Page 130 - 《中国药房》2024年17期
P. 130
[15] AZZAM A A H,LAMBERT D G. Preclinical discovery sics[J]. Drugs,2023,83(9):771-793.
and development of oliceridine (Olinvyk ) for the treat‐ [27] DING H P,TRAPELLA C,KIGUCHI N,et al. Functional
®
ment of post-operative pain[J]. Expert Opin Drug Discov, profile of systemic and intrathecal cebranopadol in nonhu‐
2022,17(3):215-223. man Primates[J]. Anesthesiology,2021,135(3):482-493.
[16] DAKSLA N,WANG A,JIN Z S,et al. Oliceridine for the [28] HE C B,WANG X L,ZHANG J,et al. MCRT,a multi‐
management of moderate to severe acute postoperative functional ligand of opioid and neuropeptide FF receptors,
pain:a narrative review[J]. Drug Des Devel Ther,2023, attenuates neuropathic pain in spared nerve injury model
17:875-886. [J]. Basic Clin Pharmacol Toxicol,2021,128(6):731-740.
[17] MANGLIK A,LIN H,ARYAL D K,et al. Structure-based [29] ZHANG M N,XU B,LI N,et al. Development of multi‐
discovery of opioid analgesics with reduced side effects functional and orally active cyclic peptide agonists of
[J]. Nature,2016,537(7619):185-190. opioid/neuropeptide FF receptors that produce potent,
[18] DING H P,KIGUCHI N,PERREY D A,et al. Antinoci‐ long-lasting,and peripherally restricted antinociception
ceptive,reinforcing,and pruritic effects of the G-protein with diminished side effects[J]. J Med Chem,2021,64
signalling-biased mu opioid receptor agonist PZM21 in (18):13394-13409.
non-human primates[J]. Br J Anaesth,2020,125(4): [30] XU B,ZHANG M N,SHI X R,et al. The multifunctional
596-604. peptide DN-9 produced peripherally acting antinocicep‐
[19] MA M J,LI X,TONG K,et al. Discovery of biased tion in inflammatory and neuropathic pain via μ- and κ-
mu-opioid receptor agonists for the treatment of pain[J]. opioid receptors[J]. Br J Pharmacol,2020,177(1):
ChemMedChem,2020,15(1):155-161. 93-109.
[20] ZHUANG Y W,WANG Y,HE B Q,et al. Molecular reco- [31] WANG Y H,CHAI J R,XU X J,et al. Pharmacological
gnition of morphine and fentanyl by the human μ-opioid characterization of dezocine,a potent analgesic acting as a
receptor[J]. Cell,2022,185(23):4361-4375.e19. κ partial agonist and μ partial agonist[J]. Sci Rep,2018,8
[21] DHILLON S. Tegileridine:first approval[J]. Drugs,2024, (1):14087.
84(6):717-720. [32] SETH R,KUPPALLI S S,NADAV D,et al. Recent ad‐
[22] KABIR A,MUTH A. Polypharmacology:the science of vances in peripheral opioid receptor therapeutics[J]. Curr
multi-targeting molecules[J]. Pharmacol Res,2022,176: Pain Headache Rep,2021,25(7):46.
106055. [33] JIMÉNEZ-VARGAS N N,YU Y,JENSEN D D,et al.
[23] SMITH M T,KONG D H,KUO A,et al. Multitargeted Agonist that activates the µ-opioid receptor in acidified
opioid ligand discovery as a strategy to retain analgesia microenvironments inhibits colitis pain without side ef‐
and reduce opioid-related adverse effects[J]. J Med Chem, fects[J]. Gut,2022,71(4):695-704.
2023,66(6):3746-3784. [34] DEGRO C E,JIMÉNEZ-VARGAS N N,TSANG Q,et al.
[24] 陈泽权,肖国伟,敖健,等. 阿片受体激动-拮抗剂的镇痛 Evolving acidic microenvironments during colitis provide
作用及不良反应研究进展[J]. 中国药房,2023,34(18): selective analgesic targets for a pH-sensitive opioid[J].
2299-2304. Pain,2023,164(11):2501-2515.
CHEN Z Q,XIAO G W,AO J,et al. Research progress [35] FENG J,LEPETRE-MOUELHI S,GAUTIER A,et al. A
on analgesic effect and adverse drug reactions of opioid re‐ new painkiller nanomedicine to bypass the blood-brain
ceptor agonist-antagonists[J]. China Pharm,2023,34 barrier and the use of morphine[J]. Sci Adv,2019,5(2):
(18):2299-2304. eaau5148.
[25] MADA S,GERAK L R,SOYER A,et al. Behavioral ef‐ [36] LEBON B,ZEPPETELLA G,HIGGINSON I J. Effective‐
fects of benzylideneoxymorphone (BOM),a low efficacy ness of topical administration of opioids in palliative care:
µ opioid receptor agonist and a δ opioid receptor antago‐ a systematic review[J]. J Pain Symptom Manage,2009,37
nist[J]. Psychopharmacology,2020,237(12):3591-3602. (5):913-917.
[26] DING H P,KIGUCHI N,DOBBINS M,et al. Nociceptin (收稿日期:2023-12-29 修回日期:2024-08-14)
receptor-related agonists as safe and non-addictive analge‐ (编辑:胡晓霖)
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