Page 58 - 202013
P. 58
著 降 低 脊 髓 背 角 内 Iba-1、p-p38MAPK、IL-6、IL-1 β 、 BAM8-22 inhibiting microglia activation: represses
TNF-α蛋白的表达水平。 CX3CR1 expression via upregulating miR-184[J]. J Mol
综上所述,鞘内给予 8-OaS 可有效缓解大鼠慢性炎 Neurosci,2019. DOI:10.1007/s12031-019-01455-0.
性痛,其机制可能与抑制 p38 MAPK 磷酸化和 IL-6、IL- [10] YAZDZNI J,KHIAVI RK,GHAVIMI MA,et al. Calcito-
1β、TNF-α的表达有关。 nin as an analgesic agent:review of mechanisms of action
and clinical applications[J]. Rev Bras Anestesiol,2019.
参考文献
DOI:10.1016/j.bjan.2019.08.004.
[ 1 ] TURUNEN A,KUULIALA A,PENTTILA A,et al. Time
[11] HE JH,YU L,WANG ZY,et al. Inhibition of monocar-
course of signaling profiles of blood leukocytes in acute
boxylate transporter 1 in spinal cord horn significantly re-
pancreatitis and sepsis[J]. Scand J Clin Lab Invest,2020,
verses chronic inflammatory pain[J]. J Pain Res,2019,12
80(2):114-123.
(5):2981-2990.
[ 2 ] MCWILLIAMS DF,RAHMAN S,JAMES RJE,et al.
[12] SHINODA M,KUBO A,HAYASHI Y,et al. Peripheral
Disease activity flares and pain flares in an early rheuma-
and central mechanisms of persistent orofacial pain [J].
toid arthritis inception cohort;characteristics,antecedents
Front Neurosci,2019. DOI:10.3389/fnins.2019.01227.
and sequelae[J]. BMC Rheumatol,2019. DOI:10.1186/
[13] DU HX,CHEN XG,ZHANG L,et al. Microglial activa-
s41927-019-0100-9.
tion and neurobiological alterations in experimental auto-
[ 3 ] BARROS LL,FARIAS AQ,REZAIE A. Gastrointestinal
immune prostatitis-induced depressive-like behavior in
motility and absorptive disorders in patients with inflam-
mice[J]. Neuropsychiatr Dis Treat,2019,15(6):2231-
matory bowel diseases:prevalence,diagnosis and treat-
2245.
ment[J]. World J Gastroenterol,2019,25(31):4414-
[14] QIN B,LI Y,LIU X,et al. Notch activation enhances mi-
4426.
croglial CX3CR1/P38 MAPK pathway in rats model of
[ 4 ] EIDSON LN,MURPHY AZ. Inflammatory mediators of
vincristine-induced peripheral neuropathy[J]. Neurosci
opioid tolerance:implications for dependency and addic-
Lett,2019. DOI:10.1016/j.neulet.2019.134624.
tion[J]. Peptides,2019. DOI:10.1016/j.peptides.2019.01.
[15] PAIGE C,MARUTHY GB,MEJIA G,et al. Spinal inhibi-
003.
tion of P2XR or p38 signaling disrupts hyperalgesic prim-
[ 5 ] WANG J,QIAO Y,YANG RS,et al. The synergistic ef-
ing in male,but not female,mice[J]. Neuroscience,2018,
fect of treatment with triptolide and MK-801 in the rat
385(10):133-142.
neuropathic pain model[J]. Mol Pain,2017. DOI:10.1177/
[16] FUJITA M,TAMANO R,YONEDA S,et al. Ibudilast pro-
1744806917746564.
duces anti-allodynic effects at the persistent phase of pe-
[ 6 ] 王健,肖小莉,崔佳,等. 8-O-乙酰山栀子苷甲酸对慢性
ripheral or central neuropathic pain in rats:different inhibi-
炎性痛模型大鼠脊髓背角内 HDAC1~5 表达的影响及
tory mechanism on spinal microglia from minocycline
与 JAK2-STAT3 信号通路的关系研究[J].中国药房,
and propentofylline[J]. Eur J Pharmacol,2018,833(15):
2019,30(5):38-43.
263-274.
[ 7 ] ZHANG W,BAI Y,QIAO Y,et al. 8-O-acetyl shanzhi-
[17] CHENG H,ZHANG Y,LU W,et al. Caffeic acid pheneth-
side methylester from lamiophlomis rotata reduces neuro-
yl ester attenuates neuropathic pain by suppressing the
pathic pain by inhibiting the ERK/TNF-α pathway in spi-
p38/NF-κ B signal pathway in microglia[J]. J Pain Res,
nal astrocytes[J]. Front Cell Neurosci,2018. DOI:10.
2018,11(1):2709-2719.
3389/fncel.2018.00054.
[18] JIN GL,HE SD,LIN SM,et al. Koumine attenuates neuro-
[ 8 ] SHUAI S,HUAN X,MIN H,et al. Isotalatizidine,a C19-
glia activation and inflammatory response to neuropathic
diterpenoid alkaloid,attenuates chronic neuropathic pain
pain[J]. Neural Plast,2018. DOI:10.1155/2018/9347696.
through stimulating ERK/CREB signaling pathway-medi-
(收稿日期:2020-03-27 修回日期:2020-04-16)
ated microglial dynorphin a expression[J]. J Neuroinflam-
(编辑:唐晓莲)
mation,2020. DOI:10.1186/s12974-019-1696-9.
[ 9 ] WANG A,TIE M,GUO D,et al. A novel mechanism of
·1588 · China Pharmacy 2020 Vol. 31 No. 13 中国药房 2020年第31卷第13期