Page 132 - 《中国药房》2025年15期
P. 132
Biomed Pharmacother,2024,175:116729. formin,improves cognitive function in aged mice by re‐
[25] ASHLEIGH T,SWERDLOW R H,BEAL M F. The role ducing the proinflammatory cytokine interleukin-6[J]. Mi‐
of mitochondrial dysfunction in Alzheimer’s disease crobiome,2023,11(1):120.
pathogenesis[J]. Alzheimers Dement,2023,19 (1) : [34] AHMADI S,RAZAZAN A,NAGPAL R,et al. Metformin
333-342. reduces aging-related leaky gut and improves cognitive
[26] FENG J,WANG X H,YE X C,et al. Mitochondria as an function by beneficially modulating gut microbiome/gob‐
important target of metformin:the mechanism of action, let cell/mucin axis[J]. J Gerontol A Biol Sci Med Sci,
toxic and side effects,and new therapeutic applications[J]. 2020,75(7):e9-e21.
Pharmacol Res,2022,177:106114. [35] CERASUOLO M,DI MEO I,AURIEMMA M C,et al.
[27] SONG Y S,LIU Z Y,ZHU X Y,et al. Metformin alle- Exploring the dynamic changes of brain lipids,lipid rafts,
viates the cognitive impairment caused by aluminum by and lipid droplets in aging and Alzheimer’s disease[J].
improving energy metabolism disorders in mice[J]. Biomolecules,2024,14(11):1362.
Biochem Pharmacol,2022,202:115140. [36] WEN H C,TIAN H H,LIU C,et al. Metformin and cyani‐
[28] FENG Y Y,XU Z Y,JIN H F,et al. Metformin amelio‐ din 3-O-galactoside from Aronia melanocarpa synergisti‐
rates mitochondrial damage induced by C9orf72 poly cally alleviate cognitive impairment in SAMP8 mice[J].
(GR) via upregulating AKT phosphorylation[J]. J Cell Food Funct,2021,12(21):10994-11008.
Biochem,2024,125(3):e30526. [37] WINOCUR G,JOHNSTON I,CASTEL H. Chemo‐
[29] SKEMIENE K,REKUVIENE E,JEKABSONE A,et al. therapy and cognition:international cognition and cancer
Comparison of effects of metformin,phenformin,and in‐ task force recommendations for harmonising preclinical
hibitors of mitochondrial complex Ⅰ on mitochondrial research[J]. Cancer Treat Rev,2018,69:72-83.
permeability transition and ischemic brain injury[J]. Bio‐ [38] SRITAWAN N,SUWANNAKOT K,NAEWLA S,et al.
molecules,2020,10(10):1400. Effect of metformin treatment on memory and hippocam‐
[30] HESTON M B,HANSLIK K L,ZARBOCK K R,et al. pal neurogenesis decline correlated with oxidative stress
Gut inflammation associated with age and Alzheimer’s induced by methotrexate in rats[J]. Biomed Pharmacother,
disease pathology:a human cohort study[J]. Sci Rep, 2021,144:112280.
2023,13(1):18924. [39] HASAN H F,RASHED L A,EL BAKARY N M. Con‐
[31] HUNG C C,CHANG C C,HUANG C W,et al. Gut mi‐ certed outcome of metformin and low dose of radiation in
crobiota in patients with Alzheimer’s disease spectrum:a modulation of cisplatin induced uremic encephalopathy
systematic review and meta-analysis[J]. Aging (Albany via renal and neural preservation[J]. Life Sci,2021,276:
NY),2022,14(1):477-496. 119429.
[32] MA X Y,XIAO W C,LI H,et al. Metformin restores hip‐ [40] 张唯聪,刘小倩,王瑛,等. 二甲双胍联合多奈哌齐治疗
pocampal neurogenesis and learning and memory via regu‐ 阿尔茨海默病的临床效果[J]. 中国当代医药,2023,30
lating gut microbiota in the obese mouse model[J]. Brain (8):11-15.
Behav Immun,2021,95:68-83. (收稿日期:2025-04-10 修回日期:2025-07-07)
[33] ZHU X Q,SHEN J Y,FENG S Y,et al. Akkermansia mu‐ (编辑:唐晓莲)
ciniphila,which is enriched in the gut microbiota by met‐
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