Page 124 - 《中国药房》2024年14期

静脉用药复溶剂生成系统及溶媒配伍禁忌规则库的建立及应用
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黄 莺 ，李培芳，杜德才，方 明，刘 圣 [中国科学技术大学附属第一医院（安徽省立医院）药学部，合肥
#
230001]

中图分类号 R95 文献标志码 A 文章编号 1001-0408（2024）14-1786-04
DOI 10.6039/j.issn.1001-0408.2024.14.20

摘 要 目的 规范注射用无菌粉末复溶剂及静脉用药溶媒的使用，保障临床用药安全。 方法 我院审方药师团队通过制定需用
灭菌注射用水溶解的药品目录和静脉用药溶媒配伍禁忌表，在医院信息系统中搭建静脉用药复溶剂生成系统及静脉用药溶媒配
伍禁忌规则库。统计分析我院2023年1－4月（静脉用药溶媒配伍禁忌规则库实施前）和2023年5－8月（实施后）审核干预的不合
理医嘱，比较实施前后我院溶媒选择不合理医嘱数量、拦截率及药师对溶媒选择不合理医嘱干预成功率的变化情况。结果 我院
静脉用药溶媒配伍禁忌规则库实施前，共发现溶媒选择不合理医嘱5 229组，其中严重不合理医嘱有1 204组，拦截率为23.03%，
审方药师对其的干预成功率为15.90%；实施后，共发现溶媒选择不合理医嘱3 258组，其中严重不合理医嘱有1 148组，拦截率为
35.24%，药师对其的干预成功率为24.83%，均显著高于实施前（P＜0.01或P＜0.001）。结论 我院通过建立并应用静脉用药复溶
剂生成系统及静脉用药溶媒配伍禁忌规则库，显著提高了对溶媒选择不合理医嘱的拦截率和药师干预成功率，有助于保障患者用
药安全。
关键词 注射用无菌粉末；复溶剂；溶媒；配伍禁忌

Establishment and application of intravenous drug resolvent generation system and solvent incompatibility
rules library
HUANG Ying，LI Peifang，DU Decai，FANG Ming，LIU Sheng[Dept. of Pharmacy， the First Affiliated Hospital
of University of Science and Technology of China （Anhui Provincial Hospital）， Hefei 230001， China]

ABSTRACT OBJECTIVE To standardize the use of sterile powder for injection redissolution solvent and intravenous drugs
diluent solvent， and ensure the safety of clinical drug use. METHODS The intravenous drug resolvent generation system and the
intravenous drug solvent incompatibility rules library were constructed and operated by prescription-checking pharmacist team in our
hospital by formulating a list of intravenous drugs needed to be dissolved with sterilized water for injection and a contraindication
list of intravenous solvent compatibility. The unreasonable medical orders reviewed and intervened in our hospital from January to
April 2023 （before the implementation of the intravenous drug solvent incompatibility rules library） and from May to August 2023
（after the implementation） were analyzed statistically to compare the number of unreasonable solvent selection orders， interception
rate， and the success rate of pharmacists’ interventions for unreasonable solvent selection orders before and after the
implementation. RESULTS Before the implementation of the solvent incompatibility rules library， a total of 5 229 groups of
medical orders with unreasonable solvent selection in our hospital were identified， among which there were 1 204 groups of
seriously unreasonable medical orders， with interception rate of 23.03% and the success rate of pharmacists’ intervention of
15.90%. After the implementation of the solvent incompatibility rules library， the total number of medical orders with unreasonable
solvent selection was 3 258 groups， among which there were 1 148 groups of seriously unreasonable medical orders， with
interception rate of 35.24% and success rate of pharmacists’ intervention of 24.83%， being significantly higher than before
implementation （P＜0.01 or P＜0.001）. CONCLUSIONS The establishment and application of the intravenous drug resolvent
generation system and the solvent incompatibility rules library can significantly increase the interception rate of unreasonable solvent
selection orders and the success rate of pharmacists’ interventions, and ensure the safety of clinical drug use.
KEYWORDS sterile powder for injection； redissolution solvent； solvent； incompatibility

Δ 基金项目 安徽省教育厅高等学校省级质量工程项目（No. 静脉用药物通过静脉注射或静脉滴注等方式直接
2020jyxm2319） 进入血液循环，起效迅速，为临床预防、治疗和诊断疾病
＊第一作者 副主任药师，硕士。研究方向：医院药学、药理学、循
的常用剂型。为保证静脉用药物的稳定性，许多药物被
证医学。E-mail：79485443@qq.com
制成注射用无菌粉末，也称“粉针”，临用时用适宜的复
# 通信作者 主任中药师。研究方向：中药学。E-mail：lslcclhl@
163.com 溶剂充分溶解，再用溶媒进一步稀释成一定浓度的成品

· 1786 · China Pharmacy 2024 Vol. 35 No. 14 中国药房 2024年第35卷第14期