Page 120 - 《中国药房》2022年12期
P. 120
fication of genetic variations of the human organic cation Curr Pharm Des,2017,23(17):2532-2550.
transporter hOCT1 and their functional consequences[J]. [33] HE L,WONDISFORD F E. Metformin action:concentra-
Pharmacogenetics,2002,12(8):591-595. tions matter[J]. Cell Metab,2015,21(2):159-162.
[20] ITODA M,SAITO Y,MAEKAWA K,et al. Seven novel [34] XIA L,ENGEL K,ZHOU M Y,et al. Membrane localiza-
single nucleotide polymorphisms in the human SLC22A1 tion and pH-dependent transport of a newly cloned orga-
gene encoding organic cation transporter 1(OCT1)[J]. nic cation transporter(PMAT)in kidney cells[J]. Am J
Drug Metab Pharmacokinet,2004,19(4):308-312. Physiol Renal Physiol,2007,292(2):F682-F690.
[21] BECKER M L,VISSER L E,VAN SCHAIK R H N,et al. [35] BACHMAKOV I,GLAESER H,FROMM M F,et al. In-
Interaction between polymorphisms in the OCT1 and teraction of oral antidiabetic drugs with hepatic uptake
MATE1 transporter and metformin response[J]. Pharmaco- transporters:focus on organic anion transporting polypep-
genet Genomics,2010,20(1):38-44. tides and organic cation transporter 1[J]. Diabetes,2008,
[22] WRÓBEL M P,MAREK B,KAJDANIUK D,et al. Met- 57(6):1463-1469.
formin:a new old drug[J]. Endokrynol Pol,2017,68(4): [36] DING Y,JIA Y Y,SONG Y,et al. The effect of lansopra-
482-496. zole,an OCT inhibitor,on metformin pharmacokinetics in
[23] ITO S,KUSUHARA H,KUROIWA Y,et al. Potent and healthy subjects [J]. Eur J Clin Pharmacol,2014,70(2):
specific inhibition of mMate1-mediated efflux of type Ⅰ 141-146.
organic cations in the liver and kidney by pyrimethamine[J]. [37] NIES A T,HOFMANN U,RESCH C,et al. Proton pump
J Pharmacol Exp Ther,2010,333(1):341-350. inhibitors inhibit metformin uptake by organic cation
[24] STOCKER S L,MORRISSEY K M,YEE S W,et al. The transporters(OCTs)[J]. PLoS One,2011,6(7):e22163.
effect of novel promoter variants in MATE1 and MATE2 [38] KIM A,CHUNG I,YOON S H,et al. Effects of proton
on the pharmacokinetics and pharmacodynamics of met- pump inhibitors on metformin pharmacokinetics and phar-
formin[J]. Clin Pharmacol Ther,2013,93(2):186-194. macodynamics[J]. Drug Metab Dispos,2014,42(7):
[25] CHOI J H,YEE S W,RAMIREZ A H,et al. A common 1174-1179.
5′-UTR variant in MATE2-K is associated with poor [39] STAUD F,CERVENY L,AHMADIMOGHADDAM D,
response to metformin[J]. Clin Pharmacol Ther,2011,90 et al. Multidrug and toxin extrusion proteins(MATE/
(5):674-684. SLC47);role in pharmacokinetics[J]. Int J Biochem Cell
[26] TAKANE H,SHIKATA E,OTSUBO K,et al. Polymor- Biol,2013,45(9):2007-2011.
phism in human organic cation transporters and metfor- [40] MISAKA S,KNOP J,SINGER K,et al. The nonmetabo-
min action[J]. Pharmacogenomics,2008,9(4):415-422. lized β-blocker nadolol is a substrate of OCT1,OCT2,
[27] SONG I S,SHIN H J,SHIM E J,et al. Genetic variants of MATE1,MATE2-K,and P-glycoprotein,but not of
the organic cation transporter 2 influence the disposition OATP1B1 and OATP1B3[J]. Mol Pharm,2016,13(2):
of metformin[J]. Clin Pharmacol Ther,2008,84(5):559- 512-519.
562. [41] SOMOGYI A,STOCKLEY C,KEAL J,et al. Reduction
[28] WANG Z J,YIN O Q P,TOMLINSON B,et al. OCT2 of metformin renal tubular secretion by cimetidine in
polymorphisms and in-vivo renal functional consequence: man[J]. Br J Clin Pharmacol,1987,23(5):545-551.
studies with metformin and cimetidine[J]. Pharmacogenet [42] CHO S K,CHUNG J Y. The MATE1 rs2289669 polymor-
Genomics,2008,18(7):637-645. phism affects the renal clearance of metformin following
[29] 玛依拉·艾则孜.维吾尔族 SLC22A2 多态性及 rs316019 ranitidine treatment[J]. Int J Clin Pharmacol Ther,2016,
突变对二甲双胍药代学、药效学的影响[D].乌鲁木齐:新 54(4):253-262.
疆医科大学,2019. [43] HIBMA J E,ZUR A A,CASTRO R A,et al. The effect of
[30] MOON S J,OH J,LEE S H,et al. Effect of plasma mem- famotidine,a MATE1-selective inhibitor,on the pharma-
brane monoamine transporter genetic variants on pharma- cokinetics and pharmacodynamics of metformin[J]. Clin
cokinetics of metformin in humans[J]. Transl Clin Pharma- Pharmacokinet,2016,55(6):711-721.
col,2018,26(2):79-85. [44] GRÜN B,KIESSLING M K,BURHENNE J,et al. Trime-
[31] CHOI M K,SONG I S. Genetic variants of organic cation thoprim-metformin interaction and its genetic modulation
transporter 1(OCT1)and OCT2 significantly reduce lami- by OCT2 and MATE1 transporters[J]. Br J Clin Pharma-
vudine uptake[J]. Biopharm Drug Dispos,2012,33(3): col,2013,76(5):787-796.
170-178. [45] JAYASAGAR G,KRISHNAKUMAR M,CHANDRASEKHAR
[32] MARKOWICZ-PIASECKA M,HUTTUNEN K M, K,et al. Effect of cephalexin on the pharmacokinetics of
MATEUSIAK L,et al. Is metformin a perfect drug? Up- metformin in healthy human volunteers[J]. Drug Metabol
dates in pharmacokinetics and pharmacodynamics[J]. Drug Interact,2002,19(1):41-48.
·1518 · China Pharmacy 2022 Vol. 33 No. 12 中国药房 2022年第33卷第12期