Page 131 - 《中国药房》2025年4期
P. 131
需要说明的是,尽管最新的 SS 相关专家共识明确 and tall stature:a new paradigm emerges[J]. Nat Rev
[38]
指出了AIs用于治疗SS的有效性及使用剂量推荐 ,但 Endocrinol,2015,11(12):735-746.
AIs 用于 SS 在我国仍属于超说明书用药,临床使用 AIs [12] SHU W,NIU W Q,ZHANG Y Q,et al. Association
时仍需谨慎。使用 AIs 前,医生需要向患儿家长明确说 between sex hormones and bone age in boys aged 9-18
明药物的不良反应、获益及风险,获得充分的知情同意, years from China[J]. J Cell Mol Med,2024,28(7):
e18181.
尊重患儿家庭的选择,确保在使用 AIs 后能进行长期的
[13] HERO M. Aromatase inhibitors in the treatment of short
随访观察,以保障患儿用药的安全性和治疗效果的最
stature[J]. Endocr Dev,2016,30:130-140.
优化。
[14] SHOUNG N,HO K K Y. Managing estrogen therapy in
参考文献
the pituitary patient[J]. J Endocr Soc,2023,7(5):
[ 1 ] 陈伟伟,刘焕欣,刘晶,等. 儿童身材矮小的病因分析及
bvad051.
遗 传 学 诊 断 [J]. 中 国 当 代 儿 科 杂 志 ,2019,21(4):
[15] BARROS-OLIVEIRA M D C,COSTA-SILVA D R,
381-386.
ANDRADE D B,et al. Use of anastrozole in the chemo‐
CHEN W W,LIU H X,LIU J,et al. Etiology and genetic
prevention and treatment of breast cancer:a literature
diagnosis of short stature in children[J]. Chin J Contemp
review[J]. Rev Assoc Med Bras(1992),2017,63(4):
Pediatr,2019,21(4):381-386.
371-378.
[ 2 ] MA J,PEI T,DONG F,et al. Spatial and demographic dis‐
[16] CAIRNS J,KALARI K R,INGLE J N,et al. Interaction
parities in short stature among school children aged 7-18
between SNP genotype and efficacy of anastrozole and
years:a nation-wide survey in China,2014[J]. BMJ Open,
exemestane in early-stage breast cancer[J]. Clin Pharmacol
2019,9(7):e026634.
Ther,2021,110(4):1038-1049.
[ 3 ] COLLETT-SOLBERG P F,JORGE A A L,BOGUSZEWSKI
[17] 孔元梅,陈虹,梁黎,等. 芳香化酶抑制剂联合生长激素
M C S,et al. Growth hormone therapy in children: research
治疗青春期身材矮小症男性患儿的临床研究[J]. 浙江大
and practice: a review[J]. Growth Horm IGF Res,2019,
学学报(医学版),2020,49(3):283-290.
44:20-32.
KONG Y M,CHEN H,LIANG L,et al. Aromatase inhibi‐
[ 4 ] POLIDORI N,CASTORANI V,MOHN A,et al. Deci‐
tors combined with growth hormone in treatment of ado‐
phering short stature in children[J]. Ann Pediatr Endocri‐
lescent boys with short stature[J]. J Zhejiang Univ Med
nol Metab,2020,25(2):69-79.
[ 5 ] MCGRATH N,O’GRADY M J. Aromatase inhibitors for Sci,2020,49(3):283-290.
[18] BERTELSEN B E,VISTE K,HELLAND T,et al. Simul‐
short stature in male children and adolescents[J]. Co‐
chrane Database Syst Rev,2015,2015(10):CD010888. taneous quantification of aromatase inhibitors and estro‐
[ 6 ] SAROUFIM R,EUGSTER E A. Non-GH agents and gens in postmenopausal breast cancer patients[J]. J Clin
novel therapeutics in the management of short stature[J]. Endocrinol Metab,2022,107(5):1368-1374.
Indian J Pediatr,2021,88(12):1209-1213. [19] GHOSH D,LO J,EGBUTA C. Recent progress in the dis‐
[ 7 ] HERO M,TOIVIAINEN-SALO S,WICKMAN S,et al. covery of next generation inhibitors of aromatase from the
Vertebral morphology in aromatase inhibitor-treated males structure-function perspective[J]. J Med Chem,2016,59
with idiopathic short stature or constitutional delay of (11):5131-5148.
puberty[J]. J Bone Miner Res,2010,25(7):1536-1543. [20] 王敏,李敏,刘悦笙,等 . LHCGR 基因突变(Asp578His)
[ 8 ] MASTROMAURO C,GIANNINI C,CHIARELLI F. 致家族性男性性早熟1例临床特点及基因分析[J]. 中国
Short stature related to growth hormone insensitivity 当代儿科杂志,2017,19(11):1159-1164.
(GHI)in childhood[J]. Front Endocrinol(Lausanne), WANG M,LI M,LIU Y S,et al. Familial male-limited
2023,14:1141039. precocious puberty due to Asp578His mutations in the
[ 9 ] SARVER D C,GARCIA-DIAZ J,SAQIB M,et al. LHCGR gene:clinical characteristics and gene analysis in
Tmem263 deletion disrupts the GH/IGF-1 axis and causes an infant[J]. Chin J Contemp Pediatr,2017,19(11):1159-
dwarfism and impairs skeletal acquisition[J]. eLife,2024, 1164.
12:RP90949. [21] AUGUSTO T V,CORREIA-DA-SILVA G,RODRIGUES
[10] ALLEN D B,MERCHANT N,MILLER B S,et al. Evolu‐ C M P,et al. Acquired resistance to aromatase inhibitors:
tion and future of growth plate therapeutics[J]. Horm Res where we stand![J]. Endocr Relat Cancer,2018,25(5):
Paediatr,2021,94(9/10):319-332. R283-R301.
[11] BARON J,SÄVENDAHL L,DE LUCA F,et al. Short [22] SADASIVAM K,MANOHARAN J P,PALANISAMY
中国药房 2025年第36卷第4期 China Pharmacy 2025 Vol. 36 No. 4 · 505 ·