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参考文献 [13] HU T,WEI J W,ZHENG J Y,et al. Metformin improves
[ 1 ] 中国痴呆与认知障碍指南写作组,中国医师协会神经内 cognitive dysfunction through SIRT1/NLRP3 pathway-
科医师分会认知障碍疾病专业委员会 . 2018 中国痴呆 mediated neuroinflammation in db/db mice[J]. J Mol Med
与认知障碍诊治指南(一):痴呆及其分类诊断标准 [J]. (Berl),2024,102(9):1101-1115.
中华医学杂志,2018,98(13):965-70. [14] ZHANG W W,ZHAO L X,ZHANG J W,et al. Metfor‐
[ 2 ] 王刚,齐金蕾,刘馨雅,等. 中国阿尔茨海默病报告2024 min improves cognitive impairment in diabetic mice in‐
[J]. 诊断学理论与实践,2024,23(3):219-256. duced by a combination of streptozotocin and isoflurane
[ 3 ] BAILEY C J. Metformin:historical overview[J]. Diabeto‐ anesthesia[J]. Bioengineered,2021,12(2):10982-10993.
logia,2017,60(9):1566-1576. [15] TWAROWSKI B,HERBET M. Inflammatory processes
[ 4 ] CUI W X,LV C,GENG P L,et al. Novel targets and in Alzheimer’s disease-pathomechanism,diagnosis and
therapies of metformin in dementia:old drug,new insights treatment:a review[J]. Int J Mol Sci,2023,24(7):6518.
[J]. Front Pharmacol,2024,15:1415740. [16] MANDWIE M,KARUNIA J,NIAZ A,et al. Metformin
[ 5 ] LEE J E,YU S H,KIM S R,et al. Efficacy and safety of treatment attenuates brain inflammation and rescues
metformin and atorvastatin combination therapy vs. mono‐ PACAP/VIP neuropeptide alterations in mice fed a high-
therapy with either drug in type 2 diabetes mellitus and fat diet[J]. Int J Mol Sci,2021,22(24):13660.
dyslipidemia patients (ATOMIC):double-blinded ran‐ [17] WEI J T,QI H,LIU K K,et al. Effects of metformin on
domized controlled trial[J]. Diabetes Metab J,2024,48 life span,cognitive ability,and inflammatory response in
(4):730-739. a short-lived fish[J]. J Gerontol A Biol Sci Med Sci,2020,
[ 6 ] GALLEGO-RUDOLF J,WIESMAN A I,BINETTE A P, 75(11):2042-2050.
et al. Synergistic association of Aβ and tau pathology with [18] KODALI M,ATTALURI S,MADHU L N,et al. Metfor‐
cortical neurophysiology and cognitive decline in asymp‐ min treatment in late middle age improves cognitive func‐
tomatic older adults[J]. Nat Neurosci,2024,27(11):2130- tion with alleviation of microglial activation and enhance‐
2137. ment of autophagy in the hippocampus[J]. Aging Cell,
[ 7 ] CHEN Y X,ZHAO S,FAN Z Q,et al. Metformin attenu‐ 2021,20(2):e13277.
ates plaque-associated tau pathology and reduces amyloid- [19] XIANG J B,LU Y M,QUAN C,et al. Metformin protects
β burden in APP/PS1 mice[J]. Alzheimers Res Ther, radiation-induced early brain injury by reducing inflamma‐
2021,13(1):40. tion and DNA damage[J]. Brain Sci,2023,13(4):645.
[ 8 ] XU X Y,SUN Y Q,CEN X F,et al. Metformin activates [20] DIBONA V L,SHAH M K,KRAUSE K J,et al. Metfor‐
chaperone-mediated autophagy and improves disease pa‐ min reduces neuroinflammation and improves cognitive
thologies in an Alzheimer disease mouse model[J]. Protein functions after traumatic brain injury[J]. Neurosci Res,
Cell,2021,12(10):769-787. 2021,172:99-109.
[ 9 ] 栗西彤,关红,杨乐. 胰岛素抵抗与2型糖尿病认知功能障 [21] GRIFFITHS J,GRANT S G N. Synapse pathology in Al‐
碍的研究进展[J]. 中国老年学杂志,2023,43(1):239-242. zheimer’s disease[J]. Semin Cell Dev Biol,2023,139:
[10] KENAWY S,HEGAZY R,HASSAN A,et al. Involve‐ 13-23.
ment of insulin resistance in D-galactose-induced age- [22] FAN P,LU Y Y,WEI H D,et al. Metformin attenuates
related dementia in rats:protective role of metformin and sevoflurane-induced neurogenesis damage and cognitive
saxagliptin[J]. PLoS One,2017,12(8):e0183565. impairment:involvement of the Nrf2/G6PD pathway[J].
[11] LU X Y,HUANG S,CHEN Q B,et al. Metformin amelio‐ Metab Brain Dis,2023,38(6):2037-2053.
rates Aβ pathology by insulin-degrading enzyme in a [23] YANG Y H,LU X Y,LIU N,et al. Metformin decelerates
transgenic mouse model of Alzheimer’s disease[J]. Oxid aging clock in male monkeys[J]. Cell,2024,187(22):
Med Cell Longev,2020,2020:2315106. 6358-6378.e29.
[12] KAZKAYASI I,TELLI G,NEMUTLU E,et al. Intranasal [24] ISMAIL T R,YAP C G,NAIDU R,et al. Environmental
metformin treatment ameliorates cognitive functions via enrichment and the combined interventions of EE and met‐
insulin signaling pathway in ICV-STZ-induced mice formin enhance hippocampal neuron survival and
model of Alzheimer’s disease[J]. Life Sci,2022,299: hippocampal-dependent memory in type 2 diabetic rats un‐
120538. der stress through the BDNF-TrkB signaling pathways[J].
中国药房 2025年第36卷第15期 China Pharmacy 2025 Vol. 36 No. 15 · 1945 ·

