Page 58 - 202013
P. 58

著 降 低 脊 髓 背 角 内 Iba-1、p-p38MAPK、IL-6、IL-1 β 、            BAM8-22  inhibiting  microglia  activation: represses
        TNF-α蛋白的表达水平。                                            CX3CR1 expression via upregulating miR-184[J]. J Mol
            综上所述,鞘内给予 8-OaS 可有效缓解大鼠慢性炎                           Neurosci,2019. DOI:10.1007/s12031-019-01455-0.
        性痛,其机制可能与抑制 p38 MAPK 磷酸化和 IL-6、IL-                  [10]  YAZDZNI J,KHIAVI RK,GHAVIMI MA,et al. Calcito-
        1β、TNF-α的表达有关。                                           nin as an analgesic agent:review of mechanisms of action
                                                                 and clinical applications[J]. Rev Bras Anestesiol,2019.
        参考文献
                                                                 DOI:10.1016/j.bjan.2019.08.004.
        [ 1 ]  TURUNEN A,KUULIALA A,PENTTILA A,et al. Time
                                                            [11]  HE JH,YU L,WANG ZY,et al. Inhibition of monocar-
             course of signaling profiles of blood leukocytes in acute
                                                                 boxylate transporter 1 in spinal cord horn significantly re-
             pancreatitis and sepsis[J]. Scand J Clin Lab Invest,2020,
                                                                 verses chronic inflammatory pain[J]. J Pain Res,2019,12
             80(2):114-123.
                                                                (5):2981-2990.
        [ 2 ]  MCWILLIAMS DF,RAHMAN S,JAMES RJE,et al.
                                                            [12]  SHINODA M,KUBO A,HAYASHI Y,et al. Peripheral
             Disease activity flares and pain flares in an early rheuma-
                                                                 and central mechanisms of persistent orofacial pain [J].
             toid arthritis inception cohort;characteristics,antecedents
                                                                 Front Neurosci,2019. DOI:10.3389/fnins.2019.01227.
             and sequelae[J]. BMC Rheumatol,2019. DOI:10.1186/
                                                            [13]  DU HX,CHEN XG,ZHANG L,et al. Microglial activa-
             s41927-019-0100-9.
                                                                 tion and neurobiological alterations in experimental auto-
        [ 3 ]  BARROS LL,FARIAS AQ,REZAIE A. Gastrointestinal
                                                                 immune prostatitis-induced depressive-like behavior in
             motility and absorptive disorders in patients with inflam-
                                                                 mice[J]. Neuropsychiatr Dis Treat,2019,15(6):2231-
             matory bowel diseases:prevalence,diagnosis and treat-
                                                                 2245.
             ment[J]. World J Gastroenterol,2019,25(31):4414-
                                                            [14]  QIN B,LI Y,LIU X,et al. Notch activation enhances mi-
             4426.
                                                                 croglial CX3CR1/P38 MAPK pathway in rats model of
        [ 4 ]  EIDSON LN,MURPHY AZ. Inflammatory mediators of
                                                                 vincristine-induced peripheral neuropathy[J]. Neurosci
             opioid tolerance:implications for dependency and addic-
                                                                 Lett,2019. DOI:10.1016/j.neulet.2019.134624.
             tion[J]. Peptides,2019. DOI:10.1016/j.peptides.2019.01.
                                                            [15]  PAIGE C,MARUTHY GB,MEJIA G,et al. Spinal inhibi-
             003.
                                                                 tion of P2XR or p38 signaling disrupts hyperalgesic prim-
        [ 5 ]  WANG J,QIAO Y,YANG RS,et al. The synergistic ef-
                                                                 ing in male,but not female,mice[J]. Neuroscience,2018,
             fect of treatment with triptolide and MK-801 in the rat
                                                                 385(10):133-142.
             neuropathic pain model[J]. Mol Pain,2017. DOI:10.1177/
                                                            [16]  FUJITA M,TAMANO R,YONEDA S,et al. Ibudilast pro-
             1744806917746564.
                                                                 duces anti-allodynic effects at the persistent phase of pe-
        [ 6 ]  王健,肖小莉,崔佳,等. 8-O-乙酰山栀子苷甲酸对慢性
                                                                 ripheral or central neuropathic pain in rats:different inhibi-
             炎性痛模型大鼠脊髓背角内 HDAC1~5 表达的影响及
                                                                 tory mechanism on spinal microglia from minocycline
             与 JAK2-STAT3 信号通路的关系研究[J].中国药房,
                                                                 and propentofylline[J]. Eur J Pharmacol,2018,833(15):
             2019,30(5):38-43.
                                                                 263-274.
        [ 7 ]  ZHANG W,BAI Y,QIAO Y,et al. 8-O-acetyl shanzhi-
                                                            [17]  CHENG H,ZHANG Y,LU W,et al. Caffeic acid pheneth-
             side methylester from lamiophlomis rotata reduces neuro-
                                                                 yl ester attenuates neuropathic pain by suppressing the
             pathic pain by inhibiting the ERK/TNF-α pathway in spi-
                                                                 p38/NF-κ B signal pathway in microglia[J]. J Pain Res,
             nal astrocytes[J]. Front Cell Neurosci,2018. DOI:10.
                                                                 2018,11(1):2709-2719.
             3389/fncel.2018.00054.
                                                            [18]  JIN GL,HE SD,LIN SM,et al. Koumine attenuates neuro-
        [ 8 ]  SHUAI S,HUAN X,MIN H,et al. Isotalatizidine,a C19-
                                                                 glia activation and inflammatory response to neuropathic
             diterpenoid alkaloid,attenuates chronic neuropathic pain
                                                                 pain[J]. Neural Plast,2018. DOI:10.1155/2018/9347696.
             through stimulating ERK/CREB signaling pathway-medi-
                                                                         (收稿日期:2020-03-27  修回日期:2020-04-16)
             ated microglial dynorphin a expression[J]. J Neuroinflam-
                                                                                                 (编辑:唐晓莲)
             mation,2020. DOI:10.1186/s12974-019-1696-9.
        [ 9 ]  WANG A,TIE M,GUO D,et al. A novel mechanism of





        ·1588  ·  China Pharmacy 2020 Vol. 31 No. 13                                中国药房    2020年第31卷第13期
   53   54   55   56   57   58   59   60   61   62   63