Page 133 - 《中国药房》2026年5期
P. 133
[13] LAMIA K A,SACHDEVA U M,DITACCHIO L,et al. 机制的研究进展[J]. 中草药,2023,54(14):4722-4731.
AMPK regulates the circadian clock by cryptochrome [27] LI J,WEI L P,ZHAO C C,et al. Resveratrol maintains
phosphorylation and degradation[J]. Science,2009,326 lipid metabolism homeostasis via one of the mechanisms
(5951):437-440. associated with the key circadian regulator BMAL1[J].
[14] BROWN D A,PERRY J B,ALLEN M E,et al. Expert Molecules,2019,24(16):2916.
consensus document:mitochondrial function as a thera‐ [28] 吕芳,苏幼红,张富春,等. 植物活性成分对表观遗传调
peutic target in heart failure[J]. Nat Rev Cardiol,2017,14 节的研究概况[J]. 中草药,2008,39(10):1580-1583.
(4):238-250. [29] 王玉真,高爽,李凌军,等. 菊苣酸生物活性及其药理作
[15] THAI P N,DAUGHERTY D J,FREDERICH B J,et al. 用研究进展[J]. 中国新药杂志,2020,29(15):1729-1733.
Cardiac-specific conditional knockout of the 18-kDa mito‐ [30] GUO R,ZHAO B T,WANG Y J,et al. Cichoric acid pre‐
chondrial translocator protein protects from pressure over‐ vents free-fatty-acid-induced lipid metabolism disorders
load induced heart failure[J]. Sci Rep,2018,8(1):16213. via regulating BMAL1 in HepG2 cells[J]. J Agric Food
[16] WANG P W,YU B H,LIU L J,et al. Role of circadian Chem,2018,66(37):9667-9678.
rhythms in heart failure:insights from myocardial energy [31] 程会军 . EGCG 通过生物钟基因 BMAL1 减轻高脂诱导
metabolism[J]. J Transl Med,2025,23(1):770. 小鼠代谢紊乱的效应和机制[D]. 合肥:安徽农业大学,
[17] XIN M L,BI F J,WANG C,et al. The circadian rhythm:a 2022.
new target of natural products that can protect against dis‐ [32] MI Y S,QI G Y,FAN R,et al. EGCG ameliorates diet-
eases of the metabolic system,cardiovascular system,and induced metabolic syndrome associating with the circa‐
nervous system[J]. J Adv Res,2025,69:495-514. dian clock[J]. Biochim Biophys Acta BBA Mol Basis Dis,
[18] LI X D,ZHUANG R X,LU Z T,et al. Nobiletin promotes 2017,1863(6):1575-1589.
lipolysis of white adipose tissue in a circadian clock- [33] 王丹妮,郭晋良,仝立国,等 . 蛇床子催眠活性组分对
dependent manner[J]. J Nutr Biochem,2024,132:109696. PCPA损伤大鼠松果体细胞的保护作用及钟基因表达调
[19] NEBA AMBE G N N,BREDA C,BHAMBRA A S,et al. 控机制[J]. 中药材,2021,44(1):182-185.
Effect of the Citrus Flavone nobiletin on circadian [34] 王小燕. 小鼠高脂晚餐对肝脏生物钟和脂质生成基因表
rhythms and metabolic syndrome[J]. Molecules,2022,27 达影响以及蛇床子素干预作用研究[D]. 苏州:苏州大
(22):7727. 学,2013.
[20] MILEYKOVSKAYA E,YOO S H,DOWHAN W,et al. [35] 罗乐,黄仕芳,李玉婷. 熊果酸对脂多糖诱导小鼠急性肺
Nobiletin:targeting the circadian network to promote bio‐ 损伤的保护作用及机制[J]. 中南农业科技,2025,46(6):
energetics and healthy aging[J]. Biochemistry,2020,85 79-81,106.
(12):1554-1559. [36] KWON E Y,SHIN S K,CHOI M S. Ursolic acid attenu‐
[21] HE B K,NOHARA K,PARK N,et al. The small mol‐ ates hepatic steatosis,fibrosis,and insulin resistance by
ecule nobiletin targets the molecular oscillator to enhance modulating the circadian rhythm pathway in diet-induced
circadian rhythms and protect against metabolic syndrome obese mice[J]. Nutrients,2018,10(11):1719.
[J]. Cell Metab,2016,23(4):610-621. [37] LI Q Y,ZHANG S Z,LI Y Y,et al. Astragaloside Ⅳ alle‐
[22] OKADA Y,OKADA M. Quercetin,caffeic acid and resvera- viates radiation-induced heart disease by regulating en‐
trol regulate circadian clock genes and aging-related genes ergy metabolism[J]. Phytomedicine,2025,146:157135.
in young and old human lung fibroblast cells[J]. Mol Biol [38] LIU J,GAO D X,DAN J H,et al. The protective effect of
Rep,2020,47(2):1021-1032. cycloastragenol on aging mouse circadian rhythmic disor‐
[23] XU L Y,ZHAO W J,WANG D M,et al. Chinese medi‐ der induced by D-galactose[J]. J Cell Biochem,2019,120
cine in the battle against obesity and metabolic diseases (10):16408-16415.
[J]. Front Physiol,2018,9:850. [39] HA H,SHIN H,MIN S,et al. Therapeutic potential of gin‐
[24] 努尔比耶·努尔艾合麦提,地力乎马·地力木拉提,阿乐 senosides in circadian rhythm-based skin disorders[J]. J
哈尔·拜山,等 . 基于 PI3K/Akt 信号通路探讨氧化小檗 Ginseng Res,2025,49(4):366-375.
碱和小檗胺对心肌细胞的保护作用[J]. 中南药学,2025, [40] 刘燃,林志,杨帆,等. 人参皂苷Rg1通过Sestrin2保护心
23(8):2290-2297. 肌细胞的作用[J]. 昆明医科大学学报,2023,44(6):
[25] 张玮芸,HO C T,吕慕雯 . 基于脂质组学研究胡椒碱对 19-25.
肥胖大鼠脂代谢基因昼夜节律的影响[J]. 食品科学, (收稿日期:2025-09-02 修回日期:2026-01-04)
2024,45(9):124-134. (编辑:邹丽娟)
[26] 王琴,杨斌,顾健,等. 中药多酚类成分抗肿瘤表观遗传
中国药房 2026年第37卷第5期 China Pharmacy 2026 Vol. 37 No. 5 · 675 ·

