Page 31 - 《中国药房》2025年12期

[ 5 ] GARCÍA-CERRO S，GÓMEZ-GARRIDO A，GARCIA metabolism pathway of peripheral T lymphocytes and
G，et al. Exploratory analysis of microRNA alterations in ketamine-induced schizophrenia-like phenotype[J]. J Psy‐
a neurodevelopmental mouse model for autism spectrum chiatry Neurosci，2024，49（6）：E413-E426.
disorder and schizophrenia[J]. Int J Mol Sci，2024，25（5）： [15] ZHANG X T，ZHAO J H，CHANG T，et al. Ketamine
2786. exerts neurotoxic effects on the offspring of pregnant rats
[ 6 ] WAN J，MA L H，JIAO X H，et al. Impaired synaptic plas‐ via the Wnt/β-catenin pathway[J]. Environ Sci Pollut Res
ticity and decreased excitability of hippocampal glutama‐ Int，2020，27（1）：305-314.
tergic neurons mediated by BDNF downregulation con‐ [16] MENZIKOV S A，MOROZOV S G，KUBATIEV A A. In‐
tribute to cognitive dysfunction in mice induced by re‐ tricacies of GABAA receptor function：the critical role of
peated neonatal exposure to ketamine[J]. CNS Neurosci the β3 subunit in norm and pathology[J]. Int J Mol Sci，
Ther，2024，30（2）：e14604. 2021，22（3）：1457.
[ 7 ] LUO Y Y，YU Y，ZHANG M L，et al. Chronic administra‐ [17] LING Z N，JIANG Y F，RU J N，et al. Amino acid metabo‐
tion of ketamine induces cognitive deterioration by re- lism in health and disease[J]. Signal Transduct Target
straining synaptic signaling[J]. Mol Psychiatry，2021，26 Ther，2023，8（1）：345.
（9）：4702-4718. [18] ALBRECHT J， SIDORYK-WEGRZYNOWICZ M，
[ 8 ] RUPERT D D，SHEA S D. Parvalbumin-positive interneu‐ ZIELINSKA M，et al. Roles of glutamine in neurotrans‐
rons regulate cortical sensory plasticity in adulthood and mission [J]. Neuron Glia Biol，2010，6（4）：263-276.
development through shared mechanisms[J]. Front Neural [19] KANSAKAR U，TRIMARCO V，MONE P，et al. Choline
Circuits，2022，16：886629. supplements：an update[J]. Front Endocrinol（Lausanne），
[ 9 ] HISER J，KOENIGS M. The multifaceted role of the ven‐ 2023，14：1148166.
tromedial prefrontal cortex in emotion，decision making， [20] MCGOWAN J C，HILL C，MASTRODONATO A，et al.
social cognition，and psychopathology[J]. Biol Psychiatry， Prophylactic ketamine alters nucleotide and neurotransmit‐
2018，83（8）：638-647. ter metabolism in brain and plasma following stress[J].
[10] 严秀莺，向平，于治国，等. 代谢组学在滥用物质毒理学 Neuropsychopharmacology，2018，43（9）：1813-1821.
研究中的应用[J]. 法医学杂志，2022，38（3）：400-407. [21] CHATTERJEE M，VERMA R，GANGULY S，et al. Neu‐
[11] WEI Y，XIAO L，FAN W H，et al. Astrocyte activation， rochemical and molecular characterization of ketamine-
but not microglia，is associated with the experimental induced experimental psychosis model in mice[J]. Neuro‐
mouse model of schizophrenia induced by chronic ke- pharmacology，2012，63（6）：1161-1171.
tamine[J]. J Mol Neurosci，2022，72（9）：1902-1915. [22] BEN-AZU B，OMOGBIYA I A，ADERIBIGBE A O，et al.
[12] 李新存，彭东辉，王永福，等. 基于代谢组学研究柴胡皂 Doxycycline prevents and reverses schizophrenic-like
苷C对急性肝损伤小鼠的保护作用[J].中国药房，2025， behaviors induced by ketamine in mice via modulation of
36（5）：552-557. oxidative，nitrergic and cholinergic pathways[J]. Brain
[13] BOULESTEIX A L，STRIMMER K. Partial least squares： Res Bull，2018，139：114-124.
a versatile tool for the analysis of high-dimensional genomic （收稿日期：2025-01-22 修回日期：2025-05-15）
data[J]. Brief Bioinform，2007，8（1）：32-44. （编辑：邹丽娟）
[14] WANG P P，JIANG L Z，HU J M，et al. The amino acid

中国药房 2025年第36卷第12期 China Pharmacy 2025 Vol. 36 No. 12 · 1441 ·