Page 93 - 《中国药房》2023年3期

基于超快速气相电子鼻技术研究中药香囊放置过程中的气味成

分变化
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于小聪 ，张礼欣 ，王泽琨 ，束雅春 ，张先林 ，姚 毅 ，毛春琴（1.南京中医药大学附属医院药学部，南京
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210029；2.南京中医药大学药学院，南京 210023）
中图分类号 R917 文献标志码 A 文章编号 1001-0408（2023）03-0339-06
DOI 10.6039/j.issn.1001-0408.2023.03.16
摘 要 目的 采用超快速气相电子鼻技术，解析不同放置时间下 2 种中药香囊（儿童型和成人型）的气味成分变化规律。方法
通过气相色谱法分析不同放置时间的香囊成分变化规律，同时结合电子鼻自带的Arochembase数据库得出定性结果，并运用判别
因子分析方法分析2种香囊样品的整体气味成分差异。结果 儿童型香囊共鉴定出10种气味成分，其中α-蒎烯和β-蒎烯可作为儿
童型香囊的功能性指标成分；儿童型香囊放置0.25 d后有5种气味成分消失，放置7 d后大部分气味成分基本消失；判别因子分析
累计贡献率为99.225%。成人型香囊共鉴定出8种气味成分，其中α-蒎烯和α-水芹烯可作为成人型香囊的功能性指标成分。成人
型香囊放置0.25 d后有4种气味成分消失；放置15 d后6～8号峰消失，5号峰强度较放置0 d时下降了34.3%；判别因子分析累计贡
献率为91.965%。结论 随着放置时间延长，2种中药香囊的气味成分均在不断减少；建议儿童型香囊的使用时间为7 d，成人型香
囊的使用时间为15 d。
关键词 中药香囊；电子鼻；气相色谱法；气味成分；物质基础

Study on odor composition change of traditional Chinese medicine sachet during placement based on ultra-
fast gasphase electronic nose technology
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YU Xiaocong ，ZHANG Lixin ，WANG Zekun ，SHU Yachun ，ZHANG Xianlin ，YAO Yi ，MAO Chunqin 2
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（1. Dept. of Pharmacy， the Affiliated Hospital of Nanjing University of Chinese Medicine，Nanjing 210029，
China；2. College of Pharmacy， Nanjing University of Chinese Medicine， Nanjing 210023， China）
ABSTRACT OBJECTIVE To analyze the odor composition changes of two kinds of traditional Chinese medicine sachet
（children type and adults type） with different placement time by using ultra-fast gasphase electronic nose technology. METHODS
The change rule of sachet components at different storage times was analyzed by gas chromatography. At the same time， the
qualitative results were obtained by combining electronic nose with Arochembase database. Discriminant factor analysis was used to
analyze the overall odor composition differences of the two sachet samples. RESULTS A total of 10 odor compositions were
identified in children-type sachet， including α-pinene and β-pinene as the functional index compositions； five odor compositions of
children-type sachet disappeared after 0.25 days， and most of them disappeared after 7 days； the cumulative contribution rate of
discriminant factor analysis was 99.225%. A total of 8 odor compositions were identified in adult-type sachets， including α-pinene
and α-phellandrene as the functional index compositions； four odor components disappeared after the adult-type sachet was placed
for 0.25 days； after 15 days of placement， the peak 6-8 disappeared， and the intensity of peak 5 decreased by 34.3% compared
with 0 day of placement； the cumulative contribution rate of discriminant factor analysis was 91.965%. CONCLUSIONS With the
extension of storage time， the smell and composition of the two traditional Chinese medicine sachets are decreasing. It is recommended
that the use time of children-type sachet is 7 days， and that of adult-type sachet is 15 days.
KEYWORDS traditional Chinese medicine sachet； electronic nose； gas chromatography； odor composition； material basis

Δ 基金项目 南京市高价值专利组合项目补助资金资助项目（No. 中药香囊是人类从古至今都在使用的装载有芳香
宁科〔2018〕145号） 类中药的预防与保健用品，现代香囊使用主要是佩戴于
＊第一作者 硕士研究生。研究方向：中药制剂分析与代谢组学。 颈部、腰间、胸前、脚踝，亦可置于枕头内或床帐上 。辟
[1]
E-mail：yu13693868679@163.com
疫香囊可用于预防和治疗疾病，是应用最为广泛、使用
# 通信作者 主任中药师，硕士生导师，博士。研究方向：中医药健 [2―3]
康产品研究与开发。电话：025-86617141。E-mail：guzheng0512@163. 最早的一类中药香囊，也是配方种类最多的一种 。
com 目前有关中药香囊的文献研究主要集中于香囊的药理

中国药房 2023年第34卷第3期 China Pharmacy 2023 Vol. 34 No. 3 · 339 ·