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基于熵权TOPSIS法综合评价不同产地枇杷叶质量
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          高伟城 ,王小平 ,肖晓琳 ,施义炜 ,林少芬(1.漳州卫生职业学院药学系,福建 漳州 363000;2.福建省漳
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          州市医院药学部,福建 漳州 363000;3.漳州市聚善堂药业有限公司,福建 漳州 363000)
          中图分类号  R917;R282      文献标志码  A      文章编号  1001-0408(2023)01-0072-06
          DOI  10.6039/j.issn.1001-0408.2023.01.14

          摘   要  目的  对不同产地枇杷叶的质量进行综合评价。方法  以不同产地的30份枇杷叶为样品,采用热浸法测定其醇溶性浸出
          物含量,采用紫外分光光度法分别测定其总黄酮含量和总三萜酸含量,采用高效液相色谱法测定其5个三萜酸类成分(野鸦椿酸、
          山楂酸、科罗索酸、齐墩果酸及熊果酸)的含量。采用熵权逼近理想排序法(TOPSIS)综合评价不同产地枇杷叶的质量;运用SPSS
          22.0软件对枇杷叶片重、综合评价值、醇溶性浸出物含量、总黄酮含量、总三萜酸含量及5个三萜酸类成分含量进行双变量相关性
          分析。结果  30 份不同产地枇杷叶中醇溶性浸出物含量为(24.56±0.08)%~(34.85±0.13)%,总黄酮含量为(4.69±0.11)~
         (14.23±0.27) mg/g,总三萜酸含量为(27.58±0.59)~(63.95±1.27) mg/g,野鸦椿酸、山楂酸、科罗索酸、齐墩果酸、熊果酸的含量
          分别为(0.728±0.011)~(6.064±0.063)、(0.526±0.013)~(3.245±0.022)、(1.222±0.025)~(8.807±0.094)、(0.856±0.021)~
         (2.931±0.075)、(4.704±0.087)~(11.806±0.283) mg/g;熵权TOPSIS法分析结果显示,综合评价值排名前3位的样品依次为S14
         (福建漳州云霄县火田镇产)、S19(广西钦州钦南区产)及S29(安徽亳州涡阳县产)。枇杷叶的综合评价值与野鸦椿酸、山楂酸、科
          罗索酸、齐墩果酸和熊果酸这5个三萜酸类成分的含量均呈正相关(P<0.01),且枇杷叶片重与综合评价值呈正相关(P<0.01)。
          结论  不同产地枇杷叶质量存在较大差异,其中以福建漳州云霄县火田镇产、广西钦州钦南区产和安徽亳州涡阳县产枇杷叶的质
          量相对较优;枇杷叶片重与其品质呈正相关。
          关键词  枇杷叶;三萜酸类成分;总黄酮;熵权逼近理想排序法;相关性分析;产地

          Comprehensive evaluation of the quality of Eriobotrya japonica leaves from different producing areas based
          on entropy weight TOPSIS method
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          GAO Weicheng ,WANG Xiaoping ,XIAO Xiaolin ,SHI Yiwei ,LIN Shaofen(1. Dept. of Pharmacy, Zhangzhou
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          Health  Vocational  College,  Fujian  Zhangzhou  363000,  China;2.  Dept.  of  Pharmacy,  Zhangzhou  Municipal
          Hospital  of  Fujian  Province,  Fujian  Zhangzhou  363000,  China;3.  Zhangzhou  Jushantang  Pharmaceutical  Co.,
          Ltd., Fujian Zhangzhou 363000, China)
          ABSTRACT    OBJECTIVE To comprehensively evaluate the quality of Eriobotrya japonica leaves from different producing areas.
          METHODS The contents of alcohol-soluble extracts were determined by hot-dipping method using 30 batches of E. japonica leaves
          from different producing areas as samples. The contents of total flavonoids and total triterpene acids were determined by ultraviolet
          spectrophotometry. The contents of five kinds of triterpenic acids (euscaphic acid,crataegolic acid,corosolic acid,oleanolic acid and
          ursolic  acid)  were  determined  by  HPLC.  The  quality  of  E.  japonica  leaves  from  different  producing  areas  was  comprehensively
          evaluated  by  using  entropy  weight  technique  for  order  preference  by  similarity  to  an  ideal  solution (TOPSIS).  The  bivariate
          correlation  analysis  of  E.  japonica  leaves  was  conducted  by  SPSS  22.0  software  in  terms  of  weight,  comprehensive  evaluation
          value,  the  content  of  alcohol-soluble  extract,  the  contents  of  total  flavonoids,  total  triterpene  acids  and  five  triterpenic  acids.
          RESULTS The contents of alcohol-soluble extract in 30 batches of E. japonica leaves were (24.56±0.08)%-(34.85±0.13)%; the
          contents  of  total  flavonoids  were (4.69±0.11)-(14.23±0.27)  mg/g;  the  contents  of  total  triterpene  acid  were (27.58±0.59)-
         (63.95±1.27) mg/g; the contents of euscaphic acid, crataegolic acid, corosolic acid, oleanolic acid and ursolic acid were (0.728±
          0.011)-(6.064±0.063), (0.526±0.013)-(3.245±0.022), (1.222±0.025)-(8.807±0.094), (0.856±0.021)-(2.931±0.075),
                                                             (4.704±0.087) - (11.806±0.283)  mg/g,  respectively.  The

              Δ 基金项目 全国中药资源普查项目(No.财社〔2019〕39号);漳州            analysis  result  of  entropy  weight  TOPSIS  method  showed  that
          市市级个人科技特派员资助项目(No.20210187);漳州卫生职业学院                the  top  three  samples  with  comprehensive  evaluation  values
          科技创新团队培育计划项目(No.Kjcx-5)                             were  S14  (Huotian  Town,  Yunxiao  County,  Zhangzhou,
             *第一作者 硕士,副教授。研究方向:中药提取分离及质量分析。
          E-mail:280493018@qq.com                             Fujian),  S19 (Qinnan  District,  Qinzhou,  Guangxi)  and  S29
                                                             (Guoyang County, Bozhou, Anhui). Comprehensive evaluation
              # 通信作者 教授,博士。研究方向:中药制剂及质量标准。电话:
          0596-2559522。E-mail:jxrcwxp@163.com                 of  E.  japonica  leaves  was  positively  correlated  with  the


          · 72 ·    China Pharmacy  2023 Vol. 34  No. 1                                中国药房  2023年第34卷第1期
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