Page 58 - 《中国药房》2024年10期
P. 58
优于同质量浓度 Cur 对照品溶液,提示该胶束的药效作 ration of liver protecting solid beverage[D]. Guangzhou:
用时间更长。 South China University of Technology,2021.
综上所述,本研究所制 Cur/mPEG-PBLA 胶束不仅 [10] DENG Y Q,JIN Y,HE C Y,et al. Preparation and
可有效提高 Cur 的溶解性和 pH 稳定性、热稳定性,还能 characterization of intestine PepT1-targeted calcium
carbonate nanoparticles[J]. J Chin Pharm Sci,2018,27
延缓其释放速度;同时,Cur/mPEG-PBLA胶束具有一定
(6):397-407.
的体外抗ALD活性,且随着干预时间的延长,其活性强
[11] 邓薇,张洪,高洁芳,等. 大蒜素聚合物胶束的制备及质
于Cur对照品溶液。
量评价[J]. 中国药师,2019,22(4):759-763.
参考文献 DENG W,ZHANG H,GAO J F,et al. Preparation and
[ 1 ] 潘家姝,喻晓,邢练军. 中医药治疗酒精性肝病的相关研 quality evaluation of diallyl trisulfide polymeric micelles
究进展[J]. 中西医结合肝病杂志,2022,32(10):957-960. [J]. China Pharm,2019,22(4):759-763.
PAN J S,YU X,XING L J. Research progress on treat‐ [12] ZUCKERMAN J E,DAVIS M E. Clinical experiences
ment of alcoholic liver disease with traditional Chinese with systemically administered siRNA-based therapeutics
medicine[J]. Chin J Integr Tradit West Med Liver Dis, in cancer[J]. Nat Rev Drug Discov,2015,14(12):843-856.
2022,32(10):957-960. [13] YALLAPU M M,NAGESH P K,JAGGI M,et al. Thera‐
[ 2 ] SHAFIEE M,MOHAMADZADE E,SHAHIDSALES S, peutic applications of curcumin nanoformulations[J].
et al. Current status and perspectives regarding the thera‐ AAPS J,2015,17(6):1341-1356.
peutic potential of targeting EGFR pathway by curcumin [14] 陈永超,蒲晓辉,宗兰兰,等. 两亲性嵌段共聚物聚乙二
in lung cancer[J]. Curr Pharm Des,2017,23(13):2002- 醇-聚天冬氨酸苄酯的合成与表征[J]. 河南大学学报(自
2008. 然科学版),2015,45(4):410-416.
[ 3 ] TIAN C H,ASGHAR S,WU Y F,et al. Improving intestinal CHEN Y C,PU X H,ZONG L L,et al. Synthesis and
absorption and oral bioavailability of curcumin via tau- characterization of amphiphilic block copolymer of poly
rocholic acid-modified nanostructured lipid carriers[J]. Int (ethylene glycol)-poly(β-benzyl-L-aspartic)[J]. J Henan
J Nanomedicine,2017,12:7897-7911. Univ Nat Sci,2015,45(4):410-416.
[ 4 ] WANG Y L,JU B,ZHANG Y Z,et al. Protective effect of [15] ZONG L L,WANG Y L,SONG S Y,et al. Formulation
curcumin against oxidative stress-induced injury in rats and evaluation on synergetic anti-hepatoma effect of a
with Parkinson’s disease through the Wnt/β-catenin chemically stable and release-controlled nanoself-assembly
signaling pathway[J]. Cell Physiol Biochem,2017,43(6): with natural monomers[J]. Int J Nanomedicine,2023,18:
2226-2241. 3407-3428.
[ 5 ] SOHILAIT M R,PRANOWO H D,HARYADI W. [16] ZONG L L,WANG H Y,HOU X Q,et al. A novel GSH-
Molecular docking analysis of curcumin analogues with triggered polymeric nanomicelles for reversing MDR and
COX-2[J]. Bioinformation,2017,13(11):356-359. enhancing antitumor efficiency of hydroxycamptothecin
[ 6 ] CHU J Y,YAN R,WANG S,et al. Sinapic acid reduces [J]. Int J Pharm,2021,600:120528.
oxidative stress and pyroptosis via inhibition of BRD4 in [17] LI G L,YE Y,KANG J J,et al. L-theanine prevents alco‐
alcoholic liver disease[J]. Front Pharmacol,2021,12: holic liver injury through enhancing the antioxidant capa‐
668708. bility of hepatocytes[J]. Food Chem Toxicol,2012,50(2):
[ 7 ] SAADATI S,SADEGHI A,MANSOUR A,et al. Curcumin 363-372.
and inflammation in non-alcoholic fatty liver disease:a [18] TAPAL A,TIKU P K. Complexation of curcumin with soy
protein isolate and its implications on solubility and stabi-
randomized,placebo controlled clinical trial[J]. BMC
Gastroenterol,2019,19(1):133. lity of curcumin[J]. Food Chem,2012,130(4):960-965.
[19] YANG Q L,XU W W,CHENG M,et al. Controlled
[ 8 ] KIM S G,SUH H J,HAN S H,et al. Encapsulated
release of drug molecules by pillararene-modified nanosys‐
curcumin enhances intestinal absorption and improves
tems[J]. Chem Commun,2022,58(20):3255-3269.
hepatic damage in alcoholic liver disease-induced rats[J].
[20] WEST K H J,GAHAN C G,KIERSKI P R,et al. Sus‐
Prev Nutr Food Sci,2019,24(4):410-417.
[ 9 ] 戴伊繁. 河蚬多肽与姜黄素对酒精性肝损伤保护作用的 tained release of a synthetic autoinducing peptide mimetic
blocks bacterial communication and virulence in vivo[J].
研究及其护肝固体饮料的研制[D]. 广州:华南理工大
Angew Chem Int Ed Engl,2022,61(24):e202201798.
学,2021.
(收稿日期:2023-10-12 修回日期:2024-03-28)
DAI Y F. Protective effects of Corbicula fluminea poly‐
(编辑:张元媛)
peptide and curcumin on alcoholic liver injury and prepa‐
· 1208 · China Pharmacy 2024 Vol. 35 No. 10 中国药房 2024年第35卷第10期