Page 121 - 《中国药房》2023年21期

基于“厚肠”理论的中医药调控黏液屏障干预溃疡性结肠炎的机

制研究进展
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王金鑫 ，黎丽群 ，黄晓燕 ，黄茂光 ，罗 峰 ，陈月莹 ，李玉玲 ，谢 胜 ，刘园园 （1.广西中医药大学研究生
学院，南宁 530001；2.广西中医药大学第一附属医院脾胃病科二区，南宁 530023；3.广西中医药大学第一附
属医院中医治未病中心，南宁 530023）
中图分类号 R285；R965 文献标志码 A 文章编号 1001-0408（2023）21-2671-07
DOI 10.6039/j.issn.1001-0408.2023.21.18
摘 要 溃疡性结肠炎（UC）是临床慢性肠道病变，肠上皮黏液屏障受损是该病的重要病理机制。黏蛋白2（MUC2）是肠道黏液
屏障的主要组成部分，而杯状细胞是分泌MUC2的“主力军”，可维持和更新肠黏液层，保证其完整性。因此，通过促进杯状细胞合
成MUC2从而修复肠道黏液屏障，是治疗UC的重要策略。中医学者认为肠道中存在一层固有的“脂膜”或“脂膏”，湿热等病理因
素导致该结构变薄，是“腹泻”“肠澼”发生的根本病机，这与现代医学中肠道黏液屏障受损导致UC不谋而合。本文通过总结中药
复方或中药活性成分调控肠道黏液屏障干预UC的作用机制发现，黄连解毒汤、芍药汤、复方苦参汤等中药复方以及苍术挥发油、
芍药苷、木瓜三萜等中药活性成分可通过促进杯状细胞合成分泌功能，达到“厚肠”的目的，进而改善UC症状。
关键词 中医药；溃疡性结肠炎；黏蛋白2；杯状细胞；肠道黏液屏障

Research advance in the mechanism exploration of traditional Chinese medicine regulating mucus barrier
and interfering with ulcerative colitis based on the “thickening intestine” theory
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WANG Jinxin ，LI Liqun ，HUANG Xiaoyan ，HUANG Maoguang ，LUO Feng ，CHEN Yueying ，LI Yuling ，XIE
Sheng ，LIU Yuanyuan（1. School of Graduate， Guangxi University of Traditional Chinese Medicine，Nanning
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530001，China；2. Second Area of Department of Spleen and Stomach Diseases， the First Affiliated Hospital of
Guangxi University of Traditional Chinese Medicine，Nanning 530023，China；3. Center for Chinese Medicine
Disease Prevention， the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine，
Nanning 530023， China）
ABSTRACT Ulcerative colitis （UC） is a clinical chronic intestinal disease， and the damage of the intestinal epithelial mucus
barrier is an important pathological mechanism of UC. Mucin 2 （MUC2） is a major component of the intestinal mucus barrier， and
goblet cells are the “main force” of MUC2 secretion， maintaining and renewing the intestinal mucus layer to ensure its integrity.
Therefore， repairing the intestinal mucus barrier by promoting the synthesis of MUC2 by goblet cells is an important strategy for
the treatment of UC. Traditional Chinese medicine scholars believe that there is an inherent layer of “lipid membrane” or “fat paste”
in the intestine， and pathological factors such as moisture and heat lead to the thinning of this structure， which is the fundamental
pathogenesis of “diarrhea” and “intestinal dysentery”. It coincides with the damage of intestinal mucus barrier leading to UC in
modern medicine. Based on this， this paper summarized the mechanism of Chinese herbal compounds or Chinese herbal active
components in regulating intestinal mucus barrier to interfere with UC. It was found that Chinese herbal compounds such as
Huanglian jiedu decoction， Shaoyao decoction and Compound Kusen decoction， as well as Chinese herbal active ingredients such
as volatile oil of Atractylodes lancea， paeoniflorin and papaya
Δ 基金项目 广西自然科学基金项目（No.2020GXNSFAA238009）； triterpenes could promote the synthesis and secretion function
广西中医药大学B类“桂派中医药传承创新团队”项目（No.2021B001）； of goblet cells， and achieve the purpose of “thickening
广西中医药大学自然科学研究项目（No.2021QN18） intestine”， thus relieving UC symptoms.
＊第一作者 硕士研究生。研究方向：脾胃四时调五脏防治疾病的
应用。E-mail：1185884631@qq.com KEYWORDS traditional Chinese medicine； ulcerative colitis；
# 通信作者 副主任医师。研究方向：中医治未病及中西医救治急 mucin 2； goblet cell； intestinal mucus barrier
危重症的应用。E-mail：zhongyi-02@163.com

中国药房 2023年第34卷第21期 China Pharmacy 2023 Vol. 34 No. 21 · 2671 ·