Page 49 - 《中国药房》2021年2期

含杜仲古今方剂的对比研究 Δ

1 #
2
唐利东 ，王健英 ，袁 颖 （1.上海中医药大学中药学院，上海 201203；2.上海中医药大学协同创新中心，上
1＊
海 201203）
中图分类号 R289 文献标志码 A 文章编号 1001-0408（2021）02-0171-06
DOI 10.6039/j.issn.1001-0408.2021.02.08

摘 要 目的：对比含杜仲古今方剂配伍药材的性味归经及配伍规律，为杜仲的现代临床应用提供理论依据。方法：检索《中医方
剂大词典》筛选含杜仲的古代方剂；在中国知网、万方数据、维普网中检索2000年1月至2020年1月发表的现代临床研究中含杜仲
的方剂。采用频次统计、Apriori算法等数据挖掘方法，对含杜仲古今方剂的主治疾病和涉及药材的使用频次、种类、性味归经及配
伍规律进行分析。结果：共纳入含杜仲古方84首、今方188首。古方主要用于治疗腰痛、虚病、胎动不安等疾病；今方主要用于治
疗骨关节病（以腰椎间盘突出症为主）、妇产科疾病、心脑血管疾病等。古方中与杜仲配伍的高频药材为肉桂、当归、牛膝等，大多
为补虚药、祛风湿药、清热药；配伍药材药性以温热性为主，归经多为肾、肝经，药味以甘、辛味为主。今方中与杜仲配伍的高频药
材为当归、甘草、熟地黄等，大多为补虚药、祛风湿药、活血化瘀药；配伍药材药性以温热性为主，归经多为肝、肾经，药味以苦、辛味
为主。对高频药材进行的Apriori关联规则分析结果显示，古方共获得核心药材组合10条，包含8个三阶关联规则、2个四阶关联
规则；今方共获得核心药材组合11条，包含3个三阶关联规则、8个四阶关联规则。结论：含杜仲的古今方剂均主要用于治疗腰部
疾病，其次为妇产科疾病，此外，今方还可用于治疗心脑血管疾病。古方主要以温补为主，而今方在补虚的基础上更多地配伍了祛
风湿药和活血化瘀药；古方的配伍药材多归肾、肝经，以甘、辛味为主，今方的配伍药材多归肝经，且更多地配伍了苦味药材。
关键词 杜仲；古方；今方；Apriori算法；配伍规律

Comparative Study on Ancient and Modern Prescriptions Containing Eucommia ulmoides
1
1
TANG Lidong ，WANG Jianying ，YUAN Ying （1.School of Chinese Medicine， Shanghai University of
2
Traditional Chinese Medicine， Shanghai 201203， China； 2. Collaborative Innovation Center， Shanghai
University of Traditional Chinese Medicine，Shanghai 201203，China）
ABSTRACT OBJECTIVE：To compare the meridian tropism of compatible herbs and compatibility rules of ancient and modern
prescriptions containing Eucommia ulmoides，and to provide theoretical basis for modern clinical application of E. ulmoides.
METHODS：Ancient prescriptions containing E. ulmoides were screened from Dictionary of TCM Prescription. The prescriptions
containing E. ulmoides were screened from clinical trials which published in CNKI，Wanfang database and VIP during Jan. 2000 to
Jan. 2020. Data mining methods such as frequency statistics and Apriori algorithm were used to analyze the main diseases of ancient
and modern prescriptions containing E. ulmoides and the use frequency，types，meridian tropism and compatibility rules of medical
materials. RESULTS：A total of 84 ancient prescriptions and 188 modern prescriptions of E. ulmoides were included. Ancient
prescriptions were mainly used to treat diseases such as back pain，deficiency，threatened abortion. Modern prescriptions were
mainly used to treat osteoarthropathy （mainly lumbar intervertebral disc herniation）， gynecological diseases，cardiovascular
diseases. Cinnamomum cassia，Angelica sinensis and Achyranthes bidentatawerethe were the high-frequency compatible herbs in
ancient prescriptions with E. ulmoides，and were tonifying medicine，dispelling wind and dampness medicine and clearing heat
medicine；compatible herbs were mainly of warm property，and the channel tropism was mostly kidney meridian and liver
meridian；the five tastes of compatible herbs were mainly sweet and spicy. A. sinensis，Glycyrrhiza uralensis and Rehmanniae
Radix Praeparata were the high-frequency compatible herbs in modern prescriptions with E. ulmoides，and were mainly tonic
medicine，anti-rheumatic medicine，medicine for promoting blood circulation and removing blood stasis；compatible herbs were
mainly of warm property，and the channel tropism was mostly liver meridian and kidney meridian；the five tastes of medicine were
mainly bitter and spicy. By analyzing the Apriori association rules of high-frequency herbs，a total of 10 core herbs combinations
were obtained in ancient prescriptions，including 8 third-order association rules and 2 fourth-order association rules；a total of 11
core herbs combinations were obtained in modern prescriptions，including 3 third-order association rules and 8 fourth-order
association rules. CONCLUSIONS： Ancient and modern
Δ 基金项目：国家自然科学基金资助项目（No.81773922）；上海市
prescriptions containing E. ulmoidesare mainly used to treat
科研计划项目（No.19ZR1452000）
lumbar disease， followed by obstetrics and gynecology
＊硕士研究生。研究方向：中药学。E-mail：t1569495912@163.
com diseases. In addition，the modern prescriptions can also be
# 通信作者：副教授，硕士生导师，博士。研究方向：中药及复方 used for the treatment of cardiovascular and cerebrovascular
药效作用机制。E-mail：yyin921@163.com diseases. The ancient prescriptions mainly focus on warming

中国药房 2021年第32卷第2期 China Pharmacy 2021 Vol. 32 No. 2 ·171 ·