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综上所述,五味子与补骨脂配伍后可以缓解补骨脂 医学,2020,42(13):1359-1363,1460.
引起的L02肝细胞氧化损伤和内质网应激,这对于防治 [16] WU F L,LIU W Y,VAN POUCKE S,et al. Targeting en-
中药引起的肝损伤具有一定参考价值。但由于氧化应 doplasmic Reticulum stress in liver disease[J]. Expert Rev
激和内质网应激的机制非常复杂,在后续的研究中还需 Gastroenterol Hepatol,2016,10(9):1041-1052.
进一步完善。 [17] 李艳,曹美群,陶文聪,等.黄芪散对高脂饮食诱导肥胖大
参考文献 鼠肝脏内质网应激信号通路的影响[J].中国实验方剂学
杂志,2019,25(21):6-11.
[ 1 ] CHO J H,OH D S,HONG S H,et al. A nationwide study
[18] 陈圻,黄文海,沈正荣,等.上皮-间质转化在肺纤维化中的
of the incidence rate of herb-induced liver injury in
Korea[J]. Arch Toxicol,2017,91(12):4009-4015. 研究进展[J].中国现代应用药学,2019,36(9):1155-1160.
[ 2 ] 赵子婧,巩政,史少泽,等.补骨脂及其与甘草配伍单次给 [19] 高晓乐,段冷昕,仇可可,等.鬼针草水煎液对高脂高糖诱
药大鼠的毒代动力学及肝肾毒性初探[J].中国中药杂 导的小鼠非酒精性脂肪肝的作用及机制研究[J].中国中
志,2015,40(11):2221-2226. 药杂志,2020,45(16):3915-3921.
[ 3 ] 朱春雾,王海南,张亚蕾,等.仙灵骨葆胶囊导致肝损伤[J]. [20] 刘欣盈,陆文清,沈昕昕,等. SIRT3在白血病耐药中作用
肝脏,2018,23(12):1090-1093. 的研究进展[J].上海交通大学学报(医学版),2019,39
[ 4 ] CHEUNG W I,TSE M L,NGAN T,et al. Liver injury as- (3):331-335.
sociated with the use of Fructus Psoraleae(Bol-gol-zhee [21] KANG J,JIA Z H,PING Y,et al. Testosterone alleviates
or Bu-gu-Zhi)and its related proprietary medicine[J]. Clin mitochondrial ROS accumulation and mitochondria-
Toxicol(Phila),2009,47(7):683-685. mediated apoptosis in the gastric mucosa of orchiectomized
[ 5 ] 国家药典委员会.中华人民共和国药典:一部[S]. 2020年 rats[J]. Arch Biochem Biophys,2018,649:53-59.
版.北京:中国医药科技出版社,2020:68. [22] BHATTI J S,BHATTI G K,REDDY P H. Mitochondrial
[ 6 ] 郭文鹤,李晓宇,黄娜娜,等.基于中药性味理论的补骨脂 dysfunction and oxidative stress in metabolic disorders:a
配伍规律研究进展[J].中国药物警戒,2017,14(12): step towards mitochondria based therapeutic strategies[J].
737-741. Biochim Biophys Acta Mol Basis Dis,2017,1863(5):
[ 7 ] 王敏.补骨脂二氢黄酮甲醚对肝脏毒性作用及机制研究 1066-1077.
[D].哈尔滨:哈尔滨商业大学,2018. [23] FREDRIKSSON L,WINK S,HERPERS B,et al. Drug-
[ 8 ] YU Y L,YU R L,MEN W J,et al. Psoralen induces hepa- induced endoplasmic Reticulum and oxidative stress
tic toxicity through PERK and ATF6 related ER stress responses independently sensitize toward TNFα-mediated
pathways in HepG2 cells[J].Toxicol Mech Methods,2020, hepatotoxicity[J]. Toxicol Sci,2014,140(1):144-159.
30(1):39-47. [24] IORGA A,DARA L,KAPLOWITZ N. Drug-induced
[ 9 ] YANG Y,TANG X L,HAO F R,et al. Bavachin induces liver injury:cascade of events leading to cell death,apop-
apoptosis through mitochondrial regulated ER stress path- tosis or necrosis[J]. Int J Mol Sci,2017,18(5):1018.
way in HepG2 cells[J]. Biol Pharm Bull,2018,41(2): [25] MANDL J,MÉSZÁROS T,BÁNHEGYI G,et al. Minire-
198-207. view:endoplasmic Reticulum stress:control in protein,
[10] 于泓洋,宋远航,赵亮,等.内质网应激与酒精性肝病研究 lipid,and signal homeostasis[J]. Mol Endocrinol,2013,27
进展[J].化工时刊,2021,35(10):32-36. (3):384-393.
[11] GÖRLACH A,BERTRAM K,HUDECOVA S,et al. Cal- [26] YU R L,YU Y L,SU S J,et al. Psoralen induces liver
cium and ROS:a mutual interplay[J]. Redox Biol,2015, injuries through endoplasmic Reticulum stress signaling in
6:260-271. female mice[J]. Drug Chem Toxicol,2021:1-7.
[12] PLAISANCE V,BRAJKOVIC S,TENENBAUM M,et al. [27] LUO C L,XIONG H X,CHEN L F,et al. GRP78 Pro-
Endoplasmic Reticulum stress links oxidative stress to motes Hepatocellular Carcinoma proliferation by increa-
impaired pancreatic beta-cell function caused by human sing FAT10 expression through the NF-κ B pathway[J].
oxidized LDL[J]. PLoS One,2016,11(9):e0163046.
Exp Cell Res,2018,365(1):1-11.
[13] WANG R,QI X S,YOSHIDA E M,et al. Clinical charac-
[28] 杨顺,袁盾,刘松林,等.内质网应激/未折叠蛋白反应在
teristics and outcomes of traditional Chinese medicine-
抑制脑胶质母细胞瘤中的研究进展[J].国际神经病学神
induced liver injury:a systematic review[J]. Expert Rev
经外科学杂志,2021,48(3):284-288.
Gastroenterol Hepatol,2018,12(4):425-434.
[29] 刘霞,王艳,江华维,等.内质网应激在年龄相关性黄斑变
[14] 杨阔,高茸,马亚中,等.补骨脂素药理作用及肝毒性机制
性中的研究进展[J].国际眼科杂志,2022,22(2):244-248.
的研究进展[J].中草药,2021,52(1):289-298.
(收稿日期:2022-01-05 修回日期:2022-03-24)
[15] 谢一潋,褚金国,杨乃彬,等.姜黄素对脂多糖/D-氨基半
(编辑:林 静)
乳糖诱导大鼠急性肝损伤中内质网应激的影响[J].浙江
中国药房 2022年第33卷第9期 China Pharmacy 2022 Vol. 33 No. 9 ·1093 ·