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染的药物治疗方法主要涉及微生态治疗药物、生物制                                  tine childhood vaccines in infants in the United States:re‐
          剂、抗感染药、胃肠用药、中药等,目前尚无抗轮状病毒                                sults from a phase 3,randomized trial[J]. Vaccine,2021,
                  [38]
          的特效药 。因此,亟须梳理国内外药物研究进展,通                                 39(10):1534-1543.
          过对已有药物进行结构优化,借助计算机辅助设计,依                            [12]  BLACK R,FONTAINE O,LAMBERTI L,et al. Drivers
                                                                   of  the  reduction  in  childhood  diarrhea  mortality  1980-
          据靶点蛋白结构筛选新结构药物,以寻找新靶点,建立
                                                                   2015  and  interventions  to  eliminate  preventable  diarrhea
          新模型,发现新先导化合物;同时,积极开展基于细胞/在
                                                                   deaths by 2030[J]. J Glob Health,2019,9(2):020801.
          体药理机制的研究,或从临床药物中挖掘新功能等,以
                                                              [13]  GUARINO  A,AGUILAR  J,BERKLEY  J,et  al.  Acute
          加快抗轮状病毒药物的自主研发和创新。
                                                                   gastroenteritis in children of the world:what needs to be
          参考文献                                                     done? [J].  J  Pediatr  Gastroenterol  Nutr,2020,70(5):
          [ 1 ]  ZHAO G W,REN X F. Rotavirus infections:mechanisms,  694-701.
               prevention  and  treatment[J].  World  Chin  J  Dig,2013,  [14]  HIGGINS J P T,GREEN S. Assessing risk of bias in in‐
               21(1):60.                                           cluded studies:Cochrane handbook for systematic reviews
          [ 2 ]  STANIFER M,BOULANT S. The origin of diarrhea in ro‐  of interventions 5.1.0[EB/OL]. [2022-05-10]. http://www.
               tavirus infection[J]. Science,2020,370(6519):909-910.  handbook-5-1.cochrane.org.
          [ 3 ]  WIKSWO  M  E,PARASHAR  U  D,LOPMAN  B,et  al.   [15]  NARAYANAPPA  D.  Randomized  double  blinded  con‐
               Evidence  for  household  transmission  of  rotavirus  in  the   trolled trial to evaluate the efficacy and safety of Bifilac in
               United  States,2011-2016[J].  J  Pediatric  Infect  Dis  Soc,  patients  with  acute  viral  diarrhea[J].  Indian  J  Pediatr,
               2020,9(2):181-187.                                  2008,75(7):709-713.
          [ 4 ]  李瑛.小儿轮状病毒肠炎流行病学特点及医院感染控制                     [16]  SARKER  S  A,JÄKEL  M,SULTANA  S,et  al.  Anti-
               [J].现代预防医学,2014,41(8):1506-1507.                    rotavirus protein reduces stool output in infants with diar‐
          [ 5 ]  ENGEVIK M A,BANKS L D,ENGEVIK K A,et al. Rota‐    rhea:a  randomized  placebo-controlled  trial[J].  Gastroen‐
               virus  infection  induces  glycan  availability  to  promote           terology,2013,145(4):740-748.e8.
               ileum-specific changes in the microbiome aiding rotavirus   [17]  HUANG  Y  F,LIU  P  Y,CHEN  Y  Y,et  al.  Three-
               virulence[J]. Gut Microbes,2020,11(5):1324-1347.    combination  probiotics  therapy  in  children  with  salmo‐
          [ 6 ]  FLOREZ  I  D, NIÑO-SERNA  L  F, BELTRÁN-          nella and rotavirus gastroenteritis[J]. J Clin Gastroenterol,
               ARROYAVE C P. Acute infectious diarrhea and gastroen‐  2014,48(1):37-42.
               teritis in children[J]. Curr Infect Dis Rep,2020,22(2):4.  [18]  FANG S B,LEE H C,HU J J,et al. Dose-dependent ef‐
          [ 7 ]  SEN A,NAMSA N D,FENG N G,et al. Rotavirus repro‐  fect of Lactobacillus rhamnosus on quantitative reduction
               grams multiple interferon receptors and restricts their in‐  of faecal rotavirus shedding in children[J]. J Trop Pediatr,
               testinal  antiviral  and  inflammatory  functions[J].  J  Virol,  2009,55(5):297-301.
               2020,94(6):e01775-19.                          [19]  ROSSIGNOL  J  F,ABU-ZEKRY  M,HUSSEIN A,et  al.
          [ 8 ]  LAU  Y  L,FAN  LEUNG  T,SIRVAN  CETIN  B,et  al.   Effect  of  nitazoxanide  for  treatment  of  severe  rotavirus
               Safety  and  reactogenicity  of  a  liquid  formulation  of  hu‐  diarrhoea:randomised  double-blind  placebo-controlled
               man  rotavirus  vaccine(porcine  circovirus-free):a  phase   trial[J]. Lancet,2006,368(9530):124-129.
               Ⅲ ,observer-blind,randomized,multi-country  study[J].   [20]  SUBBOTINA M D,TIMCHENKO V N,VOROBYOV M
               Vaccine,2022,40(14):2184-2190.                      M,et al. Effect of oral administration of tormentil root ex‐
          [ 9 ]  GROOME M J,FAIRLIE L,MORRISON J,et al. Safety     tract(Potentilla tormentilla)on rotavirus diarrhea in chil‐
               and immunogenicity of a parenteral trivalent P2-VP8 subu-  dren:a  randomized,double  blind,controlled  trial[J].  Pe-
               nit  rotavirus  vaccine:a  multisite,randomised,double-  diatr Infect Dis J,2003,22(8):706-711.
               blind,placebo-controlled trial[J]. Lancet Infect Dis,2020,  [21]  DAS  S,GUPTA  P  K,DAS  R  R.  Efficacy  and  safety  of
               20(7):851-863.                                      Saccharomyces  boulardii  in  acute  rotavirus  diarrhea:
          [10]  WU Z W,LI Q L,ZHOU H S,et al. Safety and immuno‐   double  blind  randomized  controlled  trial  from  a  develo-
               genicity  of  a  novel  oral  hexavalent  rotavirus  vaccine:a   ping country[J]. J Trop Pediatr,2016,62(6):464-470.
               phase Ⅰ clinical trial[J]. Hum Vaccin Immunother,2021,  [22]  MARKOVINOVIĆ L,KNEZOVIĆ I,KNIEWALD T,et
               17(7):2311-2318.                                    al.  Enteroadsorbent  polymethylsiloxane  polyhydrate  vs.
          [11]  ABU-ELYAZEED R,KLEIN N P,MOERMAN L,et al.          probiotic  Lactobacillus  reuteri  DSM  17938  in  the  treat‐
               Concomitant administration of a liquid formulation of hu‐  ment of rotaviral gastroenteritis in infants and toddlers,a
               man  rotavirus  vaccine(porcine  circovirus-free)with  rou‐  randomized  controlled  trial[J].  Front  Pediatr,2020,8:


          · 1766 ·    China Pharmacy  2023 Vol. 34  No. 14                            中国药房  2023年第34卷第14期
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