Page 83 - 《中国药房》2023年18期
P. 83

clinical trials[J]. Front Nutr,2023,10:1155306.     nonalcoholic steatohepatitis[J]. N Engl J Med,2021,384
          [14]  ZHANG  C  S,TENG  Y  L,LI  F  Q,et  al.  Nanoparticle-  (12):1113-1124.
              mediated RNA therapy attenuates nonalcoholic steatohepa‐  [25]  ARMSTRONG M J,GAUNT P,AITHAL G P,et al. Lira‐
              titis and related fibrosis by targeting activated hepatic stel‐  glutide safety and efficacy in patients with non-alcoholic
              late cells[J]. ACS Nano,2023,17(15):14852-14870.    steatohepatitis(LEAN):a multicentre,double-blind,ran‐
          [15]  段蓉,李正翔. 国内外药物警戒研究现状与热点的文献                         domised,placebo-controlled  phase  2  study[J].  Lancet,
              计量学分析[J]. 中国药房,2022,33(1):116-122.                  2016,387(10019):679-690.
          [16]  BANDYOPADHYAY  S,SAMAJDAR  S  S,DAS  S.         [26]  HARTMAN  M  L,SANYAL  A  J,LOOMBA  R,et  al.
              Effects  of  saroglitazar  in  the  treatment  of  non-alcoholic   Effects  of  novel  dual  GIP  and  GLP-1  receptor  agonist
              fatty  liver  disease  or  non-alcoholic  steatohepatitis:a      tirzepatide  on  biomarkers  of  nonalcoholic  steatohepatitis
              systematic review and meta-analysis[J]. Clin Res Hepatol   in patients with type 2 diabetes[J]. Diabetes Care,2020,43
              Gastroenterol,2023,47(7):102174.                   (6):1352-1355.
          [17]  GOYAL N P,MENCIN A,NEWTON K P,et al. An open   [27]  RIZZO M,COLLETTI A,PENSON P E,et al. Nutraceutical
              label,randomized,multicenter study of elafibranor in chil‐  approaches to non-alcoholic fatty liver disease(NAFLD):
              dren with nonalcoholic steatohepatitis[J]. J Pediatr Gastro‐  a position paper from the International Lipid Expert Panel
              enterol Nutr,2023,77(2):160-165.                   (ILEP)[J]. Pharmacol Res,2023,189:106679.
          [18]  FRANCQUE S M,BEDOSSA P,RATZIU V,et al. A ran‐  [28]  SANYAL  A,CHARLES  E  D,NEUSCHWANDER-
              domized,controlled trial of the pan-PPAR agonist lanifi‐  TETRI B A,et al. Pegbelfermin(BMS-986036),a PEGylated
              branor in NASH[J]. N Engl J Med,2021,385(17):1547-  fibroblast  growth  factor  21  analogue,in  patients  with
              1558.                                               non-alcoholic steatohepatitis:a randomised,double-blind,
          [19]  NAKAJIMA  A,EGUCHI  Y,YONEDA  M,et  al.  Ran‐     placebo-controlled,phase  2a  trial[J].  Lancet,2019,392
              domised  clinical  trial:pemafibrate,a  novel  selective       (10165):2705-2717.
              peroxisome  proliferator-activated  receptor  α  modulator  [29]  LI L M,SONG Y,SHI Y Q,et al. Thyroid hormone recep‐
              (SPPARMα),versus placebo in patients with no-nalcoholic   tor-β agonists in NAFLD therapy:possibilities and chal‐
              fatty  liver  disease[J]. Aliment  Pharmacol  Ther,2021,54  lenges[J]. J Clin Endocrinol Metab,2023,108(7):1602-
              (10):1263-1277.                                     1613.
          [20]  YOUNOSSI  Z  M,RATZIU  V,LOOMBA  R,et  al.   [30]  RATZIU V,SANYAL A,HARRISON S A,et al. Cenicri‐
              Obeticholic acid for the treatment of non-alcoholic steato‐  viroc  treatment  for  adults  with  nonalcoholic  steatohepatitis
              hepatitis:interim analysis from a multicentre,randomised,  and fibrosis:final analysis of the phase 2b centaur study
              placebo-controlled  phase  3  trial[J].  Lancet,2019,394  [J]. Hepatology,2020,72(3):892-905.
              (10215):2184-2196.                             [31]  XIE W T,SU F G,WANG G Z,et al. Glucose-lowering
          [21]  PATEL K,HARRISON S A,ELKHASHAB M,et al. Cilo‐     effect of berberine on type 2 diabetes:a systematic review
              fexor,a nonsteroidal FXR agonist,in patients with noncir‐  and meta-analysis[J]. Front Pharmacol,2022,13:1015045.
              rhotic  NASH:a  phase  2  randomized  controlled  trial[J].   [32]  JIANG  J  J,ZHANG  G  F,ZHENG  J Y,et  al. Targeting
              Hepatology,2020,72(1):58-71.                        mitochondrial  ROS-mediated  ferroptosis  by  quercetin
          [22]  RATZIU V,RINELLA M E,NEUSCHWANDER-TETRI           alleviates high-fat diet-induced hepatic lipotoxicity[J]. Front
              B A,et al. EDP-305 in patients with NASH:a phase Ⅱ   Pharmacol,2022,13:876550.
              double-blind  placebo-controlled  dose-ranging  study[J].  J   [33]  阮小风,张建军,杜鹏,等. 基于CiteSpace软件的非酒精
              Hepatol,2022,76(3):506-517.                         性脂肪性肝病治疗的可视化分析[J]. 华南国防医学杂
          [23]  李政,陈莲如,刘玉霞. 非酒精性脂肪肝病药物研究进展                        志,2019,33(12):815-822.
              [J]. 聊城大学学报(自然科学版),2023,36(2):68-78.                          (收稿日期:2023-05-04  修回日期:2023-08-28)
          [24]  NEWSOME  P  N,BUCHHOLTZ  K,CUSI  K,et  al.  A                                     (编辑:孙 冰)
              placebo-controlled  trial  of  subcutaneous  semaglutide  in
















          中国药房  2023年第34卷第18期                                              China Pharmacy  2023 Vol. 34  No. 18    · 2249 ·
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