Page 132 - 《中国药房》2025年23期
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者预后的临床研究[J]. 中国肺癌杂志,2018,21(1):1-7.                 randomization  and  colocalization  analysis  reveal  novel
          [17]  YU S S,YAN J J,FANG Y,et al. Effect of thymectomy   drug  targets  for  myasthenia  gravis[J].  Hum  Genomics,
               on the frequencies of peripheral regulatory B and T lym‐  2024,18(1):43.
               phocytes in patients with myasthenia gravis:a pilot study  [29]  HOWARD  J  F,UTSUGISAWA  K,BENATAR  M,et  al.
               [J]. Int J Neurosci,2024,134(11):1210-1219.         Safety and efficacy of eculizumab in anti-acetylcholine re‐
          [18]  GARRED P,TENNER A J,MOLLNES T E. Therapeutic       ceptor  antibody-positive  refractory  generalised  myasthe‐
               targeting of the complement system:from rare diseases to   nia  gravis (REGAIN):a  phase  3,randomised,double-
               pandemics[J]. Pharmacol Rev,2021,73(2):792-827.     blind,placebo-controlled,multicentre  study[J].  Lancet
          [19]  AZOULAY E,ZUBER J,BOUSFIHA A A,et al. Comple‐      Neurol,2017,16(12):976-986.
               ment  system  activation:bridging  physiology,pathophy-    [30]  NARAYANASWAMI  P,SANDERS  D  B,WOLFE  G,
               siology,and  therapy[J].  Intensive  Care  Med,2024,50  et al. International consensus guidance for management of
              (11):1791-1803.                                      myasthenia  gravis:2020  update[J].  Neurology,2021,96
          [20]  HOWARD J F,BRESCH S,GENGE A,et al. Safety and     (3):114-122.
               efficacy  of  zilucoplan  in  patients  with  generalised  myas‐  [31]  王莉,周翔鱼. 重症肌无力免疫治疗研究进展[J]. 临床医
               thenia  gravis (RAISE):a  randomised,double-blind,  学进展,2024(5):2364-2374.
               placebo-controlled,phase  3  study[J].  Lancet  Neurol,  [32]  ZHU L N,HOU H M,WANG S,et al. FcRn inhibitors:a
               2023,22(5):395-406.                                 novel  option  for  the  treatment  of  myasthenia  gravis[J].
          [21]  HOWARD J F,BRIL V,VU T,et al. Safety,efficacy,and   Neural Regen Res,2023,18(8):1637-1644.
               tolerability  of  efgartigimod  in  patients  with  generalised   [33]  FUCHS L,SHELLY S,VIGISER I,et al. Real-world ex‐
               myasthenia gravis (ADAPT):a multicentre,randomised,  perience  with  efgartigimod  in  patients  with  myasthenia
               placebo-controlled,phase 3 trial[J]. Lancet Neurol,2021,  gravis[J]. J Neurol,2024,271(6):3462-3470.
               20(7):526-536.                                 [34]  SINGER M,KHELLA S,BIRD S,et al. Single institution
          [22]  MANTEGAZZA R,ANTOZZI C. When myasthenia gra‐       experience with efgartigimod in patients with myasthenia
               vis is deemed refractory:clinical signposts and treatment   gravis:patient  selection,dosing  schedules,treatment  re‐
               strategies[J].  Ther  Adv  Neurol  Disord, 2018, 11:  sponse,and  adverse  events[J].  Muscle  Nerve,2024,69
               1756285617749134.                                  (1):87-92.
          [23]  CHAYANOPPARAT  S, BANYATCHAROEN  P,           [35]  YAN C,YUE Y X,GUAN Y Z,et al. Batoclimab vs. pla‐
               JITPRAPAIKULSAN J,et al. Efficacy and safety of ritu-   cebo  for  generalized  myasthenia  gravis:a  randomized
               ximab  in  anti-MuSK  myasthenia  gravis:a  systematic  re‐  clinical trial[J]. JAMA Neurol,2024,81(4):336-345.
               view and meta-analysis[J]. Sci Rep,2025,15(1):7219.  [36]  BRIL  V,DRUŻDŻ A,GROSSKREUTZ  J,et  al.  Safety
          [24]  PAUL  F,CARTRON  G.  Infusion-related  reactions  to   and  efficacy  of  rozanolixizumab  in  patients  with  gene-
               rituximab:frequency,mechanisms  and  predictors[J].  Ex‐  ralised  myasthenia  gravis (MycarinG):a  randomised,
               pert Rev Clin Immunol,2019,15(4):383-389.           double-blind,placebo-controlled,adaptive  phase  3  study
          [25]  LI S S,ZHANG Z X,LIU Z J. Therapeutic effect of ofatu‐  [J]. Lancet Neurol,2023,22(5):383-394.
               mumab in patients with myasthenia gravis:immunoregula‐  [37]  GILHUS N E,ANDERSEN H,ANDERSEN L K,et al.
               tion of follicular T helper cells and T helper type 17 cells  Generalized myasthenia gravis with acetylcholine receptor
               [J]. Front Neurol,2023,14:1278250.                  antibodies:a  guidance  for  treatment[J].  Eur  J  Neurol,
          [26]  HEWETT K,SANDERS D B,GROVE R A,et al. Ran‐         2024,31(5):e16229.
               domized  study  of  adjunctive  belimumab  in  participants   [38]  HABIB A A,ZHAO C B,ABAN I,et al. Safety and effi‐
               with generalized myasthenia gravis[J]. Neurology,2018,  cacy of satralizumab in patients with generalised myasthe‐
               90(16):e1425-e1434.                                 nia gravis (LUMINESCE):a randomised,double-blind,
          [27]  南京瑞科生物科技股份有限公司.泰它西普临床研究与                           multicentre,placebo-controlled  phase  3  trial[J].  Lancet
               作用机制解析[EB/OL]. [2025-06-22]. https://www.reme‐      Neurol,2025,24(2):117-127.
               gen.cn/index.php?v=show&cid=39&id=2645.                      (收稿日期:2025-07-10  修回日期:2025-11-27)
          [28]  OUYANG Y  Z,CHEN Y,CHEN  K  Z,et  al.  Mendelian                                  (编辑:胡晓霖)







          · 3006 ·    China Pharmacy  2025 Vol. 36  No. 23                            中国药房  2025年第36卷第23期
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