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[ 2 ]  中华医学会神经外科学分会神经创伤专业组,中华医学                          杂志,2022,24(8):404-409.
               会创伤学分会颅脑创伤专业组. 颅脑创伤后癫痫防治中                      [14]  NORISUE Y,FUJIMOTO Y,NAKAGAWA  K.  Prelimi‐
               国 专 家 共 识 [J].  中 华 神 经 外 科 杂 志 ,2017,33(7):        nary  guideline-  and  pathophysiology-based  protocols  for
               652-654.                                            neurocritical care[J]. J Intensive Care,2018,6:45.
          [ 3 ]  NANAU  R  M,NEUMAN  M  G. Adverse  drug  reactions   [15]  DANESHVAR A,MOUSA  G.  Regression  shrinkage  and
               induced by valproic acid[J]. Clin Biochem,2013,46(15):  selection via least quantile shrinkage and selection opera‐
               1323-1338.                                          tor[J]. PLoS One,2023,18(2):e0266267.
          [ 4 ]  BADDOUR E,TEWKSBURY A,STAUNER N. Valproic    [16]  MOEDAS  M  F,SIMÕES  R  J  M,SILVA  M  F  B.  Mito‐
               acid-induced hyperammonemia:incidence,clinical signifi‐  chondrial  targets  in  hyperammonemia:addressing  urea
               cance,and  treatment  management[J].  Ment  Health  Clin,  cycle  function  to  improve  drug  therapies[J].  Biochem
               2018,8(2):73-77.                                    Pharmacol,2024,222:116034.
          [ 5 ]  WU  J  H,LI  J  Y,JING  W,et  al.  Valproic  acid-induced      [17]  BAI C,WANG H,DONG D,et al. Urea as a by-product
               encephalopathy:a review of clinical features,risk factors,  of  ammonia  metabolism  can  be  a  potential  serum  bio‐
               diagnosis,and  treatment[J].  Epilepsy  Behav,2021,120:  marker  of  hepatocellular  carcinoma[J].  Front  Cell  Dev
               107967.                                             Biol,2021,9:650748.
          [ 6 ]  MADHUVILAKKU R,HONG Y. Portable sensing probe   [18]  HUANG T K,SU Y C,SHIH C S. Valproic acid-induced
               for real-time quantification of ammonia in blood samples  hyperammonemia with encephalopathy in adults:a meta-
               [J].  ACS  Appl  Mater  Interfaces,2024,16(36):47242-  analysis[J].  Int  J  Clin  Pharmacol  Ther,2025,63(3):
               47256.                                              105-113.
          [ 7 ]  SHIBUE K. Artificial intelligence and machine learning in   [19]  DE FAZIO C,GOFFIN M,FRANCHI F,et al. Hyperam‐
               clinical medicine[J]. N Engl J Med,2023,388(25):2398.  monemia  during  treatment  with  valproate  in  critically  ill
          [ 8 ]  奚丽婧,郭昭艳,杨雪珂,等. LASSO及其拓展方法在回                      patients[J]. Clin Neurol Neurosurg,2022,212:107092.
               归分析变量筛选中的应用[J]. 中华预防医学杂志,2023,                 [20]  MARQUETAND  J,FREISINGER  P,LINDIG  T,et  al.
               57(1):107-111.                                      Ammonia  and  coma:a  case  report  of  late  onset  hemizy‐
          [ 9 ]  中华医学会神经病学分会,中华医学会神经病学分会脑                          gous ornithine carbamyltransferase deficiency in 68-year-
               电图与癫痫学组. 中国成人惊厥性癫痫持续状态诊治指                           old female[J]. BMC Neurol,2020,20(1):118.
               南:2025 版[J]. 中华神经科杂志,2025,58(12):1250-         [21]  中国医师协会医学遗传医师分会临床生化专业委员会,
               1258.                                               中华医学会儿科学分会内分泌遗传代谢学组,中国妇幼
          [10]  中国药理学会治疗药物监测研究专业委员会,中国医师                           保健协会儿童疾病和保健分会遗传代谢学组,等. 中国
               协会精神科医师分会,中国药理学会药源性疾病学委员                            尿素循环障碍诊断治疗和管理指南[J]. 中华儿科杂志,
               会,等 . 中国精神科治疗药物监测临床应用专家共识:                          2022,60(11):1118-1126.
               2022 年 版 [J].  神 经 疾 病 与 精 神 卫 生 ,2022,22(8):  [22]  ZHOU J,LYU L,ZHU L,et al. Association of overweight
               601-608.                                            with  postoperative  acute  kidney  injury  among  patients
          [11]  CHEN Y Q,CHEN J Z,ZHUANG X R,et al. Risk factors   receiving orthotopic liver transplantation:an observational
               of  elevated  blood  ammonia  level  in  epilepsy  patients   cohort study[J]. BMC Nephrol,2020,21(1):223.
               treated  with  lamotrigine[J].  Medicine,2022,101(26):  [23]  TSENG Y L,HUANG C R,LIN C H,et al. Risk factors
               e29780.                                             of  hyperammonemia  in  patients  with  epilepsy  under  val‐
          [12]  WOO P Y M,WOO A W Y,LAM S W,et al. Incidence,      proic acid therapy[J]. Medicine,2014,93(11):e66.
               presentation,and  risk  factors  for  sodium  valproate-  [24]  KWACK D W,KIM D W. Risk factors of hyperammone‐
               associated  hyperammonemia  in  neurosurgical  patients:a   mia in epilepsy patients with valproic acid therapy[J]. Clin
               prospective,observational  study[J].  World  Neurosurg,  Neurol Neurosurg,2023,233:107962.
               2020,144:e597-e604.                                          (收稿日期:2025-11-11  修回日期:2026-03-26)
          [13]  刘琛,赵浩,王宁,等. 神经外科围手术期患者应用丙戊                                                        (编辑:张元媛)
               酸钠预防癫痫的有效性和安全性分析[J]. 药物不良反应






          · 1044 ·    China Pharmacy  2026 Vol. 37  No. 8                              中国药房  2026年第37卷第8期
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