Page 127 - 《中国药房》2024年7期
P. 127

[10]  WITKOWSKI M T.Modulation of CD19 surface expres‐  [23]  CORDOBA  S,ONUOHA  S,THOMAS  S,et  al.  CAR T
              sion in B cell acute lymphoblastic leukemia[J]. Nat Immu‐  cells with dual targeting of CD19 and CD22 in pediatric
              nol,2022,23:1410-1411.                              and young adult patients with relapsed or refractory B cell
          [11]  MILONE M C,XU J,CHEN S J,et al. Engineering en‐   acute  lymphoblastic  leukemia:a  phase  Ⅰ  trial[J].  Nat
              hanced CAR T-cells for improved cancer therapy[J]. Nat   Med,2021,27(10):1797-1805.
              Cancer,2021,2(8):780-793.                      [24]  BOURNAZOS S,GUPTA A,RAVETCH J V. The role of
          [12]  PACENTA H L,LAETSCH T W,JOHN S. CD19 CAR T        IgG  Fc  receptors  in  antibody-dependent  enhancement[J].
              cells  for  the  treatment  of  pediatric  pre-B  cell  acute  lym‐  Nat Rev Immunol,2020,20(10):633-643.
              phoblastic leukemia[J]. Paediatr Drugs,2020,22(1):1-11.  [25]  LOCATELLI F,ECKERT C,HRUSAK O,et al. Blinatu‐
          [13]  YANG J F,HE J P,ZHANG X,et al. Next-day manufac‐  momab overcomes poor prognostic impact of measurable
              ture of a novel anti-CD19 CAR-T therapy for B-cell acute   residual  disease  in  pediatric  high-risk  first  relapse  B-cell
              lymphoblastic  leukemia:first-in-human  clinical  study[J].   precursor acute lymphoblastic leukemia[J]. Pediatr Blood
              Blood Cancer J,2022,12(7):104.                      Cancer,2022,69(8):e29715.
          [14]  NOVARTIS.  Novartis  five-year  Kymriah   data  show  du‐  [26]  BROWN P A,JI L Y,XU X X,et al. Effect of postrein‐
                                             ®
              rable remission and long-term survival maintained in chil‐  duction therapy consolidation with blinatumomab vs. che‐
              dren and young adults with advanced B-cell ALL[EB/OL].  motherapy  on  disease-free  survival  in  children,adoles‐
              (2022-06-12)[2024-03-15]. https://finance.yahoo.com/  cents,and young adults with first relapse of B-cell acute
              news/novartis-five-kymriah-data-show-093000684.html.  lymphoblastic  leukemia:a  randomized  clinical  trial[J].
          [15]  KOKALAKI E,MA B,FERRARI M,et al. Dual targeting   JAMA,2021,325(9):833-842.
              of  CD19  and  CD22  against  B-ALL  using  a  novel  high-  [27]  ISSA G C,ALDOSS I,DIPERSIO J,et al. The menin in‐
              sensitivity aCD22 CAR[J]. Mol Ther,2024,32(2):556-558.  hibitor  revumenib  in  KMT2A-rearranged  or  NPM1-mu‐
          [16]  ZANETTI S R,VELASCO-HERNANDEZ T,GUTIERREZ-        tant leukaemia[J]. Nature,2023,615(7954):920-924.
              AGÜERA  F,et  al. A  novel  and  efficient  tandem  CD19-   [28]  WEN  J  Q,ZHOU  M,SHEN Y  L,et  al.  Poor  treatment
              and  CD22-directed  CAR  for  B  cell  ALL[J].  Mol  Ther,  responses  were  related  to  poor  outcomes  in  pediatric  B
              2022,30(2):550-563.                                 cell acute lymphoblastic leukemia with KMT2A rearrange‐
          [17]  SHAH  N  N,HIGHFILL  S  L,SHALABI  H,et  al.  CD4/  ments[J]. BMC Cancer,2022,22(1):859.
              CD8  T-cell  selection  affects  chimeric  antigen  receptor   [29]  PIETERS R,LORENZO P D,ANCLIFFE P,et al. Out‐
              (CAR) T-cell potency and toxicity:updated results from a   come of infants younger than 1 year with acute lympho‐
              phase  Ⅰ  anti-CD22  CAR  T-cell  trial[J].  J  Clin  Oncol,  blastic leukemia treated with the interfant-06 protocol:re‐
              2020,38(17):1938-1950.                              sults from an international phase Ⅲ randomized study[J].
          [18]  FRY T  J,SHAH  N  N,ORENTAS  R  J,et  al.  CD22-tar‐  J Clin Oncol,2019,37(25):2246-2256.
              geted  CAR  T  cells  induce  remission  in  B-ALL  that  is       [30]  VAN DER SLUIS I M,LORENZO P D,KOTECHA R S,
              naive or resistant to CD19-targeted CAR immunotherapy  et al. Blinatumomab added to chemotherapy in infant lym‐
              [J]. Nat Med,2018,24(1):20-28.                      phoblastic  leukemia[J].  N  Engl  J  Med,2023,388(17):
          [19]  COHEN A D,GARFALL A L,STADTMAUER E A,et al.       1572-1581.
              B cell maturation antigen-specific CAR T cells are clini‐  [31]  RUBINSTEIN  J  D,O’BRIEN  M  M.  Inotuzumab  ozo‐
              cally active in multiple myeloma[J]. J Clin Invest,2019,  gamicin in B-cell precursor acute lymphoblastic leukemia:
              129(6):2210-2221.                                   efficacy,toxicity,and  practical  considerations[J].  Front
          [20]  HU Y X,ZHOU Y L,ZHANG M M,et al. CRISPR/Cas9-     Immunol,2023,14:1237738.
              engineered  universal  CD19/CD22  dual-targeted  CAR-T   [32]  BRIVIO E,LOCATELLI F,LOPEZ-YURDA M,et al. A
              cell  therapy  for  relapsed/refractory  B-cell  acute  lympho‐  phase Ⅰ study of inotuzumab ozogamicin in pediatric re‐
              blastic leukemia[J]. Clin Cancer Res,2021,27(10):2764-  lapsed/refractory  acute  lymphoblastic  leukemia (ITCC-
              2772.                                               059 study)[J]. Blood,2021,137(12):1582-1590.
          [21]  SHALABI  H,QIN  H Y,SU A,et  al.  CD19/22  CAR  T   [33]  PENNESI E,MICHELS N,BRIVIO E,et al. Inotuzumab
              cells in children and young adults with B-ALL:phase Ⅰ   ozogamicin  as  single  agent  in  pediatric  patients  with  re‐
              results  and  development  of  a  novel  bicistronic  CAR[J].   lapsed  and  refractory  acute  lymphoblastic  leukemia:re‐
              Blood,2022,140(5):451-463.                          sults  from  a  phase  Ⅱ  trial[J].  Leukemia,2022,36(6):
          [22]  SPIEGEL J Y,PATEL S,MUFFLY L,et al. CAR T cells   1516-1524.
              with  dual  targeting  of  CD19  and  CD22  in  adult  patients   (收稿日期:2023-08-20  修回日期:2024-03-15)
              with recurrent or refractory B cell malignancies:a phase 1                          (编辑:胡晓霖)
              trial[J]. Nat Med,2021,27(8):1419-1431.




          中国药房  2024年第35卷第7期                                                 China Pharmacy  2024 Vol. 35  No. 7    · 889 ·
   122   123   124   125   126   127   128   129   130   131   132