Page 96 - 《中国药房》2023年1期

基于 AHP-TOPSIS 法的阿托西班临床合理用药评价标准的建立

与应用
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殷锦锦 1， 2＊ ，杜培丽 ，谭湘萍 ，梅峥嵘 ，施胜英 ，刘少志 （1.广州医科大学附属第三医院药学部，广州
510150；2. 广东省产科重大疾病重点实验室，广州 510150；3. 广州医科大学附属第三医院产科，广州
510150）
中图分类号 R984 文献标志码 A 文章编号 1001-0408（2023）01-0086-05
DOI 10.6039/j.issn.1001-0408.2023.01.17

摘 要 目的 建立阿托西班的临床合理用药评价标准，为临床合理使用阿托西班提供参考。方法 以醋酸阿托西班注射液说明
书、相关指南为依据，由合理用药评价小组制定合理用药评价标准，包括5个一级指标、8个二级指标。采用层次分析（AHP）法计
算二级指标的权重系数，利用逼近理想值排序（TOPSIS）法对广州医科大学附属第三医院（以下简称“本院”）190例妊娠期妇女使
用醋酸阿托西班注射液的情况进行回顾性评价，根据相对接近度将评价结果分为用药合理、用药基本合理、用药不合理3个层次。
结果 190例妊娠期妇女中，49例（25.8%）为阿托西班用药合理，39例（20.5%）为用药基本合理，102例（53.7%）为用药不合理；AHP-
TOPSIS法所得评价结果与临床实际情况相符。用药不合理的主要问题为超适应证用药、用法用量不合理、超疗程用药及未进行
适宜的经济性考量。结论 通过AHP-TOPSIS法建立了阿托西班临床应用的合理性评价标准，该法所得评价结果可量化、科学可
信。该药在本院的不合理使用现象较为普遍，临床应用时应加强管理。
关键词 阿托西班；合理用药；评价标准；层次分析法；逼近理想值排序法

Establishment and application of evaluation criteria for clinical rational drug use of atosiban based on
AHP-TOPSIS method
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YIN Jinjin ，DU Peili ，TAN Xiangping ，MEI Zhengrong ，SHI Shengying ，LIU Shaozhi （1. Dept. of
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Pharmacy， the Third Affiliated Hospital of Guangzhou Medical University， Guangzhou 510150， China；
2. Guangdong Provincial Key Laboratory of Obstetrics Major Diseases， Guangzhou 510150， China；3. Dept. of
Obstetrics， the Third Affiliated Hospital of Guangzhou Medical University， Guangzhou 510150， China）
ABSTRACT OBJECTIVE To establish evaluation criteria for rational drug use of atosiban in clinic， and to provide reference for
rational drug use of atosiban in clinic. METHODS Based on the drug instructions of atosiban acetate injection and related
guidelines， the experts of the Evaluation Group of Rational Drug Use formulated the evaluation criteria of rational drug use，
including 5 primary indexes and 8 secondary indexes. The weight coefficients of secondary indexes were calculated by analytic
hierarchy process （AHP）， and the use of atosiban acetate injection in 190 pregnant women from the Third Affiliated Hospital of
Guangzhou Medical University （referred to as “our hospital”） was evaluated retrospectively by technique for order preference by
similarity to an ideal solution （TOPSIS）. The evaluation results were divided into three levels including reasonable， basic
reasonable and unreasonable application based on the relative approach degree. RESULTS Among 190 pregnant women， 49
（25.8%） were treated with atosiban reasonably， 39 （20.5%） were treated with atosiban basic reasonably， and 102 （53.7%） were
treated with atosiban unreasonably. The evaluation results obtained by AHP-TOPSIS method were consistent with the actual situation
in clinic. The main problems of the unreasonably use were super indications， unreasonable usage and dosage， over the course of
treatment and the lack of proper economic consideration. CONCLUSIONS The rationality evaluation criteria of atosiban’s clinical
application are established by AHP-TOPSIS method； the evaluation results obtained by this method are quantifiable， scientific and
reliable. The unreasonable use of atosiban is common in our
Δ 基金项目 广东省医学科学技术研究基金项目（No.A2020161，
No.B2018191）；广东省医院药学研究基金项目（No.2016MZ05）；广州 hospital， and the management should be strengthened in
市科技计划项目（No.202201020390） clinical application.
＊第一作者 主管药师，硕士。研究方向：医院药学。电话：020- KEYWORDS atosiban； rational drug use； evaluation criteria；
81292708。E-mail：yinjinjinsunny@163.com
# 通信作者 主管药师，硕士。研究方向：医院药学。电话：020- analytic hierarchy process； technique for order preference by
81298393。E-mail：shaozhiliu@126.com similarity to an ideal solution

· 86 · China Pharmacy 2023 Vol. 34 No. 1 中国药房 2023年第34卷第1期