Page 130 - 《中国药房》2025年17期
P. 130

[19]  TVEIT K M,GUREN T,GLIMELIUS B,et al. Phase Ⅲ       as first-line chemotherapy in metastatic colorectal cancer
               trial of cetuximab with continuous or intermittent fluorou-   [J]. Clin Cancer Res,2019,25(10):2988-2995.
               racil,leucovorin,and  oxaliplatin(Nordic  FLOX)  versus   [29]  QIN S K,LI J,WANG L W,et al. Efficacy and tolerabi-
               FLOX alone in first-line treatment of metastatic colorectal   lity  of  first-line  cetuximab  plus  leucovorin,fluorouracil,
               cancer:the NORDIC-Ⅶ study[J]. J Clin Oncol,2012,30  and  oxaliplatin(FOLFOX-4)  versus  FOLFOX-4  in  pa‐
              (15):1755-1762.                                      tients  with  RAS  wild-type  metastatic  colorectal  cancer:
          [20]  VAN  CUTSEM  E,KÖHNE  C  H,LÁNG  I,et  al.  Cetu-   the  open-label,randomized,phase  Ⅲ TAILOR  trial[J].  J
               ximab plus irinotecan,fluorouracil,and leucovorin as first-  Clin Oncol,2018,36(30):3031-3039.
               line  treatment  for  metastatic  colorectal  cancer:updated   [30]  ROSSINI  D,ANTONIOTTI  C,LONARDI  S,et  al.  Up‐
               analysis of overall survival according to tumor KRAS and   front  modified  fluorouracil,leucovorin,oxaliplatin,and
               BRAF  mutation  status[J].  J  Clin  Oncol,2011,29(15):  irinotecan plus panitumumab versus fluorouracil,leucovo‐
               2011-2019.                                          rin,and  oxaliplatin  plus  panitumumab  for  patients  with
          [21]  ANTONIOTTI C,BORELLI B,ROSSINI D,et al. Atezo‐     RAS/BRAF  wild-type  metastatic  colorectal  cancer:the
               TRIBE:a randomised phase Ⅱ study of FOLFOXIRI plus   phase  Ⅲ  TRIPLETE  study  by  GONO[J].  J  Clin  Oncol,
               bevacizumab  alone  or  in  combination  with  atezolizumab   2022,40(25):2878-2888.
               as initial therapy for patients with unresectable metastatic   [31]  SCHMOLL  H  J,MANN  J,MEINERT  F,et  al.  Efficacy
               colorectal cancer[J]. BMC Cancer,2020,20(1):683.    and quality of life for FOLFOX/bevacizumab +/- irinote‐
          [22]  ARANDA E,VIÉITEZ J M,GÓMEZ-ESPAÑA A,et al.         can  in  first-line  metastatic  colorectal  cancer-final  results
               FOLFOXIRI plus bevacizumab versus FOLFOX plus be‐   of the AIO CHARTA trial[J]. Br J Cancer,2024,130(2):
               vacizumab  for  patients  with  metastatic  colorectal  cancer   233-241.
               and ≥3 circulating tumour cells:the randomised phase Ⅲ   [32]  SHIOZAWA  M,SUNAKAWA Y,WATANABE  T,et  al.
               VISNÚ-1 trial[J]. ESMO Open,2020,5(6):e000944.      Modified  FOLFOXIRI  plus  cetuximab  versus  bevaci‐
          [23]  HEINEMANN V,VON WEIKERSTHAL L F,DECKER             zumab  in  RAS  wild-type  metastatic  colorectal  cancer:a
               T,et al. FOLFIRI plus cetuximab or bevacizumab for ad‐  randomized  phase  Ⅱ  DEEPER  trial[J].  Nat  Commun,
               vanced  colorectal  cancer:final  survival  and  per-protocol   2024,15(1):10217.
               analysis  of  FIRE-3,a  randomised  clinical  trial[J].  Br  J   [33]  STINTZING  S,HEINRICH  K,TOUGERON  D,et  al.
