Page 47 - 《中国药房》2025年15期

eling the role of fusion and fission processes[J]. Int J Mol CJFQ.
Sci，2023，24（17）：13033. [14] 卓桂锋，陈炜，张金枝，等. 益肺宣肺降浊方抗血管性痴
[ 4 ] RUIZ K，THAKER T M，AGNEW C，et al. Functional 呆的作用机制研究[J]. 中国药房，2024，35（18）：2207-
role of PGAM5 multimeric assemblies and their polymeri- 2212.
zation into filaments[J]. Nat Commun，2019，10（1）：531. [15] HAN B，JIANG W，LIU H J，et al. Upregulation of neuro‐
[ 5 ] KHANDIA R，MUNJAL A K，IQBAL H M N，et al. Heat nal PGC-1α ameliorates cognitive impairment induced by
shock proteins：therapeutic perspectives in inflammatory chronic cerebral hypoperfusion[J]. Theranostics，2020，10
disorders[J]. Recent Pat Inflamm Allergy Drug Discov， （6）：2832-2848.
2017，10（2）：94-104. [16] ZUO W，YAN F，LIU Z Y，et al. miR-330 regulates Drp1
[ 6 ] JACOBSEN A V，LOWES K N，TANZER M C，et al. mediated mitophagy by targeting PGAM5 in a rat model
HSP90 activity is required for MLKL oligomerisation and of permanent focal cerebral ischemia[J]. Eur J Pharmacol，
membrane translocation and the induction of necroptotic 2020，880：173143.
cell death[J]. Cell Death Dis，2016，7（1）：e2051. [17] HUANG G J，CONG Z L，WANG X Y，et al. Targeting
[ 7 ] YANG C K，HE S D. Heat shock protein 90 regulates HSP90 attenuates angiotensin Ⅱ -induced adventitial re‐
necroptosis by modulating multiple signaling effectors[J]. modelling via suppression of mitochondrial fission[J]. Car‐
Cell Death Dis，2016，7（3）：e2126. diovasc Res，2020，116（5）：1071-1084.
[ 8 ] LU W，SUN J H，YOON J S，et al. Mitochondrial protein [18] THIRSTRUP K，SOTTY F，MONTEZINHO L C P，et al.
PGAM5 regulates mitophagic protection against cell Linking HSP90 target occupancy to HSP70 induction and
necroptosis[J]. PLoS One，2016，11（1）：e0147792. efficacy in mouse brain[J]. Pharmacol Res，2016，104：
[ 9 ] KANG J S，CHO N J，LEE S W，et al. RIPK3 causes mito‐ 197-205.
chondrial dysfunction and albuminuria in diabetic podocy‐ [19] ZHAO X M，CHEN Z，ZHAO J B，et al. HSP90 modu‐
topathy through PGAM5-Drp1 signaling[J]. Metabolism， lates the stability of MLKL and is required for TNF-
2024，159：155982. induced necroptosis[J]. Cell Death Dis，2016，7（2）：e2089.
[10] WU L，ZHAO Q S，LI T W，et al. Yifei xuanfei jiangzhuo [20] DU Y，HE J Q，XU Y N，et al. SIRT6 prevent chronic cere‐
formula，a Chinese herbal decoction，improves memory bral hypoperfusion induced cognitive impairment by re‐
impairment through inhibiting apoptosis and enhancing modeling mitochondrial dynamics in a STAT5-PGAM5-
PKA/CREB signal transduction in rats with cerebral ische- Drp1 dependent manner[J]. J Transl Med，2024，22
mia/reperfusion[J]. Mol Med Rep，2015，12（3）：4273- （1）：788.
4283. [21] 沈海珊，王数，冯巩. 动力蛋白相关蛋白1（Drp1）在非酒
[11] ZHAI K F，DUAN H，WANG W，et al. Ginsenoside Rg1 精性脂肪性肝病中的作用[J]. 临床肝胆病杂志，2025，41
ameliorates blood-brain barrier disruption and traumatic （1）：159-163.
brain injury via attenuating macrophages derived exo‐ [22] ZHOU Y，SHE R N，MEI Z G，et al. Crosstalk between
somes miR-21 release[J]. Acta Pharm Sin B，2021，11 ferroptosis and necroptosis in cerebral ischemia/reperfu‐
（11）：3493-3507. sion injury and Naotaifang formula exerts neuroprotective
[12] 雷裕君，吴鹏，黄立武，等. 益肺宣肺降浊方对血管性痴 effect via HSP90-GCN2-ATF4 pathway[J]. Phytomedi‐
呆大鼠VEGF基因表达及线粒体凋亡通路的影响[J]. 广 cine，2024，130：155399.
西中医药，2020，43（1）：60-62. [23] SAITA S，ISHIHARA T，MAEDA M，et al. Distinct types
[13] 黄德庆，任昕怡，陈炜，等 . 益肺宣肺降浊方调控 miR- of protease systems are involved in homeostasis regula‐
485/AIM2 炎症小体途径治疗血管性痴呆的机制研究 tion of mitochondrial morphology via balanced fusion and
[J/OL]. 海南医学院学报，2024：1-16（2024-10-17）[2025- fission[J]. Genes Cells，2016，21（5）：408-424.
03-12]. http：//kns.cnki.net/KCMS/detail/detail.aspx?file‐ （收稿日期：2025-03-22 修回日期：2025-07-04）
name=HNYY20241016002&dbname=CJFD&dbcode= （编辑：舒安琴）

中国药房 2025年第36卷第15期 China Pharmacy 2025 Vol. 36 No. 15 · 1865 ·