14):2232.
               志,2024,40(10):1933-1941.
                                                              [18]  RAJENDRAN  R,SUMAN  S,DIVAKARAN  S  J,et  al.
          [ 7 ]  钱煜昊,卜献忠,郭晓辉,等.基于Nrf2/HO-1通路介导的
                                                                   Sesaminol  alters  phospholipid  metabolism  and  alleviates
               铁死亡探讨补阳还五汤对脊髓损伤的保护作用[J/OL].
                                                                   obesity-induced  NAFLD[J].  FASEB  J,2024,38(14):
               中国实验方剂学杂志,2025:1-15[2025-09-03]. https://
                                                                   e23835.
               xueshu.baidu.com/ndscholar/browse/detail paperid=177q-
                                                              [19]  YAO W J,FAN M C,QIAN H F,et al. Quinoa polyphe‐
               0js0gj3k06p0g95f0xs0v9362921.
                                                                   nol extract alleviates non-alcoholic fatty liver disease via
          [ 8 ]  GUO J F,ZHANG Y W,ZHOU R,et al. Deciphering the
                                                                   inhibiting lipid accumulation,inflammation and oxidative
               molecular mechanism of Buyang huanwu decoction in in‐
                                                                   stress[J]. Nutrients,2024,16(14):2276.
               terference with diabetic pulmonary fibrosis via regulating
                                                              [20]  YUAN  Z  S,TIAN  Y,ZHANG  C,et  al.  Integration  of
               oxidative stress and lipid metabolism disorder[J]. J Pharm   systematic  review,lipidomics  with  experiment  verifica‐
               Biomed Anal,2024,243:116061.
                                                                   tion reveals abnormal sphingolipids facilitate diabetic reti‐
          [ 9 ]  王昌明,史永奋,王丹华 . 补阳还五汤加减治疗脂肪肝                        nopathy by inducing oxidative stress on RMECs[J]. Bio‐
               59例临床疗效观察[J]. 中国中西医结合消化杂志,2003,                     chim  Biophys  Acta  Mol  Cell  Biol  Lipids,2023,1868
               11(2):88-89.                                       (11):159382.
          [10]  YANG  S  H,ZHANG  Y  K,LIU  X  X,et  al.  Effects  of       [21]  TAN  H W,MI  N,TONG  F  L,et  al.  Lactucopicrin  pro‐
               different  components  of  Buyang  huanwu  tang  on  the   motes fatty acid β-oxidation and attenuates lipid accumu‐
               PPARγ/LXRα/ABCA1  pathway  in  hypercholesterolemia   lation through adenosine monophosphate-activated protein
               mouse model[J]. Int J Genomics,2025,2025:9595757.   kinase activation in free fatty acid-induced human hepato‐
          [11]  BADI R M,MOSTAFA D G,KHALEEL E F,et al. Res‐       blastoma  cancer  cells[J].  Food  Sci  Nutr,2024,12(8):
               veratrol protects against hepatic insulin resistance in a rat’s   5357-5372.
               model  of  non-alcoholic  fatty  liver  disease  by  down-  [22]  宓伟,于敏,李宁,等 . 基于 AMPK/SREBP-1c 分子通路
               regulation of GPAT-1 and DGAT2 expression and inhibi‐  的山楂原花青素调控脂质代谢机制[J]. 食品科学,2023,
               tion of PKC membranous translocation[J]. Clin Exp Phar‐  44(15):129-136.
               macol Physiol,2019,46(6):545-555.                            (收稿日期:2025-07-21  修回日期:2026-01-02)
          [12]  ZHUGE H,PAN Y,LAI S L,et al. Penthorum chinense                                   (编辑:唐晓莲)







          · 304 ·    China Pharmacy  2026 Vol. 37  No. 3                               中国药房  2026年第37卷第3期
   33   34   35   36   37   38   39   40   41   42   43