Page 134 - 《中国药房》2025年12期

fect of varicocele treatment on fertility in adults：a syste- nucleus pulposus cells from oxidative stress-induced mito‐
matic review and meta-analysis of published prospective chondrial impairment through PDK-1[J]. Free Radic Biol
trials[J]. Eur Urol Focus，2023，9（1）：154-161. Med，2024，224：39-49.
[ 3 ] RAZI M，TAVALAEE M，SARRAFZADEH-REZAEI F， [16] ATA-ABADI N S，MOWLA S J，ABOUTALEBI F，et al.
et al. Varicocoele and oxidative stress：new perspectives Hypoxia-related long noncoding RNAs are associated
from animal and human studies[J]. Andrology，2021，9 with varicocele-related male infertility[J]. PLoS One，
（2）：546-558. 2020，15（4）：e0232357.
[ 4 ] WANG K X，GAO Y Y，WANG C，et al. Role of oxida‐ [17] MORETTI E，CERRETANI D，NOTO D，et al. Relation‐
tive stress in varicocele[J]. Front Genet，2022，13：850114. ship between semen IL-6，IL-33 and malondialdehyde
[ 5 ] MINHAS S，BOERI L，CAPOGROSSO P，et al. European generation in human seminal plasma and spermatozoa[J].
Association of Urology guidelines on male sexual and Reprod Sci，2021，28（8）：2136-2143.
reproductive health：2025 update on male infertility[J]. [18] MOAZAMIAN R，POLHEMUS A，CONNAUGHTON
Eur Urol，2025，87（5）：601-616. H，et al. Oxidative stress and human spermatozoa：diag‐
[ 6 ] 张婷，崔云，叶有骏，等. 补肾活血法治疗精索静脉曲张 nostic and functional significance of aldehydes generated
性不育研究概况[J]. 江西中医药，2024，55（2）：81-84，88. as a result of lipid peroxidation[J]. Mol Hum Reprod，
[ 7 ] DUN R L，YAO M，YANG L，et al. Traditional Chinese 2015，21（6）：502-515.
herb combined with surgery versus surgery for varicocele [19] NOWICKA-BAUER K，LEPCZYNSKI A，OZGO M，et
infertility：a systematic review and meta-analysis[J]. Evid al. Sperm mitochondrial dysfunction and oxidative stress
Based Complement Alternat Med，2015，2015：689056. as possible reasons for isolated asthenozoospermia[J]. J
[ 8 ] YU C，XIAO J H. The Keap1-Nrf2 system：a mediator be‐ Physiol Pharmacol，2018，69（3）：403-417.
tween oxidative stress and aging[J]. Oxid Med Cell Lon‐ [20] KURIBAYASHI S，FUKUHARA S，KITAKAZE H，et al.
gev，2021，2021：6635460. KEAP1-NRF2 system regulates age-related spermatoge-
[ 9 ] SHAHAT A M，RIZZOTO G，KASTELIC J P. Ameliora‐ nesis dysfunction[J]. Reprod Med Biol，2024，23（1）：
tion of heat stress-induced damage to testes and sperm e12595.
quality[J]. Theriogenology，2020，158：84-96. [21] XUE R，DU M，ZHOU T Y，et al. Polysaccharides from
[10] 耿强，郭军，王福，等. 加味天雄散对弱精子症患者精子 hemp seed protect against cyclophosphamide-induced in‐
p38 MAPK/ERK信号通路的影响[J]. 中国中医基础医学 testinal oxidative damage via Nrf2-Keap1 signaling path‐
杂志，2016，22（6）：788-791. way in mice[J]. Oxid Med Cell Longev，2020，2020：
[11] ZHAO G F，WANG Y，LAI Z Y，et al. Echinacoside pro‐ 1813798.
tects against dysfunction of spermatogenesis through the [22] VALIPOUR J，TAGHIZADEH F，ESFAHANI R，et al.
MAPK signaling pathway[J]. Reprod Sci，2022，29（5）： Role of nuclear factor erythroid 2-related factor 2（Nrf2）in
1586-1596. female and male fertility[J]. Heliyon，2024，10（9）：
[12] 郑军状 . 基于 ROS-线粒体信号-JNK/p38 MAPK 探讨 e29752.
“肝肾同源”及通精灵调控精索静脉曲张大鼠生精细胞 [23] 蒋越，蒙帅杰，王权胜，等 . 基于 Nrf2/HO-1 通路的加味
凋亡的机制[D]. 杭州：浙江中医药大学，2017. 大黄䗪虫颗粒对精索静脉曲张模型大鼠附睾生精细胞
[13] WANG R P，QIAO X Y，WANG X B. Exploring the 凋亡的影响[J]. 中华男科学杂志，2021，27（3）：240-248.
mechanisms of Gui zhi fu ling wan on varicocele via net‐ [24] KALTSAS A. Oxidative stress and male infertility：the
work pharmacology and molecular docking[J]. Androlo‐ protective role of antioxidants[J]. Medicina（Kaunas），
gia，2022，54（11）：e14635. 2023，59（10）：1769.
[14] GOREN M R，KILINC F，KAYASELCUK F，et al. Ef‐ [25] ELAHI M，HOJATI V，HASHEMITABAR M，et al. Nega‐
fects of experimental left varicocele repair on hypoxia- tive effect of varicocele on sperm mitochondrial dysfunc‐
inducible factor-1α and vascular endothelial growth factor tion：a cross-sectional study[J]. Int J Reprod Biomed，
expressions and angiogenesis in rat testis[J/OL]. Androlo‐ 2023，21（4）：323-332.
gia，2017，49（2）[2024-11-30]. http：//doi. org/10.1111/ [26] ZHU S M，LI W，YANG X，et al. Effects of autophagy on
and.12614. the spermatogonia of chronic hypoxic mice[J]. Am J
[15] LIU Z C，ZHENG J C，DING T，et al. HIF-1α protects Transl Res，2018，10（12）：4119-4129.

· 1540 · China Pharmacy 2025 Vol. 36 No. 12 中国药房 2025年第36卷第12期