Page 136 - 《中国药房》2025年20期

[14] 刘昌顺，胡艳楠，夏婷，等 . 香连丸中 8 种功效成分在小 [27] ZHANG J X，HU Y X，LIU Y，et al. Xianglian pill alle-
鼠体内的组织分布[J]. 世界科学技术-中医药现代化， viates ulcerative colitis by inhibiting M1 macrophage polari-
2021，23（3）：686-692. zation via modulation of energy metabolite itaconate[J].
[15] DICARLO M，TETI G，VERNA G，et al. Quercetin expo‐ Phytomedicine，2024，135：156179.
sure suppresses the inflammatory pathway in intestinal [28] WU D S，CAO H，ZHANG Y，et al. Shaoyaotang treats ul‐
organoids from Winnie mice[J]. Int J Mol Sci，2019，20 cerative colitis by inhibiting HIF-1α and regulating Th17/
（22）：5771. Treg balance[J]. Chin J Exp Tradit Med Formulae，2021，
[16] MOPARTHI L，KOCH S. Wnt signaling in intestinal in‐ 27（16）.
flammation[J]. Differentiation，2019，108：24-32. [29] 杨乐，徐梦婷，蔡琳玲，等. UHPLC-TOF-MS结合网络药
[17] LUO Z Y，HU Y X，QIU C W，et al. Coptidis Rhizoma 理学与实验验证探讨香连丸治疗溃疡性结肠炎的作用
processed with Evodia rutaecarpa improves the effect on 机制[J]. 中国药学杂志，2023，58（12）：1084-1092.
ulcerative colitis by increasing intestinal energy metabo‐ [30] WANG J Q，JEELALL Y S，FERGUSON L L，et al. Toll-
lites alpha-ketoglutarate and Lactobacillus reuteri[J]. like receptors and cancer：MyD88 mutation and inflamma‐
Phytomedicine，2023，121：155115. tion[J]. Front Immunol，2014，5：367.
[18] HARRIS C，FRASER CUMMINGS J R. JAK1 inhibition [31] DAI Y X，LU Q L，LI P Y，et al. Xianglian pill attenuates
and inflammatory bowel disease[J]. Rheumatology （Oxford）， ulcerative colitis through TLR4/MyD88/NF-κB signaling
2021，60（Suppl. 2）：ii45-ii51. pathway[J]. J Ethnopharmacol，2023，300：115690.
[19] LIU C S，XIA T，LUO Z Y，et al. Network pharmacology [32] NIGHOT P K，HU C A，MA T Y. Autophagy enhances in‐
and pharmacokinetics integrated strategy to investigate the testinal epithelial tight junction barrier function by tar-
pharmacological mechanism of Xianglian pill on ulcera- geting claudin-2 protein degradation[J]. J Biol Chem，
tive colitis[J]. Phytomedicine，2021，82：153458. 2015，290（11）：7234-7246.
[20] LI J Y，XIAO J，GAO M，et al. IRF/type Ⅰ IFN signaling [33] BENTO C F，RENNA M，GHISLAT G，et al. Mammalian
serves as a valuable therapeutic target in the pathogenesis autophagy：how does it work? [J]. Annu Rev Biochem，
of inflammatory bowel disease[J]. Int Immunopharmacol， 2016，85：685-713.
2021，92：107350. [34] Frontiers Editorial Office. Retracted：Xianglian pill sup‐
[21] TIAN Y，YANG C M，YAO Q Y，et al. Procyanidin B2 ac‐ presses inflammation and protects intestinal epithelial bar‐
tivates PPARγ to induce M2 polarization in mouse macro‐ rier by promoting autophagy in DSS induced ulcerative
phages[J]. Front Immunol，2019，10：1895. colitis mice[J]. Front Pharmacol，2023，14：1289227.
[22] ZHOU H F，YANG C，LI J Y，et al. Quercetin serves as [35] GUO X Y，LIU X J，HAO J Y. Gut microbiota in ulcera-
the major component of Xianglian pill to ameliorate ulcer‐ tive colitis：insights on pathogenesis and treatment[J]. J
ative colitis via tipping the balance of STAT1/PPARγ and Dig Dis，2020，21（3）：147-159.
dictating the alternative activation of macrophage[J]. J [36] LIU C S，HU Y X，LUO Z Y，et al. Xianglian pill modu‐
Ethnopharmacol，2023，313：116557. lates gut microbial production of succinate and induces
[23] LEE S，KARKI R，WANG Y Q，et al. AIM2 forms a com‐ regulatory T cells to alleviate ulcerative colitis in rats[J]. J
plex with pyrin and ZBP1 to drive PANoptosis and host Ethnopharmacol，2023，303：116007.
defence[J]. Nature，2021，597（7876）：415-419. [37] CHANG J，LEONG R W，WASINGER V C，et al. Im‐
[24] 何红霞，范恒，杨佳. 香连丸对溃疡性结肠炎小鼠泛凋亡 paired intestinal permeability contributes to ongoing
途径的影响[J]. 华中科技大学学报（医学版），2024，53 bowel symptoms in patients with inflammatory bowel di-
（6）：717-722. sease and mucosal healing[J]. Gastroenterology，2017，153
[25] YANG Z H，LIN S S，FENG W Y，et al. A potential thera‐ （3）：723-731.e1.
peutic target in traditional Chinese medicine for ulcerative [38] YANG L J，ZHANG Q，HUANG J Y，et al. Xianglian pill
colitis：macrophage polarization[J]. Front Pharmacol， ameliorates antibiotic-associated diarrhea by restoring in‐
2022，13：999179. testinal microbiota and attenuating mucosal damage[J]. J
[26] WANG S L，LIU G H，LI Y R，et al. Metabolic reprogram‐ Ethnopharmacol，2021，264：113377.
ming induces macrophage polarization in the tumor micro‐ （收稿日期：2025-05-30 修回日期：2025-09-23）
environment[J]. Front Immunol，2022，13：840029. （编辑：邹丽娟）

· 2614 · China Pharmacy 2025 Vol. 36 No. 20 中国药房 2025年第36卷第20期