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参考文献                                               [13]  HU T,WEI J W,ZHENG J Y,et al. Metformin improves
          [ 1 ]  中国痴呆与认知障碍指南写作组,中国医师协会神经内                         cognitive  dysfunction  through  SIRT1/NLRP3  pathway-
              科医师分会认知障碍疾病专业委员会 . 2018 中国痴呆                        mediated neuroinflammation in db/db mice[J]. J Mol Med
              与认知障碍诊治指南(一):痴呆及其分类诊断标准 [J].                       (Berl),2024,102(9):1101-1115.
              中华医学杂志,2018,98(13):965-70.                     [14]  ZHANG W W,ZHAO L X,ZHANG J W,et al. Metfor‐
          [ 2 ]  王刚,齐金蕾,刘馨雅,等. 中国阿尔茨海默病报告2024                     min  improves  cognitive  impairment  in  diabetic  mice  in‐
              [J]. 诊断学理论与实践,2024,23(3):219-256.                   duced  by  a  combination  of  streptozotocin  and  isoflurane
          [ 3 ]  BAILEY C J. Metformin:historical overview[J]. Diabeto‐  anesthesia[J]. Bioengineered,2021,12(2):10982-10993.
              logia,2017,60(9):1566-1576.                    [15]  TWAROWSKI  B,HERBET  M.  Inflammatory  processes
          [ 4 ]  CUI  W  X,LV  C,GENG  P  L,et  al.  Novel  targets  and   in  Alzheimer’s  disease-pathomechanism,diagnosis  and
              therapies of metformin in dementia:old drug,new insights  treatment:a review[J]. Int J Mol Sci,2023,24(7):6518.
              [J]. Front Pharmacol,2024,15:1415740.          [16]  MANDWIE M,KARUNIA J,NIAZ A,et al. Metformin
          [ 5 ]  LEE J E,YU S H,KIM S R,et al. Efficacy and safety of   treatment  attenuates  brain  inflammation  and  rescues
              metformin and atorvastatin combination therapy vs. mono‐  PACAP/VIP neuropeptide alterations in mice fed a high-
              therapy  with  either  drug  in  type  2  diabetes  mellitus  and   fat diet[J]. Int J Mol Sci,2021,22(24):13660.
              dyslipidemia  patients (ATOMIC):double-blinded  ran‐  [17]  WEI J T,QI H,LIU K K,et al. Effects of metformin on
              domized  controlled  trial[J].  Diabetes  Metab  J,2024,48  life span,cognitive ability,and inflammatory response in
              (4):730-739.                                        a short-lived fish[J]. J Gerontol A Biol Sci Med Sci,2020,
          [ 6 ]  GALLEGO-RUDOLF J,WIESMAN A I,BINETTE A P,        75(11):2042-2050.
              et al. Synergistic association of Aβ and tau pathology with   [18]  KODALI M,ATTALURI S,MADHU L N,et al. Metfor‐
              cortical neurophysiology and cognitive decline in asymp‐  min treatment in late middle age improves cognitive func‐
              tomatic older adults[J]. Nat Neurosci,2024,27(11):2130-  tion with alleviation of microglial activation and enhance‐
              2137.                                               ment  of  autophagy  in  the  hippocampus[J].  Aging  Cell,
          [ 7 ]  CHEN Y X,ZHAO S,FAN Z Q,et al. Metformin attenu‐  2021,20(2):e13277.
              ates plaque-associated tau pathology and reduces amyloid-  [19]  XIANG J B,LU Y M,QUAN C,et al. Metformin protects
              β  burden  in  APP/PS1  mice[J].  Alzheimers  Res  Ther,  radiation-induced early brain injury by reducing inflamma‐
              2021,13(1):40.                                      tion and DNA damage[J]. Brain Sci,2023,13(4):645.
          [ 8 ]  XU X Y,SUN Y Q,CEN X F,et al. Metformin activates   [20]  DIBONA V L,SHAH M K,KRAUSE K J,et al. Metfor‐
              chaperone-mediated  autophagy  and  improves  disease  pa‐  min  reduces  neuroinflammation  and  improves  cognitive
              thologies in an Alzheimer disease mouse model[J]. Protein   functions  after  traumatic  brain  injury[J].  Neurosci  Res,
              Cell,2021,12(10):769-787.                           2021,172:99-109.
          [ 9 ]  栗西彤,关红,杨乐. 胰岛素抵抗与2型糖尿病认知功能障                 [21]  GRIFFITHS J,GRANT S G N. Synapse pathology in Al‐
              碍的研究进展[J]. 中国老年学杂志,2023,43(1):239-242.              zheimer’s  disease[J].  Semin  Cell  Dev  Biol,2023,139:
          [10]  KENAWY  S,HEGAZY  R,HASSAN A,et  al.  Involve‐    13-23.
              ment  of  insulin  resistance  in  D-galactose-induced  age-  [22]  FAN  P,LU Y Y,WEI  H  D,et  al.  Metformin  attenuates
              related dementia in rats:protective role of metformin and   sevoflurane-induced  neurogenesis  damage  and  cognitive
              saxagliptin[J]. PLoS One,2017,12(8):e0183565.       impairment:involvement  of  the  Nrf2/G6PD  pathway[J].
          [11]  LU X Y,HUANG S,CHEN Q B,et al. Metformin amelio‐  Metab Brain Dis,2023,38(6):2037-2053.
              rates  Aβ  pathology  by  insulin-degrading  enzyme  in  a   [23]  YANG Y H,LU X Y,LIU N,et al. Metformin decelerates
              transgenic mouse model of Alzheimer’s disease[J]. Oxid   aging  clock  in  male  monkeys[J].  Cell,2024,187(22):
              Med Cell Longev,2020,2020:2315106.                  6358-6378.e29.
          [12]  KAZKAYASI I,TELLI G,NEMUTLU E,et al. Intranasal   [24]  ISMAIL T R,YAP C G,NAIDU R,et al. Environmental
              metformin  treatment  ameliorates  cognitive  functions  via   enrichment and the combined interventions of EE and met‐
              insulin  signaling  pathway  in  ICV-STZ-induced  mice   formin  enhance  hippocampal  neuron  survival  and
              model  of  Alzheimer’s  disease[J].  Life  Sci,2022,299:  hippocampal-dependent memory in type 2 diabetic rats un‐
              120538.                                             der stress through the BDNF-TrkB signaling pathways[J].


          中国药房  2025年第36卷第15期                                              China Pharmacy  2025 Vol. 36  No. 15    · 1945 ·
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