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综上所述,盐酸艾司氯胺酮鼻喷剂起效迅速,生物                               balance  of  excitatory/inhibitory  synaptic  activity[J].
          利用度较高,纤毛毒性较小。                                            Neuropharmacology,2023,225:109357.
          参考文献                                                [ 8 ]  郭卓瑶,梅丽,纪梁缘,等. 妥布霉素注射剂雾化吸入对

          [ 1 ]  TOKI H,YAMAGUCHI J I,MIZUNO-YASUHIRA A,et         呼吸道纤毛的毒性研究[J]. 中国临床药理学杂志,2023,
                                                                   39(12):1679-1683.
               al. Chiral LC-MS/MS method for the simultaneous deter‐
                                                                   GUO Z Y,MEI L,JI L Y,et al. Respiratory ciliary toxicity
               mination  of(R,S)-ketamine,(R,S)-norketamine,and
                                                                   study  of  tobramycin  injection  administrated  by  nebuli-
              (2R,6R;2S,6S)-hydroxynorketamine  in  mouse  plasma
                                                                   zation[J].  Chin  J  Clin  Pharmacol,2023,39(12):1679-
               and brain[J]. J Pharm Biomed Anal,2023,224:115168.
                                                                   1683.
          [ 2 ]  王丹君,沈家豪,王清秀. 艾司氯胺酮临床应用的研究进
                                                              [ 9 ]  ZHANG  T,LI  M,HAN  X  L,et  al.  Effect  of  different
               展[J]. 同济大学学报(医学版),2024,45(1):158-164.
                                                                   absorption enhancers on the nasal absorption of nalmefene
               WANG D J,SHEN J H,WANG Q X. Research progress
                                                                   hydrochloride[J]. AAPS PharmSciTech,2022,23(5):143.
               on  clinical  application  of  esketamine[J].  J  Tongji  Univ
                                                              [10]  王丹 . 甲状旁腺激素鼻喷剂开发研究报告[D]. 延吉:延
               Med Sci,2024,45(1):158-164.
                                                                   边大学,2019.
          [ 3 ]  SHOIB  S,KOTRA  M,JAVED  S,et  al.  Esketamine:
                                                                   WANG D. Report on the development of parathyroid hor‐
               a quick-acting novel antidepressant without the disadvan‐
                                                                   mone nasal spray[D].Yanji:Yanbian University,2019.
               tages of ketamine[J]. Horm Mol Biol Clin Investig,2022,
                                                              [11]  TAI J H,HAN M,LEE D B,et al. Different methods and
               43(4):505-511.
                                                                   formulations  of  drugs  and  vaccines  for  nasal  administra‐
          [ 4 ]  HARE B D,POTHULA S,DILEONE R J,et al. Ketamine
                                                                   tion[J]. Pharmaceutics,2022,14(5):1073.
               increases vmPFC activity:effects of(R)- and(S)-stereo‐
                                                              [12]  TÜRKER  S,ONUR  E,OZER  Y.  Nasal  route  and  drug
               isomers and(2R,6R)-hydroxynorketamine metabolite[J].
                                                                   delivery  systems[J].  Pharm  World  Sci,2004,26(3):
               Neuropharmacology,2020,166:107947.
                                                                   137-142.
          [ 5 ]  MATŁOKA M,JANOWSKA S,GAJOS-DRAUS A,et al.
                                                              [13]  LOCHHEAD  J  J,THORNE  R  G.  Intranasal  delivery  of
               Esketamine inhaled as dry powder:pharmacokinetic,phar‐
                                                                   biologics to the central nervous system[J]. Adv Drug
               macodynamic and safety assessment in a preclinical study
                                                                   Deliv Rev,2012,64(7):614-628.
               [J]. Pulm Pharmacol Ther,2022,73/74:102127.    [14]  国家药典委员会. 中华人民共和国药典:四部[M]. 2020
          [ 6 ]  LOCHHEAD J J,DAVIS T P. Perivascular and perineural   年版. 北京:中国医药科技出版社,2020:12,466-472.
               pathways  involved  in  brain  delivery  and  distribution  of   National  Pharmacopoeia  Commission.  Pharmacopoeia  of
               drugs  after  intranasal  administration[J].  Pharmaceutics,  the People’s Republic of China:part Ⅳ[M]. 2020 edition.
               2019,11(11):598.                                    Beijing:China  Medical  Science  and  Technology  Press,
          [ 7 ]  NGUYEN T M L,DEFAIX C,MENDEZ-DAVID I,et al.       2020:12,466-472.
               Intranasal (R,S)-ketamine  delivery  induces  sustained      (收稿日期:2023-11-29  修回日期:2024-04-11)
               antidepressant  effects  associated  with  changes  in  cortical                   (编辑:邹丽娟)




























          · 1178 ·    China Pharmacy  2024 Vol. 35  No. 10                            中国药房  2024年第35卷第10期
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