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·药物与临床·

改良复方聚乙二醇电解质散肠道准备方法在便秘患者肠镜检查

中的应用 Δ

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赵 兵 ，吴至久，唐学贵 ，孔鹏飞，陈泰宇，刘仕鸿（川北医学院附属医院肛肠科，四川 南充 637000）
中图分类号 R977.7；R442.2 文献标志码 A 文章编号 1001-0408（2021）13-1607-04
DOI 10.6039/j.issn.1001-0408.2021.13.12
摘 要 目的：探讨改良复方聚乙二醇电解质散（SF-PEG）肠道准备方法在便秘患者肠镜检查中的应用效果及安全性。方法：将
2020 年 1－8 月在川北医学院附属医院肛肠科拟行肠镜检查的便秘患者共 160 例按照随机数字表法分为观察组和对照组，各 80
例。对照组患者在检查当日凌晨3：00口服SF-PEG 2盒（兑入温水3 000 mL中），2 h内服完。观察组患者在检查前一晚20：00和
检查当日清晨5：00分别口服SF-PEG 1盒（兑入温水1 500 mL中），1 h内喝完；并于检查当日清晨7：00口服二甲硅油散1瓶（兑入
温水75 mL中）。比较两组患者的肠道准备满意度、肠道气泡评分、肠镜检查操作时间、息肉检出情况、患者耐受率和再次肠道准
备接受率及不良反应发生情况。结果：两组患者均顺利完成肠道准备及肠镜检查。观察组患者的肠道准备总满意率、肠道气泡满
意率、息肉检出率、患者耐受率和再次肠道准备接受率均显著高于对照组（P＜0.05），恶心呕吐的发生率和不良反应总发生率显著
低于对照组（P＜0.05），肠镜检查操作时间显著短于对照组（P＜0.05）。结论：应用分次口服SF-PEG联合二甲硅油散的方法对便
秘患者做肠镜检查前的肠道准备，具有肠道准备满意度高、肠道气泡少、检查操作时间短、息肉检出率高、患者耐受率和再次肠道
准备接受率高、不良反应少等优点，是一种安全有效的肠道准备方法。
关键词 复方聚乙二醇电解质散；二甲硅油散；便秘；肠镜检查；肠道准备

Application of Modified Preparation Method of Compound Polyethylene Glycol Electrolyte Powder in
Colonoscopy for Patients with Constipation
ZHAO Bing，WU Zhijiu，TANG Xuegui，KONG Pengfei，CHEN Taiyu，LIU Shihong（Dept. of Anorectal，the
Affiliated Hospital of North Sichuan Medical College，Sichuan Nanchong 637000，China）

ABSTRACT OBJECTIVE：To investigate the application effect and safety of modified compound polyethylene glycol electrolyte
powder（SF-PEG）in intestinal preparation method for patients with constipation undergoing colonoscopy. METHODS：From Jan.
2020 to Aug. 2020，160 patients with constipation undergoing colonoscopy in anorectal department of the affiliated hospital of
North Sichuan Medical College were randomly divided into observation group and control group，with 80 cases in each group. The
patients in the control group took 2 boxes of SF-PEG（mixed into 3 000 mL warm water）orally at 3：00 a.m. on the day of
examination，and finished within 2 hours. The patients in the observation group took 1 box of SF-PEG（mixed into 1 500 mL warm
water）at 20：00 the night before the examination and 5：00 in the morning of the day of examination，and drank it within 1 hour；1
bottle of Dimethylsiloxane powder（mixed into 75 mL warm water）was taken orally at 7：00 a.m. on the inspection day. The
satisfaction of intestinal preparation，intestinal bubble score，operation time of colonoscopy，detection of polyps，tolerance rate，
acceptance rate of repeating intestinal preparation of patients and incidence of adverse reactions were compared between the two
groups. RESULTS：The patients of 2 groups successfully completed bowel preparation and colonoscopy. The intestinal preparation
total satisfaction rate，intestinal bubble satisfaction rate，polyp detection rate，tolerance rate and repeating intestinal preparation
acceptance rate of patients of observation group were significantly higher than control group（P＜0.05），while the incidence of
nausea and vomiting and total incidence of adverse reactions were significantly lower than control group （P＜0.05），and the
operation time of colonoscopy was significantly shorter than control group（P＜0.05）. CONCLUSIONS：Oral administration of
SF-PEG in batches combined with Dimethylsiloxane powder for bowel preparation in patients with constipation before colonoscopy
have the advantages of high satisfaction with bowel preparation，less intestinal bubbles，short operation time，high detection rate of
polyps，high tolerance rate of patients，high acceptance rate of repeating intestinal preparation and less adverse reactions. It is a
safe and effect method for intestinal preparation.
KEYWORDS Compound polyethylene glycol electrolyte powder；Dimethylsiloxane powder；Constipation；Colonoscopy；Intestinal
preparation

Δ 基金项目：国家自然科学基金资助项目（No.81573990）
电子肠镜检查是目前结直肠疾病诊断和治疗最常
＊讲师，硕士。研究方向：肛肠疾病的中西医结合治疗。E-mail：
用的方法之一，在结直肠病变的筛查中起着重要作用。
zhaobing1261015@126.com
# 通信作者：教授，博士。研究方向：肛肠疾病的中西医结合治 然而，如果患者肠道准备不充分，肠腔内残留较多粪水，
疗。E-mail：txg668nc@sohu.com 就会影响到肠镜操作视野，增加检查难度，延长操作时

中国药房 2021年第32卷第13期 China Pharmacy 2021 Vol. 32 No. 13 ·1607 ·