Page 126 - 2021年18期
P. 126
to structure-activity relationship[J]. Toxicol In Vitro, 896.
2019,61:104642. [53] SANDEEP M S,SRIDHAR V,PUNEETH Y,et al. En-
[41] PARK J W,CHOI J S. Role of kaempferol to increase bio- hanced oral bioavailability of felodipine by naringenin in
availability and pharmacokinetics of nifedipine in rats[J]. Wistar rats and inhibition of P-glycoprotein in everted rat
Chin J Nat Med,2019,17(9):690-697. gut sacs in vitro[J]. Drug Dev Ind Pharm,2014,40(10):
[42] LI C,LI X,CHOI J S. Enhanced bioavailability of etopo- 1371-1377.
side after oral or intravenous administration of etoposide [54] MOTAWI T K,TELEB Z A,EL-BOGHDADY N A,et al.
with kaempferol in rats[J]. Arch Pharm Res,2009,32(1): Effect of simvastatin and naringenin coadministration on
133-138. rat liver DNA fragmentation and cytochrome P450 activity:
[43] PIAO Y,SHIN S C,CHOI J S. Effects of oral kaempferol an in vivo and in vitro study[J]. J Physiol Biochem,2014,
on the pharmacokinetics of tamoxifen and one of its me- 70(1):225-237.
tabolites,4-hydroxytamoxifen,after oral administration of [55] PINGILI R,VEMULAPALLI S,MULLAPUDI S S,et al.
tamoxifen to rats[J]. Biopharm Drug Dispos,2008,29(4): Pharmacokinetic interaction study between flavanones
245-249. (hesperetin,naringenin)and rasagiline mesylate in Wistar
[44] HA H R,CHEN J,LEUENBERGER P M,et al. In vitro rats[J]. Drug Dev Ind Pharm,2016,42(7):1110-1117.
inhibition of midazolam and quinidine metabolism by fla- [56] ZHANG F Y,DU G J,ZHANG L,et al. Naringenin en-
vonoids[J]. Eur J Clin Pharmacol,1995,48(5):367-371. hances the anti-tumor effect of doxorubicin through selec-
[45] PATEL J,BUDDHA B,DEY S,et al. In vitro interaction tively inhibiting the activity of multidrug resistance-asso-
of the HIV protease inhibitor ritonavir with herbal consti- ciated proteins but not P-glycoprotein[J]. Pharm Res,
tuents:changes in P-gp and CYP3A4 activity[J]. Am J 2009,26(4):914-925.
Ther,2004,11(4):262-277. [57] QIU J X,ZHOU Z W,HE Z X,et al. Estimation of the
[46] LIMTRAKUL P,KHANTAMAT O,PINTHA K. Inhibi- binding modes with important human cytochrome P450 en-
tion of P-glycoprotein function and expression by kaemp- zymes,drug interaction potential,pharmacokinetics,and
ferol and quercetin[J]. J Chemother,2005,17(1):86-95. hepatotoxicity of ginger components using molecular
[47] IMAI Y,TSUKAHARA S,ASADA S,et al. Phytoestro- docking,computational,and pharmacokinetic modeling
gens/flavonoids reverse breast cancer resistance protein/ studies[J]. Drug Des Devel Ther,2015,9:841-866.
ABCG2-mediated multidrug resistance[J]. Cancer Res, [58] MA Y L,ZHAO F,YIN J T,et al. Two approaches for
2004,64(12):4346-4352. evaluating the effects of galangin on the activities and
[48] MANDERY K,BUJOK K,SCHMIDT I,et al. Influence mRNA expression of seven CYP450[J]. Molecules,2019,24
of the flavonoids apigenin,kaempferol,and quercetin on (6):1171.
the function of organic anion transporting polypeptides [59] LOU D,BAO S S,LI Y H,et al. Inhibitory mechanisms of
1A2 and 2B1[J]. Biochem Pharmacol,2010,80(11): myricetin on human and rat liver cytochrome P450 en-
1746-1753. zymes[J]. Eur J Drug Metab Pharmacokinet,2019,44(5):
[49] FAN X,BAI J,HU M,et al. Drug interaction study of fla- 611-618.
vonoids toward OATP1B1 and their 3D structure activity [60] LI Y,NING J,WANG Y,et al. Drug interaction study of
relationship analysis for predicting hepatoprotective effects flavonoids toward CYP3A4 and their quantitative struc-
[J]. Toxicology,2020,437:152445. ture activity relationship(QSAR)analysis for predicting
[50] QUINTIERI L,PALATINI P,NASSI A,et al. Flavonoids potential effects[J]. Toxicol Lett,2018,294:27-36.
diosmetin and luteolin inhibit midazolam metabolism by [61] WEI Y,ZHOU S,HAO T,et al. Further enhanced dissolu-
human liver microsomes and recombinant CYP3A4 and tion and oral bioavailability of docetaxel by coamorphiza-
CYP3A5 enzymes[J]. Biochem Pharmacol,2008,75(6): tion with a natural P-gp inhibitor myricetin[J]. Eur J
1426-1437. Pharm Sci,2019,129:21-30.
[51] AN G,WANG X,MORRIS M E. Flavonoids are inhibi- [62] CHOI S J,SHIN S C,CHOI J S. Effects of myricetin on
tors of human organic anion transporter 1(OAT1)-media- the bioavailability of doxorubicin for oral drug delivery in
ted transport[J]. Drug Metab Dispos,2014,42(9):1357- rats:possible role of CYP3A4 and P-glycoprotein inhibi-
1366. tion by myricetin[J]. Arch Pharm Res,2011,34(2):309-
[52] LU W J,FERLITO V,XU C,et al. Enantiomers of narin- 315.
genin as pleiotropic,stereoselective inhibitors of cyto- [63] ZANDEN J V,MUL A D,WORTELBOER H M,et al. Re-
chrome P450 isoforms[J]. Chirality,2011,23(10):891- versal of in vitro cellular MRP1 and MRP2 mediated vin-
·2292 · China Pharmacy 2021 Vol. 32 No. 18 中国药房 2021年第32卷第18期