Page 128 - 《中国药房》2023年6期

·综述·

艾叶的炮制历史沿革及现代研究进展
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张晓霞 1， 2， 3＊ ，刘瑞新 1， 3， 4 ，王亚旭 ，冯松浩 ，赵丽娜（1. 河南省铁路食品安全管理工程技术研究中心，郑州
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451460；2.河南省天然药物提取和医疗技术应用工程研究中心，郑州 451460；3.河南省中药饮片临床应用现
代化工程研究中心，郑州 450046；4.河南中医药大学第一附属医院药学部，郑州 450046）

中图分类号 R283 文献标志码 A 文章编号 1001-0408（2023）06-0758-05
DOI 10.6039/j.issn.1001-0408.2023.06.22

摘 要 艾叶为菊科植物艾Artemisia argyi Lévl. et Vant.的干燥叶，是我国常用传统中药。笔者通过查阅传统医药古籍、现代标准
规范及文献资料，利用Cytoscape软件对艾叶炮制及炮制品功效的历史沿革进行梳理和可视化呈现。艾叶炮制最早可追溯至汉
代，鼎盛于宋代和明代；古代炮制方法较多，包括净制、切制、炒制、辅料制（醋、酒、盐、制炭、米泔水、硫磺、药汁、枣泥制）和其他制
法（焙制、绞汁、制绒）；现代常用炮制方法包括净制、醋制、制炭和制绒等，与古代炮制方法相比较为单一；生熟艾叶功效及应用差
异明显，虽艾叶古今炮制作用皆以减少毒副作用和增强温经止血等功效为主，但现代药理研究仅见净艾叶、醋艾叶和醋艾炭，其他
炮制品未见延承研究，炮制机制尚不明确。建议在后续探索研究时，研究者可结合药用植物艾的本草特征和中药饮片艾叶的炮制
特色，建立多维度炮制标准研究体系，以系统探索艾叶炮制前后的转化规律，清晰阐述其炮制的科学内涵。
关键词 艾叶；炮制；历史沿革；现代研究；可视化分析

Processing evolution and modern research progress of Artemisia argyi
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ZHANG Xiaoxia 1， 2， 3 ，LIU Ruixin 1， 3， 4 ，WANG Yaxu ，FENG Songhao ，ZHAO Lina（1. Henan Railway Food
Safety Management Engineering Technology Research Center， Zhengzhou 451460， China； 2. Henan Natural
Medicine Extraction and Medical Technology Application Engineering Research Center， Zhengzhou 451460，
China； 3. Henan Provincial Modern Engineering Research Center for Clinical Application of Chinese Herbal
Piece， Zhengzhou 450046， China； 4. Dept. of Pharmacy， the First Affiliated Hospital of Henan University of

Traditional Chinese Medicine， Zhengzhou 450046， China）

ABSTRACT Artemisia argyi is the leaves of compositae plants of A. argyi Lévl. et Vant.， which is a traditional Chinese medicine
commonly used in China. The analysis was carried out by consulting traditional medical classics， modern standard norms and
literature， and using Cytoscape software to sort out and visualize the evolution of the processing and the efficacy of processed
products. The processing of A. argyi was first made in the Han dynasty and was popular in the Song and Ming dynasties. There
were many processing methods in ancient times， including net processing， cutting， frying， processing with auxiliary material
（vinegar， wine， salt， charcoal， rice water， sulfur， medicinal juice， jujube mud processing） and other processing methods
（baking， winching， making herbs into wool）. Modern common processing methods included purification， vinegar processing，
charcoal processing and making herbs into wool， which are relatively simple compared with ancient processing methods. There
were obvious differences in the efficacy and application of raw and processed products of A. argyi. Although the processing effects
of A. argyi in ancient and modern times were mainly to reduce toxic side effects and enhance the effects of warming meridians and
hemostasis， only the purified A. argyi， vinegar-processed A. argyi and vinegar-processed A. argyi charcoal could be seen in the
present studies， other processed products had not been inherited and studied， and the processing mechanism was still unclear. It is
suggested that in the later exploration and research， researchers can establish a multi-dimensional standard research system based on
the characteristics of the medicinal plant A. argyi and the processing characteristics of A. argyi decoction pieces in order to
systematically explore the transformation rules before and after
Δ 基金项目 国家自然科学基金资助项目（No.81773892）；国家中
processing， and clearly explain the scientific connotation.
医药管理局公益性行业专项（No.00104296）；河南省科技攻关项目
（No.222102310359） KEYWORDS Artemisia argyi； processing； historical
＊第一作者 副教授，硕士。研究方向：中药质量控制和分析。电 evolution； modern research； visual analysis
话：0371-60867316。E-mail：zhangxiaoxia@zzrvtc.edu.cn

· 758 · China Pharmacy 2023 Vol. 34 No. 6 中国药房 2023年第34卷第6期