Page 121 - 2021年14期
P. 121
2018,38(4):639-654. set of effect and impact on health-related quality of life,
[ 8 ] TAN L D,BRATT J M,GODOR D,et al. Benralizumab:a exacerbation rate,lung function,and nasal polyposis
unique IL-5 inhibitor for severe asthma[J]. J Asthma symptoms for patients with severe eosinophilic asthma
Allergy,2016,9(4):71-81. treated with benralizumab(ANDHI):a randomised,con-
[ 9 ] LAVIOLETTE M,GOSSAGE D L,GAUVREAU G,et al. trolled,phase 3b trial[J]. Lancet Respir Med,2021,9(3):
Effects of benralizumab on airway eosinophils in asthma- 260-274.
tic patients with sputum eosinophilia[J]. J Allergy Clin [19] CHUNG K F,WENZEL S E,BROZEK J L,et al. Interna-
Immunol,2013,132(5):1086-1096. tional ERS/ATS guidelines on definition,evaluation and
[10] CASTRO M,WENZEL S E,BLEECKER E R,et al. Ben- treatment of severe asthma[J]. Eur Respir J,2014,43(2):
ralizumab,an anti-interleukin 5 receptor α monoclonal an- 343-373.
tibody,versus placebo for uncontrolled eosinophilic asth- [20] HAYASHINO Y,NOGUCHI Y,FUKUI T. Systematic
ma:a phase 2b randomised dose-ranging study[J]. Lancet evaluation and comparison of statistical tests for publica-
Respir Med,2014,2(11):879-890. tion bias[J]. J Epidemiol,2005,15(6):235-243.
[11] NOWAK R M,PARKER J M,SILVERMAN R A,et al. [21] KASSA G M. Mother-to-child transmission of HIV infec-
Arandomized trial of benralizumab,an antiinterleukin 5 tion and its associated factors in Ethiopia:a systematic re-
receptor α monoclonal antibody,after acute asthma[J]. view and meta-analysis[J]. BMC Infect Dis,2018,18(1):
Am J Emerg Med,2015,33(1):14-20. 1-9.
[22] 王吉耀.循证医学与临床实践[M]. 4 版.北京:科学出版
[12] PARK H S,KIM M K,IMAI N,et al. A phase 2a study of
社,2019:122.
benralizumab for patients with eosinophilic asthma in
[23] WANG B,YAN L,HUTMACHER M,et al. Exposure-re-
South Korea and Japan[J]. Int Arch Allergy Immunol,
sponse analysis for determination of benralizumab optimal
2016,169(3):135-45.
dosing regimen in adults with asthma[J]. Am J Respir Crit
[13] FITZGERALD J M,BLEECKER E R,NAIR P,et al. Ben-
Care Med,2014,189(9):A1324.
ralizumab,an anti-interleukin-5 receptor α monoclonal an-
[24] PAPI A,BLASI F,CANONICA G W,et al. Treatment
tibody,as add-on treatment for patients with severe,un-
strategies for asthma:reshaping the concept of asthma
controlled,eosinophilic asthma (CALIMA) :a ran-
management[J]. Allergy Asthma ClinImmunol,2020,16
domised,double-blind,placebo-controlled phase 3 trial[J].
(3):75-85.
Lancet,2016,388(10056):2128-2141.
[25] KITCH B T,PALTIEL A D,KUNTZ K M,et al. A single
[14] BLEECKER E R,FITZGERALD J M,CHANEZ P,et al.
measure of FEV1 is associated with risk of asthma attacks
Efficacy and safety of benralizumab for patients with se-
in long-term follow-up[J]. Chest,2004,126(6):1875-
vere asthma uncontrolled with high-dosage inhaled corti-
1882.
costeroids and long-acting β 2-agonists(SIROCCO):a ran-
[26] JUNIPER E F,SVENSSON K,MORK A C,et al. Mea-
domised,multicentre,placebo-controlled phase 3 trial[J].
surement properties and interpretation of three shortened
Lancet,2016,388(10056):2115-2127.
versions of the asthma control questionnaire[J]. Respir
[15] NAIR P,WENZEL S,RABE K F,et al. Oral glucocorti-
Med,2005,99(5):553-558.
coid-sparing effect of benralizumab in severe asthma[J].
[27] 齐军,吴倩,李森,等.哮喘控制问卷与哮喘生命质量问卷
N Engl J Med,2017,376(25):2448-2458.
在哮喘患者中的应用价值研究[J].国际呼吸杂志,2014,
[16] FERGUSON G T,FITZGERALD J M,BLEECKER E R, 34(3):174-176.
et al. Benralizumab for patients with mild to moderate,
[28] TIAN B P,ZHANG G S,LOU J,et al. Efficacy and safety
persistent asthma(BISE):a randomised,double-blind,pla- of benralizumab for eosinophilic asthma:a systematic re-
cebo-controlled,phase 3 trial[J]. Lancet Respir Med, view and meta-analysis of randomized controlled trials[J].
2017,5(7):568-576. J Asthma,2018,55(9):956-965.
[17] PANETTIERI R A,Jr,WELTE T,SHENOY K V,et al. [29] BUSSE W W,BLEECKER E R,FITZGERALD J M,et al.
Onset of effect,changes in airflow obstruction and lung Long-term safety and efficacy of benralizumab in patients
volume,and health-related quality of life improvements with severe,uncontrolled asthma:1-year results from the
with benralizumab for patients with severe eosinophilic BORA phase 3 extension trial[J]. Lancet Respir Med,
asthma:phase Ⅲb randomized,controlled trial(SOLANA) 2019,7(1):46-59.
[J]. J Asthma Allergy,2020,13(2):115-126. (收稿日期:2021-02-01 修回日期:2021-05-15)
[18] HARRISON T W,CHANEZ P,MENZELLA F,et al. On- (编辑:林 静)
中国药房 2021年第32卷第14期 China Pharmacy 2021 Vol. 32 No. 14 ·1775 ·