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高剂量布美他尼处理的 COPD 大鼠给予 PY-60 处理,发                          burden of chronic obstructive pulmonary disease(COPD):
          现PY-60可显著逆转布美他尼对COPD大鼠肺损伤的改                              a systematic literature review[J]. Int J Chron Obstruct Pul‐
          善作用,进一步证明了布美他尼可通过抑制YAP/TAZ信                              mon Dis,2020,15:439-460.
          号通路来减轻COPD大鼠肺损伤。                                    [13]  ZUO S K,WANG B,LIU J,et al. ER-anchored CRTH2
              综上所述,布美他尼可减轻 COPD 大鼠肺损伤,改                            antagonizes  collagen  biosynthesis  and  organ  fibrosis  via
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          善炎症反应及肺纤维化,其作用机制与抑制YAP/TAZ信
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          号通路相关。
                                                                   glycyrrhizinate  inhibits  airway  inflammation  in  rats  with
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          · 944 ·    China Pharmacy  2025 Vol. 36  No. 8                               中国药房  2025年第36卷第8期
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