Page 50 - 《中国药房》2025年10期

结果显示，DMOG 可显著逆转安石榴苷的镇痛作用，提 2022，76（1）：314-320.
示安石榴苷可能通过下调HIF-1α/NLRP3信号通路来缓 [11] JAIN V，PAREEK A，BHARDWAJ Y R，et al. Punicala‐
解大鼠的NP。 gin and ellagic acid containing Punica granatum L. fruit
综上所述，安石榴苷可缓解NP大鼠的疼痛，其镇痛 rind extract prevents vincristine-induced neuropathic pain
in rats：an in silico and in vivo evidence of GABAergic ac‐
作用可能是通过抑制 HIF-1α/NLRP3 信号通路，阻碍脊
tion and cytokine inhibition[J]. Nutr Neurosci，2022，25
髓背角小胶质细胞中 NLRP3 炎症小体的活化来实现
（10）：2149-2166.
的。未来本课题组将探讨安石榴苷发挥镇痛作用的其
[12] PENG J F，ZHAO X N，ZHANG M，et al. Punicalagin at‐
他靶点，同时采用其他 NP 模型对其镇痛作用及机制进 tenuates ventricular remodeling after acute myocardial in‐
行深入分析，并在此基础上分析安石榴苷的药动学和体 farction via regulating the NLRP3/caspase-1 pathway[J].
内代谢过程，探讨其实际应用的可行性。 Pharm Biol，2023，61（1）：963-972.
参考文献 [13] 姜政男，张溢珈，刘臻，等. 大鼠神经病理性疼痛模型的
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