Page 80 - 《中国药房》2025年8期

雌二醇片/雌二醇地屈孕酮片联合丹莪妇康煎膏对子宫内膜基底

层损伤高风险患者人工流产术后相关指标的影响
Δ

符 菲 ，韩 毓，韦先梅（海口市第四人民医院妇产科，海口 571100）
＊

中图分类号 R984；R715.2 文献标志码 A 文章编号 1001-0408（2025）08-0966-04
DOI 10.6039/j.issn.1001-0408.2025.08.13

摘 要 目的 探讨雌二醇片/雌二醇地屈孕酮片联合丹莪妇康煎膏对子宫内膜基底层损伤高风险患者人工流产术后恢复、性激
素、子宫动脉血流和子宫内膜的影响，并评价用药安全性。方法 回顾性收集2022年1月至2023年12月于我院行人工流产术的
244例子宫内膜基底层损伤高风险患者的临床资料，根据术后用药方案不同分为对照组（120例）和观察组（124例）。所有患者于
人工流产术后接受抗感染治疗。在此基础上，对照组患者给予雌二醇片/雌二醇地屈孕酮片，观察组患者给予雌二醇片/雌二醇地
屈孕酮片+丹莪妇康煎膏，两组均连续用药28 d。观察两组患者的阴道持续出血时间、腹痛持续时间、月经复潮时间及阴道出血
量，比较两组患者治疗前后的血清性激素水平[血清促卵泡生成素（FSH）、促黄体生成素（LH）、雌二醇和孕酮]、子宫动脉血流指标
[动脉收缩期峰值血流速度（PSV）、搏动指数（PI）和阻力指数（RI）]和子宫内膜厚度，记录患者的并发症和不良反应发生情况。结果
治疗后，观察组患者的阴道持续出血时间、阴道出血量、腹痛持续时间以及月经复潮时间均显著短于或少于对照组（P＜0.05）。治
疗后，两组患者的宫内膜厚度和血清 FSH、LH 水平以及 PSV 均显著厚于/高于同组治疗前，且观察组显著厚于/高于对照组（P＜
0.05）；雌二醇、孕酮水平和PI、RI均显著低于同组治疗前，且观察组显著低于对照组（P＜0.05）。观察组患者的并发症总发生率显
著低于对照组（P＜0.05）；两组患者的不良反应总发生率比较，差异无统计学意义（P＞0.05）。结论 雌二醇片/雌二醇地屈孕酮片
联合丹莪妇康煎膏可加速子宫内膜基底层损伤高风险患者人工流产术后的康复，促进子宫内膜增长，调节血清性激素水平，改善
子宫动脉血流，减少术后并发症的发生，且安全性较好。
关键词 雌二醇片；雌二醇地屈孕酮片；丹莪妇康煎膏；人工流产术；性激素；子宫动脉血流；子宫内膜

Effects of Estradiol tablet/Estradiol and dydrogesterone tablet combined with Dan’e fukang decoction on
postoperative indicators in patients with high risk of endometrial basal layer injury after induced abortion
FU Fei，HAN Yu，WEI Xianmei（Dept. of Gynaecology and Obstetrics， the Fourth People’s Hospital of Haikou，
Haikou 571100， China）

ABSTRACT OBJECTIVE To investigate the effects of Estradiol tablet/Estradiol and dydrogesterone tablet combined with Dan’e
fukang decoction on postoperative recovery， sex hormone levels， uterine artery blood flow， and endometrium in patients with high
risk of endometrial basal layer injury after induced abortion， and evaluate the safety of drug use. METHODS A retrospective
analysis was conducted on the clinical data of 244 patients with high risk of endometrial basal layer injury who underwent artificial
abortions in our hospital between January 2022 and December 2023. They were divided into control group （120 cases） and
observation group （124 cases） according to postoperative medication plan. All patients received anti-infective treatment after
induced abortion. Based on it， control group was given Estradiol tablet/Estradiol and dydrogesterone tablet， and observation group
was given Estradiol tablet/Estradiol and dydrogesterone tablet+Dan’e fukang decoction， for consecutive 28 d. The time of vaginal
bleeding， abdominal pain， return of menstruation， and vaginal bleeding volume were observed in 2 groups； serum sex hormone
levels [serum follicle stimulating hormone （FSH）， luteinizing hormone （LH）， estradiol， and progesterone]， uterine artery blood
flow parameters [peak systolic blood flow velocity （PSV）， pulsatility index （PI）， and resistance index （RI）] and endometrial
thickness were compared between the two groups before and after treatment. The occurrence of complications and adverse reactions
in patients were recorded. RESULTS After treatment， the duration of vaginal bleeding， vaginal bleeding volume， duration of
abdominal pain， and menstrual cycle recovery time in observation group were significantly shorter or less than the control group
（P＜0.05）. After treatment， both groups exhibited a significant increase in endometrial thickness， serum FSH and LH levels， and
PSV， compared to before treatment， and the observation group was significantly thicker/higher than the control group （P＜0.05）；
the levels of estradiol and progesterone， as well as the values of PI and RI， were significantly lower than those before treatment，
and the observation group was significantly lower than the control group （P＜0.05）. The total incidence of postoperative
complications in observation group was significantly lower
Δ 基金项目 海南省自然科学基金项目（No.123MS032）
＊第一作者 主治医师。研究方向：妇产科。E-mail：18789243573@ than control group （P＜0.05）， but there was no significant
163.com difference in the total incidence of adverse reactions between

· 966 · China Pharmacy 2025 Vol. 36 No. 8 中国药房 2025年第36卷第8期