Page 117 - 《中国药房》2023年20期
P. 117
注了单核苷酸多态性,纳入的样本量较少,不能完全解 Genomewide association between GLCCI1 and response
释 ICSs 应答的个体差异,且 ACO 患者经 ICSs 治疗的临 to glucocorticoid therapy in asthma[J]. N Engl J Med,
床获益机制还需进一步研究。(3)基于药物的易获得性, 2011,365(13):1173-1183.
本研究以沙美特罗替卡松代表ICSs,所得结果是否可外 [ 9 ] RIJAVEC M,ŽAVBI M,LOPERT A,et al. GLCCI1 poly‐
推到其他ICSs暂不清楚。(4)支气管扩张剂联合ICSs治 morphism rs37973 and response to treatment of asthma
with inhaled corticosteroids[J]. J Investig Allergol Clin
疗可能会影响ICSs的疗效。在后续研究中,本课题组将
Immunol,2018,28(3):165-171.
进一步完善 GLCCI1 基因 rs37973 位点单倍型研究和体
[10] LEI Y,GAO Y P,CHEN J K,et al. GLCCI1 rs37973:a
外荧光素酶报告基因试验,并评价突变位点对 GLCCI1
potential genetic predictor of therapeutic response to
基因表达及炎症细胞因子凋亡的影响,以探索不同基因
inhaled corticosteroids in Chinese chronic obstructive
型对ICSs应答差异的机制。 pulmonary disease patients[J]. Sci Rep,2017,7:42552.
综上所述,GLCCI1基因rs37973位点GG型ACO患 [11] HARDIN M,CHO M,MCDONALD M L,et al. The clini‐
者对ICSs的治疗反应较其他基因型差,其中吸烟史>20 cal and genetic features of COPD-asthma overlap syn‐
包年的患者反应更差。 drome[J]. Eur Respir J,2014,44(2):341-350.
参考文献 [12] MILLER M R,HANKINSON J,BRUSASCO V,et al.
[ 1 ] GBD Chronic Respiratory Diseases Collaborators. Global Standardisation of spirometry[J]. Eur Respir J,2005,26
burden of chronic respiratory diseases and risk factors, (2):319-338.
1990-2019:an update from the Global Burden of Disease [13] CGS Report. Terminology,definitions,and classification
Study 2019[J]. EClinicalMedicine,2023,59:101936. of chronic pulmonary emphysema and related conditions
[ 2 ] Global Initiative for Asthma,Global Initiative for Chronic [J]. Thorax,1959,14(4):286-299.
Obstructive Lung Disease. Diagnosis of diseases of chronic [14] POSTMA D S,WEISS S T,VAN DEN BERGE M,et al.
airflow limitation:asthma COPD and asthma-COPD over‐ Revisiting the Dutch hypothesis[J]. J Allergy Clin Immu‐
lap syndrome(ACOS)[EB/OL]. [2022-12-23]. https:// nol,2015,136(3):521-529.
goldcopd. org/wp-content/uploads/2016/04/GOLD_ACOS_ [15] MIRAVITLLES M. Asthma-COPD overlap(ACO)PRO-
2015.pdf. CON debate. ACO:call me by my name[J]. COPD,2020,
[ 3 ] WOODRUFF P G,VAN DEN BERGE M,BOUCHER R 17(5):471-473.
C,et al. American Thoracic Society/national heart,lung, [16] CHAPMAN M S,QU N,PASCOE S,et al. Isolation of
and blood institute asthma-chronic obstructive pulmonary differentially expressed sequence tags from steroid-
disease overlap workshop report[J]. Am J Respir Crit Care responsive cells using mRNA differential display[J]. Mol
Med,2017,196(3):375-381. Cell Endocrinol,1995,108(1/2):R1-R7.
[ 4 ] VAZ FRAGOSO C A,MURPHY T E,AGOGO G O,et [17] IZUHARA Y,MATSUMOTO H,KANEMITSU Y,et al.
al. Asthma-COPD overlap syndrome in the US:a prospec‐ GLCCI1 variant accelerates pulmonary function decline in
tive population-based analysis of patient-reported out‐ patients with asthma receiving inhaled corticosteroids[J].
comes and health care utilization[J]. Int J Chron Obstruct Allergy,2014,69(5):668-673.
Pulmon Dis,2017,12:517-527. [18] POSTMA D S,KERKHOF M,BOEZEN H M,et al.
[ 5 ] HIKICHI M,HASHIMOTO S,GON Y. Asthma and Asthma and chronic obstructive pulmonary disease:com‐
COPD overlap pathophysiology of ACO[J]. Allergol Int, mon genes,common environments?[J]. Am J Respir Crit
2018,67(2):179-186. Care Med,2011,183(12):1588-1594.
[ 6 ] SIN D D,MIRAVITLLES M,MANNINO D M,et al. [19] ANTHONISEN N R,CONNETT J E,MURRAY R P.
What is asthma-COPD overlap syndrome? Towards a con‐ Smoking and lung function of lung health study partici‐
sensus definition from a round table discussion[J]. Eur pants after 11 years[J]. Am J Respir Crit Care Med,2002,
Respir J,2016,48(3):664-673. 166(5):675-679.
[ 7 ] JANG A S,LEE J H,PARK S W,et al. Factors influen- [20] MIRAVITLLES M. Diagnosis of asthma-COPD overlap:
cing the responsiveness to inhaled glucocorticoids of the five commandments[J]. Eur Respir J,2017,49(5):
patients with moderate-to-severe asthma[J]. Chest,2005, 1700506.
128(3):1140-1145. (收稿日期:2023-07-10 修回日期:2023-09-22)
[ 8 ] TANTISIRA K G,LASKY-SU J,HARADA M,et al. (编辑:陈 宏)
中国药房 2023年第34卷第20期 China Pharmacy 2023 Vol. 34 No. 20 · 2539 ·