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死肿瘤细胞也是没食子醇提物的抗癌机制之一。                                   瘤学杂志,2021,3(4):1-11.
            综上所述,没食子醇提物能够增加结肠癌细胞中                          [14]  魏秋红,刘晓月,王盼,等. 抗肿瘤药物的分类和药效学
        ROS的积累,降低炎症微环境中IL-6、TNF-α等炎症因子                          研究进展[J].医学综述,2020,26(18):3707-3711,3716.
        的 表 达 ,同 时 降 低 JAK2/STAT3 信 号 通 路 中 JAK2、          [15]  李萍,刘馨,刘洪璐,等.癌相关性炎症因子IL-6在肿瘤微
        STAT3蛋白的磷酸化水平,进而下调Bcl-2蛋白表达、上                           环境中的作用研究进展[J].现代肿瘤医学,2017,25
                                                                (19):3174-3177.
        调Bax蛋白表达,最后达到抑制结肠癌的效果。本研究
                                                           [16]  郭芳.蒽醌类衍生物 C10 通过 Jak/Stat3 信号通路对结肠
        结果为阐明没食子抗结肠癌的作用机制提供了实验基
                                                                癌细胞增殖的影响[D].太原:山西大学,2020.
        础,但仍需后续进行更加深入的机制研究。
                                                           [17]  BROMBERG J F,WRZESZCZYNSKA M H,DEVGAN G,
        参考文献                                                    et al. Stat3 as an oncogene[J]. Cell,1999,98(3):295-303.
        [ 1 ]  ESLAMI M,YOUSEFI B,KOKHAEI P,et al. Importance  [18]  LING X Y,ARLINGHAUS R B. Knockdown of STAT3
             of probiotics in the prevention and treatment of colorectal  expression by RNA interference inhibits the induction of
             cancer[J]. J Cell Physiol,2019,234(10):17127-17143.  breast tumors in immunocompetent mice[J]. Cancer Res,
        [ 2 ]  SUNG H,FERLAY J,SIEGEL R L,et al. Global cancer  2005,65(7):2532-2536.
             statistics 2020:GLOBOCAN estimates of incidence and  [19]  O’SHEA J J,SCHWARTZ D M,VILLARINO A V,et al.
             mortality worldwide for 36 cancers in 185 countries[J].  The JAK-STAT pathway:impact on human disease and
             CA Cancer J Clin,2021,71(3):209-249.               therapeutic intervention[J]. Annu Rev Med,2015,66:
        [ 3 ]  PIAWAH S,VENOOK A P. Targeted therapy for colorec-  311-328.
             tal cancer metastases:a review of current methods of mo-  [20]  JOHNSON D E,O'KEEFE R A,GRANDIS J R. Targeting
             lecularly targeted therapy and the use of tumor biomarkers  the IL-6/JAK/STAT3 signalling axis in cancer[J]. Nat Rev
             in the treatment of metastatic colorectal cancer[J]. Cancer,  Clin Oncol,2018,15(4):234-248.
             2019,125(23):4139-4147.                       [21]  O’SHEA J J,PLENGE R. JAK and STAT signaling mole-
        [ 4 ]  闫珺,石婷婷,刘松江.刘松江教授治疗结肠癌经验浅                         cules in immunoregulation and immune-mediated disease
             谈[J].现代肿瘤医学,2019,27(3):486-488.                    [J]. Immunity,2012,36(4):542-550.
        [ 5 ]  KOSTIC A D,CHUN E,MEYERSON M,et al. Microbes  [22]  LIANG Q,XIAO Y Y,LIU K H,et al. Cr(Ⅵ)-induced au-
             and inflammation in colorectal cancer[J].Cancer Immunol  tophagy protects L-02 hepatocytes from apoptosis through
             Res,2013,1(3):150-157.                             the ROS-AKT-mTOR pathway[J]. Cell Physiol Biochem,
        [ 6 ]  WANG D,DUBOIS R N. The role of COX-2 in intestinal  2018,51(4):1863-1878.
             inflammation and colorectal cancer[J].Oncogene,2010,29  [23]  ZHANG C T,HUANG C C,YANG P P,et al. Eldecalcitol
            (6):781-788.                                        induces apoptosis and autophagy in human osteosarcoma
        [ 7 ]  ELHAM A,ARKEN M,KALIMANJAN G,et al. A re-        MG-63 cells by accumulating ROS to suppress the PI3K/
             view of the phytochemical,pharmacological,pharmacoki-  Akt/mTOR signaling pathway[J]. Cell Signal,2021,78:
             netic,and toxicological evaluation of Quercus Infectoria  109841.
             galls[J]. J Ethnopharmacol,2021,273:113592.   [24]  ZHU S S,ZHOU J,SUN X Y,et al. ROS accumulation
        [ 8 ]  NIMRI L F,MEQDAM M M,ALKOFAHI A. Antibacterial   contributes to abamectin-induced apoptosis and autopha-
             activity of Jordanian medicinal plants[J]. Pharm Biol,  gy via the inactivation of PI3K/AKT/mTOR pathway in
             1999,37(3):196-201.                                TM3 Leydig cells[J]. J Biochem Mol Toxicol,2020,34
        [ 9 ]  美热古丽·依米提.基于 IL-6/JAK/STAT3 信号通路研究                (8):e22505.
             没食子提取物抗溃疡性结肠炎的作用机制[D].乌鲁木                     [25]  ZHANG Z H,LI M Y,WANG Z,et al. Convallatoxin pro-
             齐:新疆医科大学,2018.                                     motes apoptosis and inhibits proliferation and angiogene-
        [10]  孔令豪,潘传芳,沈克平. JAK/STAT 信号通路与大肠癌                    sis through crosstalk between JAK2/STAT3(T705)and
             及中医药调控[J].中医药临床杂志,2019,31(4):785-                  mTOR/STAT3 (S727) signaling pathways in colorectal
             788.                                               cancer[J]. Phytomedicine,2020,68:153172.
        [11]  ZIN N N I N M,MOHAMAD M N,ROSLAN K,et al. In  [26]  XU G Y,TANG X J. Troxerutin(TXN)potentiated 5-fluo-
             vitro antimalarial and toxicological activities of Quercus  rouracil(5-Fu)treatment of human gastric cancer through
             infectoria(Olivier)gall extracts[J]. Malays J Med Sci,  suppressing STAT3/NF-κB and Bcl-2 signaling pathways
             2020,27(4):36-50.                                  [J]. Biomed Pharmacother,2017,92:95-107.
        [12]  徐月,李沅洋,齐新,等. 5-氟尿嘧啶心脏毒性的研究进                                 (收稿日期:2021-10-08  修回日期:2021-12-21)
             展与中药防治[J].天津中医药,2021,38(5):671-675.                                                (编辑:林 静)
        [13]  毕启瑞,李运,高敏,等.抗肿瘤中药研究进展[J].中医肿





        中国药房    2022年第33卷第3期                                               China Pharmacy 2022 Vol. 33 No. 3  ·331 ·
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