               Cancer,2021,124(3):587-594.                         FOLFOXIRI plus cetuximab or bevacizumab as first-line
          [24]  LENZ  H  J,PARIKH  A,SPIGEL  D  R,et  al.  Modified   treatment of BRAF(V600E)-mutant metastatic colorectal
               FOLFOX6 plus bevacizumab with and without nivolumab   cancer:the randomized phase Ⅱ FIRE-4.5(AIO KRK0116)
               for  first-line  treatment  of  metastatic  colorectal  cancer:  study[J]. J Clin Oncol,2023,41(25):4143-4153.
               phase 2 results from the CheckMate 9X8 randomized clini-   [34]  TANG W T,REN  L,LIU T  S,et  al.  Bevacizumab  plus
               cal trial[J]. J Immunother Cancer,2024,12(3):e008409.  mFOLFOX6 versus mFOLFOX6 alone as first-line treat‐
          [25]  MAIELLO E,DI MAGGIO G,CORDIO S,et al. Bevaci‐      ment for RAS mutant unresectable colorectal liver-limited
               zumab in combination with either FOLFOX-4 or XELOX-  metastases:the BECOME randomized controlled trial[J]. J
               2 in first-line treatment of patients with metastatic colorec‐  Clin Oncol,2020,38(27):3175-3184.
               tal cancer:a multicenter randomized phase Ⅱ trial of the   [35]  LU H J,LIN J K,CHEN W S,et al. Primary tumor loca‐
               Gruppo Oncologico dell’Italia Meridionale(GOIM 2802)  tion is an important predictive factor for wild-type KRAS
               [J]. Clin Colorectal Cancer,2020,19(2):109-115.     metastatic  colon  cancer  treated  with  cetuximab  as  front-
          [26]  MODEST D P,MARTENS U M,RIERA-KNORRENSCHILD         line bio-therapy[J]. Asia Pac J Clin Oncol,2016,12(3):
               J,et al. FOLFOXIRI plus panitumumab as first-line treat‐  207-215.
               ment  of  RAS  wild-type  metastatic  colorectal  cancer:the   [36]  THIBAUDIN  M,FUMET  J  D,CHIBAUDEL  B,et  al.
               randomized,open-label,phase  Ⅱ  VOLFI  study(AIO    First-line  durvalumab  and  tremelimumab  with  chemo‐
               KRK0109)[J]. J Clin Oncol,2019,37(35):3401-3411.    therapy  in  RAS-mutated  metastatic  colorectal  cancer:a
          [27]  OKI E,EMI Y,YAMANAKA T,et al. Randomised phase     phase 1b/2 trial[J]. Nat Med,2023,29(8):2087-2098.
               Ⅱ  trial  of  mFOLFOX6  plus  bevacizumab  versus   [37]  DEPAUW  L,TOWNSEND  A,KARAPETIS  C,et  al.
               mFOLFOX6  plus  cetuximab  as  first-line  treatment  for   Role  of  locoregional  therapy  including  liver  transplanta‐
               colorectal liver metastasis(ATOM trial)[J]. Br J Cancer,  tion in liver-only metastatic colorectal cancer:a review pa‐
               2019,121(3):222-229.                                per[J]. Expert Rev Anticancer Ther,2025,25(1):41-53.
          [28]  PARIKH A  R,LEE  F  C,YAU  L,et  al.  MAVERICC,a            (收稿日期:2025-03-14  修回日期:2025-07-30)
               randomized,biomarker-stratified,phase  Ⅱ  study  of                                (编辑:刘明伟)
               mFOLFOX6-bevacizumab  versus  FOLFIRI-bevacizumab



          · 2204 ·    China Pharmacy  2025 Vol. 36  No. 17                            中国药房  2025年第36卷第17期
   125   126   127   128   129   130   131   132   133   134   135