Page 47 - 《中国药房》2024年10期
P. 47
综上所述,水蛭可能通过激活 PPARγ、SIRT1 蛋白 粥样硬化并发非酒精性脂肪肝氧化应激损伤和纤维化
的表达来调节肝脏脂质代谢、抑制炎症反应,从而发挥 的作用研究[J]. 时珍国医国药,2023,34(1):1-5.
对 NAFLD 的改善作用,但更深层次的分子机制尚有待 FENG X T,DU M,ZHANG Y F,et al. Effect of Taohong-
进一步研究探讨。 yin decoction on oxidative stress injury and fibrosis of
参考文献 atherosclerosis with non-alcoholic fatty liver in ApoE -/-
mice[J]. Lishizhen Med Mater Med Res,2023,34(1):1-5.
[ 1 ] GOLABI P,SHAH D,YOUNOSSI Z M. How to identify
[10] 徐永妘,张磊,张宇,等. 基于网络药理学和实验研究探
advanced nonalcoholic fatty liver disease in the primary
讨加味甘姜苓术汤对非酒精性脂肪肝小鼠模型影响及
care setting[J]. Semin Liver Dis,2023,43(2):142-148.
作用机制[J]. 世界中西医结合杂志,2023,18(1):74-84.
[ 2 ] LEE E,KORF H,VIDAL-PUIG A. An adipocentric
XU Y Y,ZHANG L,ZHANG Y,et al. Effect of modified
perspective on the development and progression of
Ganjiang lingzhu decoction on nonalcoholic fatty liver in
non-alcoholic fatty liver disease[J]. J Hepatol,2023,78
mice and its mechanism based on network pharmacology
(5):1048-1062.
and experiments[J]. World J Integr Tradit West Med,
[ 3 ] PETRESCU M,VLAICU S I,CIUMĂRNEAN L,et al.
2023,18(1):74-84.
Chronic inflammation:a link between nonalcoholic fatty
[11] YOUNOSSI Z,ANSTEE Q M,MARIETTI M,et al.
liver disease(NAFLD)and dysfunctional adipose tissue
Global burden of NAFLD and NASH:trends,predictions,
[J]. Medicina,2022,58(5):641.
risk factors and prevention[J]. Nat Rev Gastroenterol
[ 4 ] CHEN H,TAN H B,WAN J,et al. PPAR-γ signaling in
Hepatol,2018,15(1):11-20.
nonalcoholic fatty liver disease:pathogenesis and thera‐
[12] WONG V W,EKSTEDT M,WONG G L,et al. Changing
peutic targets[J]. Pharmacol Ther,2023,245:108391.
epidemiology,global trends and implications for out‐
[ 5 ] GREGORIO E D,COLELL A,MORALES A,et al. Rele-
comes of NAFLD[J]. J Hepatol,2023,79(3):842-852.
vance of SIRT1-NF-κB axis as therapeutic target to ame‐
[13] LE Y F,GUO J N,LIU Z J,et al. Calenduloside E ame-
liorate inflammation in liver disease[J]. Int J Mol Sci,
liorates non-alcoholic fatty liver disease via modulating a
2020,21(11):3858.
pyroptosis-dependent pathway[J]. J Ethnopharmacol,2024,
[ 6 ] 韩倩倩,温紫云,吕晴,等. 含水蛭中成药治疗动脉粥样
319(Pt 2):117239.
硬化的网状 Meta 分析[J]. 中国中药杂志,2023,48(1):
[14] ZENG C F,CHEN M K. Progress in nonalcoholic fatty
234-246.
liver disease:SIRT family regulates mitochondrial bioge-
HAN Q Q,WEN Z Y,LYU Q,et al. Network meta-
nesis[J]. Biomolecules,2022,12(8):1079.
analysis of Chinese patent medicine containing Hirudo in
[15] LIOU C J,LEE Y K,TING N C,et al. Protective effects
treatment of atherosclerosis[J]. China J Chin Mater Med,
of licochalcone A ameliorates obesity and non-alcoholic
2023,48(1):234-246.
fatty liver disease via promotion of the Sirt-1/AMPK path‐
[ 7 ] 徐寒莹,张冬梅,卢靖,等. 水蛭治疗脑卒中的作用机制
way in mice fed a high-fat diet[J]. Cells,2019,8(5):447.
研究进展[J]. 中国实验方剂学杂志,2023,29(18):
[16] SINGH V,UBAID S. Role of silent information regulator
209-217.
1(SIRT1)in regulating oxidative stress and inflammation
XU H Y,ZHANG D M,LU J,et al. Mechanism of Hirudo
[J]. Inflammation,2020,43(5):1589-1598.
in treatment of stroke:a review[J]. Chin J Exp Tradit Med
[17] YANG Y S,LIU Y,WANG Y W,et al. Regulation of
Formulae,2023,29(18):209-217.
SIRT1 and its roles in inflammation[J]. Front Immunol,
[ 8 ] WU J K,YANG Q. Effect of leech on lipid metabolism
2022,13:831168.
and liver in hyperlipidemia rats[J]. Zhongguo Zhong Yao
(收稿日期:2023-11-16 修回日期:2024-03-08)
Za Zhi,2018,43(4):794-799.
(编辑:张元媛)
[ 9 ] 冯骁腾,杜敏,张一凡,等. 桃红饮减轻ApoE -/- 小鼠动脉
中国药房 2024年第35卷第10期 China Pharmacy 2024 Vol. 35 No. 10 · 1197 ·