Page 29 - 《中国药房》2025年18期
P. 29

[ 2 ]  HAN B F,ZHENG R S,ZENG H M,et al. Cancer inci‐  [15]  WANG S H,YANG Y Q,LIN J H,et al. Astragalin ac‐
              dence  and  mortality  in  China,2022[J].  J  Natl  Cancer   tives autophagy and inhibits apoptosis of astrocytes in AD
              Cent,2024,4(1):47-53.                               mice  via  down-regulating  Fas/FasL-VDAC1  pathway[J].
          [ 3 ]  国家卫生健康委员会医政司 . 原发性肝癌诊疗指南:                        Free Radic Biol Med,2025,232:72-85.
              2024年版[J]. 中华消化外科杂志,2024,23(4):429-478.        [16]  WANG X C,SU Y J,LAN B,et al. USP22 promotes the
          [ 4 ]  ANWANWAN  D,SINGH  S  K,SINGH  S,et  al.  Chal‐  proliferation  and  Sorafenib  resistance  of  hepatocellular
              lenges  in  liver  cancer  and  possible  treatment  approaches  carcinoma  cells  via  its  deubiquitinase  activity[J].  Clin
              [J]. Biochim Biophys Acta Rev Cancer,2020,1873(1):  Transl Med,2025,15(5):e70324.
              188314.                                        [17]  WANG K L,CHEN Q,SHAO Y Y,et al. Anticancer ac‐
          [ 5 ]  NAEEM A,HU P Y,YANG M,et al. Natural products as   tivities of TCM and their active components against tumor
              anticancer  agents:current  status  and  future  perspectives  metastasis[J]. Biomed Pharmacother,2021,133:111044.
              [J]. Molecules,2022,27(23):8367.               [18]  YANG R Y,GAO W H,WANG Z B,et al. Polyphyllin Ⅰ
          [ 6 ]  华栋,刘杨,王夏茵,等. 宽叶重楼化学成分研究[J]. 中南                   induced ferroptosis to suppress the progression of hepato‐
              药学,2015,13(1):43-46.                                cellular carcinoma through activation of the mitochondrial
          [ 7 ]  YAO M N,LI R L,YANG Z F,et al. PP9,a steroidal sapo‐  dysfunction via Nrf2/HO-1/GPX4 axis[J]. Phytomedicine,
              nin,induces G2/M arrest and apoptosis in human colorec‐  2024,122:155135.
              tal  cancer  cells  by  inhibiting  the  PI3K/Akt/GSK3β  path‐  [19]  施亚敏,周政,边猛,等. 重楼皂苷Ⅱ通过调控ROS和内
              way[J]. Chem Biol Interact,2020,331:109246.         质网应激促进骨肉瘤细胞自噬的研究[J]. 中国药理学通
          [ 8 ]  STEFANOWICZ-HAJDUK  J, BARTOSZEWSKI  R,          报,2024,40(12):2340-2346.
              BARTOSZEWSKA  S,et  al.  Pennogenyl  saponins  from   [20]  闫本纯,何春艳,李宏伟,等. 桃叶珊瑚苷对前列腺癌的
              Paris  quadrifolia  L.  induce  extrinsic  and  intrinsic  path‐  抑制作用及机制的体内外研究[J]. 中国药房,2024,35
              way of apoptosis in human cervical cancer HeLa cells[J].   (13):1618-1623.
              PLoS One,2015,10(8):e0135993.                  [21]  EMDAD  L,BHOOPATHI  P,TALUKDAR  S,et  al.  Re‐
          [ 9 ]  ZOU  X  L,HUANG  W  F.  TTB2  induces  apoptosis  in      cent insights into apoptosis and toxic autophagy:the roles
              Ewing  sarcoma  cells[J].  Exp  Ther  Med,2018,16(2):  of  MDA-7/IL-24,a  multidimensional  anti-cancer  thera‐
              1021-1025.                                          peutic[J]. Semin Cancer Biol,2020,66:140-154.
          [10]  ZHANG S,LU Y Y,LI H,et al. A steroidal saponin form   [22]  LI C Y,CHEN H B,CHEN X J,et al. Identification of in‐
              Paris  vietnamensis(Takht.)reverses  temozolomide  resis‐  flammatory response-related molecular mechanisms based
              tance in glioblastoma cells via inducing apoptosis through   on the ATM/ATR/p53 pathway in tumor cells[J]. Comput
              ROS/PI3K/Akt pathway[J]. Biosci Trends,2020,14(2):  Biol Med,2024,180:108776.
              123-133.                                       [23]  王虎平,陈怡琴,杨娇,等 . 黑逍遥散调控 Fas/FasL/Cas‐
          [11]  仲光勇,王昌利,宋延平,等 . 陕重楼甾体皂苷类单体 B                      pase-8/Caspase-3 信号通路对 AD 大鼠神经元细胞凋亡
              (BM-61)对SMMC-7721细胞增殖的影响[J]. 河南中医,                  的影响[J]. 中国实验方剂学杂志,2024,30(17):18-26.
              2016,36(4):718-720.                            [24]  ALI  ABD  EL-HAFEEZ  A,MARZOUK  H  M  M,
          [12]  ZHAO J H,LIANG K Y,ZHONG H,et al. A cold-water    ABDELHAMID M A A,et al. Anti-cancer effect of Hyo‐
              polysaccharide-protein complex from Grifola frondosa ex‐  scyamus  muticus  extract  via  its  activation  of  Fas/FasL-
              hibited  antiproliferative  activity  via  mitochondrial  apop‐  ASK1-p38 pathway[J]. Biotechnol Bioprocess Eng,2022,
              totic and Fas/FasL pathways in HepG2 cells[J]. Int J Biol   27(5):833-845.
              Macromol,2022,218:1021-1032.                   [25]  WANG B,NIE C H,XU J,et al. Bigelovin inhibits hepato‐
          [13]  WU X B,LAI C H,HO Y J,et al. Anti-apoptotic effects   cellular  carcinoma  cell  growth  and  metastasis  by  regula-
              of diosgenin on ovariectomized hearts[J]. Steroids,2022,  ting  the  MAPT-mediated  Fas/FasL  pathway[J].  Neo‐
              179:108980.                                         plasma,2023,70(2):208-215.
          [14]  方海雁,龚晓燕,洪星辉,等 . 重楼总皂苷对人胃癌                                   (收稿日期:2025-03-25  修回日期:2025-08-06)
              MKN-45 细胞凋亡及 Fas/FasL 信号通路的影响[J]. 中国                                                (编辑:张元媛)
              中药杂志,2015,40(7):1388-1391.










          中国药房  2025年第36卷第18期                                              China Pharmacy  2025 Vol. 36  No. 18    · 2243 ·
   24   25   26   27   28   29   30   31   32   33   34