Page 127 - 《中国药房》2023年18期

黄酮类中药单体对肺纤维化信号通路调控作用的研究进展
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蒙建华 ，刘 锐 ，潘 玲 ，罗珍贞 ，宋伟贤 ，陆 珏（1.广西中医药大学研究生院，南宁 530004；2.广西中
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医药大学附属瑞康医院呼吸与危重症医学科，南宁 530001）
中图分类号 R96；R285 文献标志码 A 文章编号 1001-0408（2023）18-2293-06
DOI 10.6039/j.issn.1001-0408.2023.18.22
摘 要 肺纤维化是一种慢性、进行性、不可逆的间质性肺疾病，目前尚无治疗肺纤维化的特效药。许多中药单体表现出对肺纤
维化具有潜在的治疗价值，其中以黄酮类化合物为主要代表。黄芪总黄酮、灯盏花乙素等可通过干预转化生长因子-β/果蝇MAD
蛋白信号通路减轻炎症细胞浸润，减轻肺损伤和细胞外基质（ECM）沉积；镰形棘豆总黄酮、红景天苷可通过介导JAK/信号转导及
转录激活因子信号通路抑制肺组织炎症反应，阻止上皮间质转化（EMT）进程；槲皮素、银杏叶提取物等可通过抑制核因子κB信号
通路来减少巨噬细胞凋亡，发挥抗肺纤维化作用；漆黄素、原花青素可通过磷脂酰肌醇3-激酶/蛋白激酶B/哺乳动物雷帕霉素靶蛋
白信号通路，促使肌成纤维细胞形态学恢复，减少ECM沉积；柚皮素、木犀草素可通过NOD样受体热蛋白结构域相关蛋白3信号
通路抑制巨噬细胞焦亡和炎症反应，改善肺功能及肺组织损伤；余甘子醇提物、毛蕊异黄酮可通过激活核转录因子红系2相关因
子2/抗氧化响应元件信号通路，改善肺组织炎症损伤和纤维化；异甘草素则可通过抑制胞外信号调节激酶信号通路阻止上皮细胞
表型转化，逆转EMT进展。后续学者可考虑开发适当的药物载体，提高其生物利用度，深入研究药物的作用靶点和途径，为黄酮
类中药单体走向临床实践提供依据。
关键词 肺纤维化；黄酮类；中药单体；作用机制；信号通路

Research progress of the regulation effect of traditional Chinese medicine monomer of flavonoids on the
pulmonary fibrosis signaling pathway
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MENG Jianhua ，LIU Rui ，PAN Ling ，LUO Zhenzhen ，SONG Weixian ，LU Jue（1. Graduate School， Guangxi
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University of Chinese Medicine，Nanning 530004，China；2. Dept. of Pulmonary and Critical Care Medicine，
Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine， Nanning 530001， China）
ABSTRACT Pulmonary fibrosis is a chronic， progressive and irreversible interstitial lung disease. At present， there is no specific
drug for the treatment of pulmonary fibrosis， and many TCM monomers have potential therapeutic value for pulmonary fibrosis，
among which flavonoids are the main representative. For example， total flavones of Astragalus memeranaceus and scutellarin can
reduce inflammatory cell infiltration， lung injury and extracellular matrix （ECM） deposition by interfering with transforming
growth factor-β1/drosophila MAD protein signaling pathway. Total flavonoids of Oxytropis falcata Bunge and salidroside can inhibit
lung inflammation by mediating JAK/signal transduction and transcriptional activator signaling pathway， and prevent the epithelial
interstitial transition （EMT） process. Quercetin and Ginkgo biloba leaf extract can reduce the apoptosis of macrophages by
inhibiting the nuclear factor-κB signaling pathway and play an anti-pulmonary fibrosis role. Urushetin and proanthocyanidins can
promote the morphological recovery of myofibroblasts and reduce ECM deposition through the phosphatidylinositol 3-kinase/protein
kinase B/mammalian target protein of rapamycin signaling pathway. Naringin and luteolin can inhibit scorch death of macrophage
and inflammation response， and improve lung function and lung tissue injury through NOD-like receptor heat protein domain
related protein 3 signaling pathway. The ethanol extract of Phyllanthus emblica and calycosin can improve the inflammatory injury
and fibrosis of lung tissue by activating the signaling pathway of nuclear transcription factor erythro2-related factor 2/antioxidant
response element. Isogliquiritin can inhibit the phenotypic transformation of epithelial cells and reverse EMT progression by
inhibiting extracellular signal-regulating kinase signaling pathway. In the future， scholars should consider developing appropriate
drug carriers to improve their bioavailability and further study
Δ 基金项目 国家自然科学基金项目（No.81860829）；广西自然科
drug targets and pathways， to provide evidence for the
学基金项目（No.2020GXNSFAA297158）；广西中医药大学自然科学研
development of traditional Chinese medicine monomers of
究项目（No.2019MS031）
＊第一作者 硕士研究生。研究方向：中西医结合防治呼吸系统疾 flavonoids into clinical practice.
病。E-mail：821302161@qq.com KEYWORDS pulmonary fibrosis； flavonoid； traditional
# 通信作者 主任医师，教授，硕士生导师。研究方向：中西医结合 Chinese medicine monomer； mechanism； signaling pathway
防治呼吸系统疾病。E-mail：215678120@qq.com

中国药房 2023年第34卷第18期 China Pharmacy 2023 Vol. 34 No. 18 · 2293 ·