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维奈克拉联合高三尖杉酯碱和阿糖胞苷治疗急性髓系白血病的

临床观察
Δ

周 玲 ，彭秋媛，赵 攀，魏 锦，林晓静，邹兴立，罗文丰，王 静，谢坤莹，李向龙，刘 洋，倪 勋（川北医学
#
＊
院附属医院血液科，四川 南充 637000）

中图分类号 R979.1；R733.71 文献标志码 A 文章编号 1001-0408（2024）14-1743-05
DOI 10.6039/j.issn.1001-0408.2024.14.12

摘 要 目的 观察维奈克拉联合高三尖杉酯碱和阿糖胞苷治疗急性髓系白血病（AML）的近期疗效和安全性。方法 回顾性收
集2022年10月至2023年11月我院收治的40例初诊AML患者资料，根据治疗方案分为观察组和对照组，每组20例。对照组患者
给予注射用盐酸柔红霉素+注射用阿糖胞苷，观察组患者给予维奈克拉片+高三尖杉酯碱注射液+注射用阿糖胞苷。两组患者均
以 28 d 为 1 个周期，诱导化疗 1 个周期后评价近期疗效、微小残留病（MRD）阴性率、粒细胞缺乏持续时间、血小板计数（PLT）＜
20×10 L 持续时间、悬浮红细胞输注量及血小板输注量，以及不良反应发生情况。结果 观察组患者的完全缓解或完全缓解伴
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血液学不完全恢复（CR/CRi）率显著高于对照组（P＜0.05），且在 CR/CRi 患者中，观察组患者的 MRD 阴性率也显著高于对照组
（P＜0.05）；但在低、中、高危患者中，两组患者的CR/CRi率比较，差异均无统计学意义（P＞0.05）。两组患者的粒细胞缺乏持续时
间、PLT＜20×10 L 持续时间、悬浮红细胞输注量、血小板输注量、血液学毒性反应发生率及非血液学毒性反应发生率比较，差异
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均无统计学意义（P＞0.05）。结论 维奈克拉联合高三尖杉酯碱和阿糖胞苷治疗AML的近期疗效和安全性较均好。
关键词 急性髓系白血病；维奈克拉；高三尖杉酯碱；阿糖胞苷；疗效；安全性

Clinical observation of venetoclax combined with homoharringtonine and cytarabine in the treatment of
acute myeloid leukemia
ZHOU Ling，PENG Qiuyuan，ZHAO Pan，WEI Jin，LIN Xiaojing，ZOU Xingli，LUO Wenfeng，WANG Jing，XIE
Kunying，LI Xianglong，LIU Yang，NI Xun（Dept. of Hematology， the Affiliated Hospital of North Sichuan
Medical College， Sichuan Nanchong 637000， China）

ABSTRACT OBJECTIVE To observe the short-term efficacy and safety of venetoclax combined with homoharringtonine and
cytarabine in the treatment of acute myeloid leukemia （AML）. METHODS The data of 40 newly diagnosed AML patients admitted
to our hospital from October 2022 to November 2023 were retrospectively collected and divided into observation group and control
group according to treatment plan， with 20 cases in each group. The patients in the control group were given Daunorubicin
hydrochloride for injection+Cytarabine for injection， and the patients in the observation group were given Venetoclax tablets+
Homoharringtonine injection+Cytarabine for injection. The patients in both groups were given relevant medicine， with 28 days as
one cycle. The short-term efficacy， negative rate of minimal residual disease （MRD）， duration of granulocyte deficiency， duration
of platelet （PLT） ＜20×10 L ， transfusion volume of suspended red blood cells and platelet， and the occurrence of adverse drug
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reactions were evaluated in both groups after 1 cycle of induction chemotherapy. RESULTS The complete remission or complete
remission with incomplete hematologic recovery （CR/CRi） rate in the observation group was significantly higher than control group
（P＜0.05）， and the negative rate of MRD in the observation group was also significantly higher than control group （P＜0.05）.
However， in low-， medium- and high-risk patients， there was no statistical significance in CR/CRi rates between the two groups
（P＞0.05）. There were no significant differences in the duration of agranulocytosis， the duration of PLT ＜20×10 L ， the amount
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of suspended red blood cell transfusion， the amount of platelet transfusion， the incidence of hematologic toxicity and the incidence
of non-hematologic toxicity between 2 groups （P＞0.05）. CONCLUSIONS Venetoclax combined with homoharringtonine and
cytarabine show good short-term efficacy and safety in the
Δ 基金项目 四川省医学会医学科研课题（No.S17028）
＊第一作者 住院医师，硕士研究生。研究方向：血液病学。 treatment of AML.
E-mail：3201663349@qq.com KEYWORDS acute myeloid leukemia； venetoclax；
# 通信作者 副主任医师，副教授，硕士生导师，硕士。研究方向： homoharringtonine； cytarabine； efficacy； safety
血液病学。E-mail：435312292@qq.com

中国药房 2024年第35卷第14期 China Pharmacy 2024 Vol. 35 No. 14 · 1743 ·