Page 127 - 2021年18期

cristine resistance by the flavonoid myricetin[J]. Biochem 2016，19（2）：188-197.
Pharmacol，2005，69（11）：1657-1665. [76] RRONIS M J. Effects of soy containing diet and isofla-
[64] YU C P，WU P P，HOU Y C，et al. Quercetin and rutin re- vones on cytochrome P450 enzyme expression and activi-
duced the bioavailability of cyclosporine from neoral，an ty[J]. Drug Metab Rev，2016，48（3）：331-341.
immunosuppressant，through activating P-glycoprotein [77] KOPEČNÁ-ZAPLETALOVÁ M，KRASULOVÁ K，
and CYP3A4[J]. J Agric Food Chem，2011，59（9）：4644- ANZENBACHER P，et al. Interaction of isoflavonoids
4648. with human liver microsomal cytochromes P450：inhibition
[65] MOHANA S，GANESAN M，PRASAD N R，et al. Flavo- of CYP enzyme activities[J]. Xenobiotica，2017，47（4）：
noids modulate multidrug resistance through wnt signa- 324-331.
ling in P-glycoprotein overexpressing cell lines[J]. BMC [78] MITRA P S，BASU N K，OWENS I S. Src supports UDP-
Cancer，2018，18（1）：1168. glucuronosyltransferase-2B7 detoxification of catechol
[66] KUHLMANN O，HOFMANN H S，MÜLLER S P，et al. estrogens associated with breast cancer[J]. Biochem Bio-
Pharmacokinetics of idarubicin in the isolated perfused rat phys Res Commun，2009，382（4）：651-656.
lung：effect of cinchonine and rutin[J]. Anticancer Drugs， [79] CAI S A，HOU N，ZHAO G J，et al. Nrf2 is a key regula-
2003，14（6）：411-416. tor on puerarin preventing cardiac fibrosis and upregula-
[67] NGUYEN H，ZHANG S，MORRIS M E.Effect of flavo- ting metabolic enzymes UGT1A1 in rats[J]. Front Pharma-
noids on MRP1-mediated transport in Panc-1 cells[J]. J col，2018，9：540.
Pharm Sci，2003，92（2）：250-257. [80] GUO J，WANG Q，ZHANG Y，et al. Functional daidzein
[68] WONG C C，BOTTING N P，ORFILA C，et al. Flavonoid enhances the anticancer effect of topotecan and reverses
conjugates interact with organic anion transporters BCRP-mediated drug resistance in breast cancer[J]. Phar-
（OATs）and attenuate cytotoxicity of adefovir mediated macol Res，2019，147：104387.
by organic anion transporter 1（OAT1/SLC22A6）[J]. [81] MAHER H M，ALZOMAN N Z，SHEHATA S M，et al.
Biochem Pharmacol，2011，81（7）：942-949. Comparative pharmacokinetic profiles of selected irrever-
[69] OGURA J，KOIZUMI T，SEGAWA M，et al. Querce- sible tyrosine kinase inhibitors，neratinib and pelitinib，
tin-3-rhamnoglucoside（rutin）stimulates transport of or- with apigenin in rat plasma by UPLC-MS/MS[J]. J Pharm
ganic anion compounds mediated by organic anion trans- Biomed Anal，2017，137：258-267.
porting polypeptide 2B1[J]. Biopharm Drug Dispos，2014， [82] ZHAN Y Y，LIANG B Q，GU E M，et al. Inhibitory effect
35（3）：173-182. of apigenin onpharmacokinetics of venlafaxine in vivo
[70] KIM S J，KIM S J，HONG M，et al. Investigation of selec- and in vitro[J]. Pharmacology，2015，96（3/4）：118-123.
tive inhibitory effects of glycyrol on human CYP 1A1 and [83] EUMKEB G，CHUKRATHOK S. Synergistic activity and
2C9[J]. Xenobiotica，2016，46（10）：857-861. mechanism of action of ceftazidime and apigenin combi-
[71] HE W，WU J J，NING J，et al. Inhibition of human cyto- nation against ceftazidime-resistant enterobacter cloa-
chrome P450 enzymes by licochalcone A，a naturally occur- cae[J]. Phytomedicine，2013，20（3/4）：262-269.
ring constituent of licorice[J]. Toxicol In Vitro，2015，29 [84] NAVARRO-NÚÑEZ L，LOZANO M L，PALOMO M，et
（7）：1569-1576. al. Apigenin inhibits platelet adhesion and thrombus for-
[72] WANG X，ZHANG H，CHEN L，et al. Liquorice，a unique mation and synergizes with aspirin in the suppression of
“guide drug”of traditional Chinese medicine：a review of the arachidonic acid pathway[J]. J Agric Food Chem，
its role in drug interactions[J]. J Ethnopharmacol，2013， 2008，56（9）：2970-2976.
150（3）：781-790. [85] 王笃军，王硕，严峰，等.欧前胡素和异欧前胡素对小鼠肝
[73] GUO B，FAN X R，FANG Z Z，et al. Deglycosylation of CYP450的影响[J].中成药，2017，39（1）：14-20.
liquiritin strongly enhances its inhibitory potential to- [86] 曹艳，钟玉环，原梅，等.欧前胡素和异欧前胡素对人和大
wards UDP-glucuronosyltransferase（UGT） isoforms[J]. 鼠肝微粒体细胞色素 P450酶活性的抑制作用[J].中国中
Phytother Res，2013，27（8）：1232-1236. 药杂志，2013，38（8）：1237-1241.
[74] HE Y，CI X，XIE Y，et al. Potential detoxification effect of [87] LIAO Z G，TANG T，GUAN X J，et al. Improvement of
active ingredients in liquorice by upregulating efflux trans- transmembrane transport mechanism study of imperatorin
porter[J]. Phytomedicine，2019，56：175-182. on P-glycoprotein-mediated drug transport[J]. Molecules，
[75] SATOH T，FUJISAWA H，NAKAMURA A，et al. Inhibito- 2016，21（12）：1606.
（收稿日期：2020-12-21 修回日期：2021-08-12）
ry effects of eight green tea catechins on cytochrome P450
1A2，2C9，2D6，and 3A4 activities[J]. J Pharm Pharm Sci， （编辑：胡晓霖）

中国药房 2021年第32卷第18期 China Pharmacy 2021 Vol. 32 No. 18 ·2293 ·